公开(公告)号：WO2021255282A1

公开(公告)日：2021-12-23

申请号：PCT/EP2021/066707

申请日：2021-06-18

申请人： UNIVERSITE D'AIX MARSEILLE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE

发明人： GUILLET, Benjamin ,  BOUHLEL, Ahlem ,  MOYON, Anaïs ,  LOUIS, Béatrice, Marie, Florence ,  DIGNAT-GEORGE, Françoise ,  BALASSE, Laure ,  GARRIGUE, Philippe ,  FERNANDEZ, Samantha

IPC分类号： A61K51/08 ,  A61K51/088

摘要： The invention relates to the field of imaging, diagnostic, internal vectorized radiotherapy and nuclear medicine. Inventors herein describe new products for use for labelling, detecting and/or imaging angiogenesis, vasculogenesis or a tissue or organ expressing the APJ receptor; for use for detecting, measuring, diagnosing, staging and/or monitoring angiogenesis, vasculogenesis, an angiogenesis- and/or vasculogenesis-related disease or disorder, and/or a disease or disorder inducing or modulating the expression of a APJ receptor in a tissue or organ; for use for preventing or treating angiogenesis, vasculogenesis, an angiogenesis- and/or vasculogenesis-related disease or disorder, and/or a disease or disorder inducing or modulating the expression of a APJ receptor in a tissue or organ; or for use for evaluating or monitoring the therapeutic effect of an angiogenic or antiangiogenic treatment or of an APJ receptor-targeted treatment. Compositions and kits comprising such products are also herein described as well as uses thereof.

公开(公告)号：WO2020136216A1

公开(公告)日：2020-07-02

申请号：PCT/EP2019/087038

申请日：2019-12-26

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ DE BORDEAUX ,  UNIVERSITÉ D'AIX MARSEILLE ,  ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE ,  COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (CEA) ,  SORBONNE UNIVERSITÉ ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)

发明人： TREGOUET, David-Alexandre ,  MORANGE, Pierre-Emmanuel ,  DELEUZE, Jean-François

IPC分类号： C12Q1/6883

摘要： Coagulation factor V (FV) plays an important and dual role in the regulation of blood coagulation by exhibiting both pro- and anticoagulant functions. In order to detect novel genetic loci participating to the regulation of Factor V (FV) plasma levels, the inventors conducted the first Genome Wide Association Study on this hemostatic phenotype in a sample of 510 individuals and replicated the main findings in an independent samples of 1156 individuals. In addition to genetic variations at the F5 locus, they identified novel associations at the PLXDC2 locus with the PLXDC2 rs927826 polymorphism explaining ~3.7% (p 7.5 10 -15 in the combined discovery and replication samples) of the variability of FV plasma levels. SiRNA experiments in human hepatocellular carcinoma cell line confirmed the role of PLXDC2 in modulating factor F5 gene expression. Accordingly, detecting a genetic variant in the PLXDC2 gene would be suitable for identifying a subject having or at risk of having a coagulation related disorder.

公开(公告)号：WO2020070320A1

公开(公告)日：2020-04-09

申请号：PCT/EP2019/076977

申请日：2019-10-04

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE ,  UNIVERSITÉ D’AIX-MARSEILLE (AMU) ,  UNIVERSITÉ NICE SOPHIA ANTIPOLIS (UNS) ,  ASSISTANCE PUBLIQUE - HÔPITAUX DE MARSEILLE (AP-HM)

发明人： BEL HAJ ALI, Wafa ,  IBRAHIM, El Chérif ,  BELZEAUX, Raoul ,  FILLATRE, Lionel ,  GLAICHENHAUS, Nicolas ,  COURTET, Philippe ,  MARTINUZZI, Emanuela ,  PINTO BARBOSA, Susana Do Carmo

IPC分类号： G01N33/68

摘要： The invention relates to an in vitro or ex vivo method for differentially diagnosing a bipolar disorder and a major depressive disorder in a human patient in a need thereof presenting depressive symptoms, comprising the following steps: providing a biological sample from said patient; determining, from said biological sample, the abundance of at least one of the following cytokines TNF-α, IFN-γ, IL- 6, IL-10, IL-12p40, IL-15, IL-16, IL-17A and IL-27; and diagnosing a bipolar disorder or a major depressive disorder from the determination of the abundance of the at least one of the following cytokines TNF-α, IFN-γ, IL-6, IL-10, IL-12p40, IL-15, IL-16, IL-17A and IL-27.

公开(公告)号：WO2019207236A3

公开(公告)日：2019-10-31

申请号：PCT/FR2019/050894

申请日：2019-04-16

申请人： UNIVERSITÉ D'AIX MARSEILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE CENTRALE DE MARSEILLE ,  ASSISTANCE PUBLIQUE - HÔPITAUX DE MARSEILLE ,  MULTIWAVE TECHNOLOGIES AG

发明人： ENOCH, Stefan ,  ABDEDDAIM, Redha ,  GUEDJ, Éric, Émile, David ,  LE ROUZIC, Raphaëlle ,  BENAMARA, Megdouda ,  BULTOT, Marie Coralie ,  KEFEDER, Michael ,  ANTONAKAKIS, Tryfon

IPC分类号： A61N2/00 ,  A61N2/02

摘要： Ce dispositif d'émission magnétique (100) comporte une antenne (102) et en outre des moyens (106) conçus pour sélectionner une parmi une pluralité de portions prédéfinies de l'antenne (102) et pour connecter la portion sélectionnée à un dispositif de génération de courant (104) afin, d'une part, de faire passer le courant dans la portion sélectionnée de l'antenne (102) pour rayonner un champ magnétique et, d'autre part, d'empêcher le courant de passer hors de la portion sélectionnée de l'antenne (102).

公开(公告)号：WO2019145506A1

公开(公告)日：2019-08-01

申请号：PCT/EP2019/051903

申请日：2019-01-25

申请人： UNIVERSITE D'AIX-MARSEILLE (AMU) ,  ASSISTANCE PUBLIQUE - HÔPITAUX DE MARSEILLE (AP-HM) ,  INSTITUT FRANÇAIS DES SCIENCES ET TECHNOLOGIES DES TRANSPORTS DE L'AMÉNAGEMENT ET DES RÉSEAUX ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： IBOUANGA-KIPOUTOU, Harold, Noble ,  BOUSSEN, Salah ,  M' SIRDI, Kouider, Nacer ,  ARNOUX, Pierre-Jean ,  BRUDER, Nicolas ,  BEHR, Michel

IPC分类号： A61B5/00 ,  A61B5/0205 ,  A61B5/11 ,  G16H40/63 ,  G16H50/20 ,  A61M16/00 ,  A61M16/01

CPC分类号： A61B5/4821 ,  A61B5/0205 ,  A61B5/1118 ,  A61B5/7275 ,  A61M16/01 ,  A61M2016/003 ,  A61M2205/502 ,  A61M2230/005 ,  A61M2230/06 ,  A61M2230/10 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/42 ,  G16H40/63 ,  G16H50/20 ,  G16H50/30

摘要： The invention relates to a method for automatic and continuous measurement of a sedation state of a patient in an intensive care unit. The method according to the invention comprises the following steps: providing signals representative of the condition of the patient, said signals comprising cardio-circulatory signals, signals representative of the respiratory activity and signals representative of the motor activity of the patient; and determining a global index representative of the sedation state of the patient.

公开(公告)号：WO2019068842A1

公开(公告)日：2019-04-11

申请号：PCT/EP2018/077073

申请日：2018-10-05

申请人： UNIVERSITE D'AIX-MARSEILLE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE

发明人： BLOT-CHABAUD, Marcel ,  GUILLET, Benjamin ,  NOLLET, Marie ,  STALIN, Jimmy ,  BARDIN, Nathalie ,  DIGNAT-GEORGE, Françoise

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  A61K51/10

CPC分类号： C07K16/3092 ,  A61K51/1045 ,  A61K51/1093 ,  A61K2039/505 ,  A61P35/00 ,  C07K2317/73 ,  C07K2317/77 ,  G01N33/57419 ,  G01N33/5743 ,  G01N33/57438 ,  G01N2333/70596

摘要： The present invention relates to the field of diagnostic and treatment of cancer, particularly melanoma, pancreatic cancer, kidney cancer and colon cancer. In particular, the invention relates to an antibody directed specifically to CD146-positive tumors and its applications, particularly for use as a medicament for the prevention and/or treatment of cancer, for use in a method of diagnostic or prognostic of a cancer, or for use as a radiotracer when labelled with a radioactive element.

公开(公告)号：WO2019063580A1

公开(公告)日：2019-04-04

申请号：PCT/EP2018/076046

申请日：2018-09-26

申请人： UNIVERSITE D'AIX-MARSEILLE ,  ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

发明人： BLOT-CHABAUD, Marcel ,  NOLLET, Marie ,  BACHELIER, Richard ,  BARDIN, Nathalie ,  DIGNAT-GEORGE, Françoise

IPC分类号： C07K14/705

CPC分类号： C07K14/70503

摘要： The present invention relates to compositions and methods for modulating angiogenesis in vivo , ex vivo or in vitro . More particularly, the invention relates to new soluble CD146 proteins usable in the context of human therapy, as well as to corresponding antibodies. The invention also relates to compositions comprising such compounds, particularly pharmaceutical or diagnostic compositions, including kits and the like, as well as methods of therapy or diagnosis using said compounds, compositions and cells.

公开(公告)号：WO2009004189A2

公开(公告)日：2009-01-08

申请号：PCT/FR2008/000767

申请日：2008-06-06

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  ASSISTANCE PUBLIQUE - HÔPITAUX DE MARSEILLE ,  UNIVERSITE DE LA MEDITERRANEE ,  UNIVERSITE DE CAEN BASSE-NORMANDIE ,  ANGLES CANO, Eduardo ,  LACROIX, Romaric ,  MALATERRE, Florence ,  DIGNAT-GEORGE, Françoise

发明人： ANGLES CANO, Eduardo ,  LACROIX, Romaric ,  MALATERRE, Florence ,  DIGNAT-GEORGE, Françoise

IPC分类号： G01N33/569

CPC分类号： C12Q1/56 ,  G01N33/86 ,  G01N33/92

摘要： L'invention a pour objet une méthode de mesure de l'activité plasmine des microparticules, particulièrement les microparticules circulantes, d'un échantillon de fluide biologique, particulièrement un fluide biologique en situation d'écoulement, ladite méthode pouvant servir comme méthode de diagnostic ou comme méthode de suivi d'un traitement.

摘要翻译： 本发明涉及一种用于在流动情况下测量生物流体，特别是生物流体样品中微粒特别是循环微粒的等离子体活性的方法，其中所述方法可用作诊断方法或方法 接受治疗。

公开(公告)号：WO2021233966A1

公开(公告)日：2021-11-25

申请号：PCT/EP2021/063235

申请日：2021-05-19

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITÉ D'AIX MARSEILLE ,  ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE ,  ECOLE NORMALE SUPÉRIEURE DE LYON ,  INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) ,  UNIVERSITÉ CLAUDE BERNARD - LYON 1

发明人： VIDALAIN, Pierre-Olivier ,  NOUGAIREDE, Antoine ,  TOURET, Franck ,  ANDRE, Patrice ,  LOTTEAU, Vincent ,  DE LAMBALLERIE, Xavier Nicolas ,  JANIN, Yves Louis

IPC分类号： A61K31/4196 ,  A61K31/427 ,  A61K31/4706 ,  A61K31/513 ,  A61K31/706 ,  A61K45/06 ,  A61P31/14 ,  A61K31/685 ,  A61K38/21

摘要： Coronaviridae is a family of enveloped, positive-sense, single-stranded RNA viruses. The emergence of a new betacoronavirus SARS-CoV-2 has led to a major health-related crisis associated with a significant mortality in intensive care units, due to the pulmonary complications of COVID-19. The inventors showed that BAY-2402234 is suitable for inhibiting replication of coronavirus and thus would be suitable for the treatment of infections mediated by said type of virus.

公开(公告)号：WO2020201362A2

公开(公告)日：2020-10-08

申请号：PCT/EP2020/059272

申请日：2020-04-01

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  SORBONNE UNIVERSITÉ, ,  UNIVERSITÉ DE PARIS ,  UNIVERSITÉ D'AIX MARSEILLE ,  ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE ,  UNIVERSITÉ LIBRE DE BRUXELLES ,  TRUSTEES OF BOSTON UNIVERSITY

发明人： GALON, Jérôme ,  MASCAUX, Céline ,  ANGELOVA, Mihaela ,  SCULIER, Jean-Paul ,  BALE, Jennifer ,  HIJAZI, Kahkeshan ,  SPIRA, Avurm

IPC分类号： C12Q1/6886

摘要： As advanced cancer has poor prognosis, its detection and treatment at the earliest stages is critical to increase cancer survival rate. Therefore, elucidating the determinants of the intra- lesion immune reaction during cancer's developments is critical for moving into precision medicine and immunotherapy-based cancer prevention. Adaptive immune response within tumors was shown to be the strongest at the earliest stage of carcinoma. Thus, the inventors hypothesized that the immune microenvironment and adaptive immunity were first established at early stage of lung carcinogenesis. Here they identified changes in the tumor molecular profile and its microenvironment during the successive steps of lung squamous carcinogenesis, using gene expression profiling and multispectral imaging. A unique and invaluable dataset of (9) morphological stages of development was analyzed, including (122) well-annotated biopsies from (77) patients. In particular, the inventors show that immune activation and immune escape occur before tumor invasion, and that immunosuppressive cytokines and checkpoint receptors immune escape mechanisms are concomitant with anti-tumor immunity in high-grade dysplasia. Thus, the present invention relates to methods of predicting and preventing cancer in subjects having premalignant lesions.