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公开(公告)号：WO2019214681A1
公开(公告)日：2019-11-14
申请号：PCT/CN2019/086201
申请日：2019-05-09
发明人： JANG, Ming-Kuei , TEMPEST, Paul
IPC分类号： C07D498/04 , A61K51/04 , C09K19/34 , A61P25/28
摘要： Described herein are compounds of formula (I), and pharmaceutically acceptable salts, solvates, hydrates, isotopically labeled derivatives and radiolabeled derivative thereof, and pharmaceutical compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for detecting and imaging Tau aggregates in the brain for detection of Alzheimer's disease (AD) in a subject.
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公开(公告)号：WO2021024209A1
公开(公告)日：2021-02-11
申请号：PCT/IB2020/057415
申请日：2020-08-05
发明人： JANG, Ming-Kuei , TAI, Chin-Yin
IPC分类号： C07K16/18 , C07K14/47 , A61P25/28 , A61K39/00 , A61K2039/505 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6843 , C07K14/4711 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92 , G01N33/6896
摘要： The present disclosure relates to antibodies that bind selectively to pathological Tau, including compositions and methods relating to such antibodies, such as for treating tauopathies, neurodegenerative diseases associated with pathological aggregation of Tau.
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公开(公告)号：WO2021097243A1
公开(公告)日：2021-05-20
申请号：PCT/US2020/060459
申请日：2020-11-13
发明人： JANG, Ming-Kuei , LIN, Yih-Shyan
IPC分类号： A61K47/55 , C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04 , A61P25/28
摘要： Disclosed herein are novel compounds for degrading Tau protein aggregates, pharmaceutical acceptable salts, enantiomers, non-enantiomers, tautomers, racemates, solvates, metabolic precursors, or prodrugs thereof. Also disclosed herein are uses of the compounds, pharmaceutical acceptable salts, enantiomers, non-enantiomers, tautomers, racemates, solvates, metabolic precursors, or prodrugs thereof in manufacture a medicament for treating a tauopathy, as well as method for aiding in the treatment of a tauopathy or treating a tauopathy in a subject.
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