公开(公告)号：WO2004074266A1

公开(公告)日：2004-09-02

申请号：PCT/EP2004/050084

申请日：2004-02-05

Applicant: JANSSEN PHARMACEUTICA N.V. ,  ARTS, Theodora, Joanna, Francisca ,  JANSSEN, Graziella, Maria, Constantina ,  JANSSEN, Herwig, Josephus, Margareta ,  JANSSEN, Jasmine, Josée, Werner ,  JANSSEN, Paul, Peter, Maria ,  JANSSEN, Maroussia, Godelieve, Frank ,  LEWI, Paulus, Joannes ,  DE JONGE, Marc, René ,  KOYMANS, Lucien, Maria, Henricus ,  VINKERS, Hendrik, Maarten ,  DAEYAERT, Frederik, Frans, Desiré ,  HEERES, Jan ,  LEENDERS, Ruben, Gerardus, George ,  HOORNAERT, Georges, Joseph, Cornelius ,  KILONDA, Amuri ,  LUDOVICI, Donald, William

Inventor： LEWI, Paulus, Joannes ,  DE JONGE, Marc, René ,  KOYMANS, Lucien, Maria, Henricus ,  VINKERS, Hendrik, Maarten ,  DAEYAERT, Frederik, Frans, Desiré ,  HEERES, Jan ,  LEENDERS, Ruben, Gerardus, George ,  HOORNAERT, Georges, Joseph, Cornelius ,  KILONDA, Amuri ,  LUDOVICI, Donald, William

IPC: C07D253/06

CPC classification number: A61K31/53 ,  C07D253/07 ,  C07D253/075

Abstract: The present invention relates to HIV replication inhibitors of formula (I) as defined in the specification their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.

Abstract translation: 本发明涉及如本说明书中定义的式（I）的HIV复制抑制剂，其用作药物，其制备方法和包含它们的药物组合物。

公开(公告)号：WO2004069812A1

公开(公告)日：2004-08-19

申请号：PCT/EP2004/001011

申请日：2004-02-04

Applicant: JANSSEN PHARMACEUTICA N.V. ,  ARTS, Theodora, Joanna, Francisca ,  JANSSEN, Graziella, Maria, Constantina ,  JANSSEN, Herwig, Josephus, Margareta ,  JANSSEN, Jasmine, Josée, Werner ,  JANSSEN, Paul, Peter, Maria ,  JANSSEN, Maroussia, Godelieve, Frank ,  GUILLEMONT, Jérôme, Emile, Georges ,  PASQUIER, Elisabeth, Therese, Jeanne ,  HEERES, Jan ,  LEWI, Paulus, Joannes ,  DE JONGE, Marc, René ,  KOYMANS, Lucien, Maria, Henricus ,  DAEYAERT, Frederik, Frans, Desire ,  VINKERS, Hendrik, Maarten

Inventor： HEERES, Jan ,  LEWI, Paulus, Joannes ,  DE JONGE, Marc, René ,  KOYMANS, Lucien, Maria, Henricus ,  DAEYAERT, Frederik, Frans, Desire ,  VINKERS, Hendrik, Maarten

IPC: C07D239/47

CPC classification number: A61K31/513 ,  C07D239/47 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: This invention concerns the use of a compound for the manufacture of a medicament for the prevention of HIV infection via sexual intercourse and related intimate contact between partners, wherein the compound is a compound of formula (I) a N -oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein the ring containing -a 1 =a 2 -a 3 =a 4 - and -b 1 =b 2 -b 3 =b 4 - represents phenyl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl; and pharmaceutical compositions comprising them.

Abstract translation: 本发明涉及化合物在制备药物中的用途，所述药物通过性交和伴侣之间的相关紧密接触来预防HIV感染，其中所述化合物是式（I）的化合物，N-氧化物，药学上可接受的添加剂 盐，季胺及其立体化学异构形式，其中含-a 1 = a 2 -a 3 = a 4 - 和-b 1 = b 2 -b的环 3 =表示苯基，吡啶基，嘧啶基，吡嗪基，哒嗪基; 和包含它们的药物组合物。

公开(公告)号：WO2004074266A8

公开(公告)日：2004-11-11

申请号：PCT/EP2004050084

申请日：2004-02-05

Applicant: JANSSEN PHARMACEUTICA NV ,  LEWI PAULUS JOANNES ,  ARTS THEODORA JOANNA FRANCISCA ,  JANSSEN GRAZIELLA MARIA CONSTA ,  JANSSEN HERWIG JOSEPHUS MARGAR ,  JANSSEN JASMINE JOSEE WERNER H ,  JANSSEN PAUL PETER MARIA HM ,  JANSSEN MAROUSSIA GODELIEVE FR ,  DE JONGE MARC RENE ,  KOYMANS LUCIEN MARIA HENRICUS ,  VINKERS HENDRIK MAARTEN ,  DAEYAERT FREDERIK FRANS DESIRE ,  HEERES JAN ,  LEENDERS RUBEN GERARDUS GEORGE ,  HOORNAERT GEORGES JOSEPH CORNE ,  KILONDA AMURI ,  LUDOVICI DONALD WILLIAM

Inventor： LEWI PAULUS JOANNES ,  JANSSEN PAUL ADRIAAN JAN DI ,  DE JONGE MARC RENE ,  KOYMANS LUCIEN MARIA HENRICUS ,  VINKERS HENDRIK MAARTEN ,  DAEYAERT FREDERIK FRANS DESIRE ,  HEERES JAN ,  LEENDERS RUBEN GERARDUS GEORGE ,  HOORNAERT GEORGES JOSEPH CORNE ,  KILONDA AMURI ,  LUDOVICI DONALD WILLIAM

IPC: A61K31/53 ,  C07D253/06 ,  C07D253/07 ,  C07D253/075

CPC classification number: A61K31/53 ,  C07D253/07 ,  C07D253/075

Abstract: The present invention relates to HIV replication inhibitors of formula (I) as defined in the specification their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.

Abstract translation: 本发明涉及如说明书中所定义的式（I）的HIV复制抑制剂作为药物的用途，它们的制备方法和包含它们的药物组合物。