公开(公告)号：WO2019149911A1

公开(公告)日：2019-08-08

申请号：PCT/EP2019/052549

申请日：2019-02-01

申请人： UNIVERSITÉ DE RENNES 1 ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

发明人： HASSAN, Mahmoud ,  WENDLING, Fabrice ,  KABBARA, Aya

IPC分类号： G16H50/20 ,  G16H20/40 ,  A61B5/00

CPC分类号： G16H20/40 ,  A61B5/4094 ,  G16H50/20 ,  G16H50/30

摘要： The invention relates to a method of constructing a value representative of an interaction between a plurality of brain networks, the method being implemented by an electronic device, said electronic device comprising a processor and a memory. According to the invention, the method comprises: obtaining (10), in the form of connectivity matrices, dynamic functional networks, which are representative of electrical signals measured for a predetermined number of points of interest, called nodes, within a cerebral cortex during a given time period; grouping (20) of the nodes, as a function of topological properties of said networks, within groups of nodes called modules; calculating (30) the index representing local epileptogenic network as a function of local functional connectivity characteristics of said nodes, modules and networks.

公开(公告)号：WO2019139975A1

公开(公告)日：2019-07-18

申请号：PCT/US2019/012883

申请日：2019-01-09

申请人： HEALTHCARE INTERACTIVE, INC. ,  CHA, Henry, H.

发明人： CHA, Henry, H.

IPC分类号： G06Q40/08

CPC分类号： G16H50/30 ,  G06F17/2785 ,  G06F17/289 ,  G06Q40/08 ,  G06Q50/22 ,  G16H10/60 ,  G16H20/90 ,  G16H50/20

摘要： A method for improving the speed of determining a health risk profile associated with a patient may include the step of retrieving patient medical information about the patient, wherein the patient medical information is an uncoded natural language expression in a first language. The method may also include comparing the patient medical information with records in a first database. If the patient medical information matches the preselected medical information, the method includes performing a first data conversion procedure. If the patient medical information fails to match any record in the first database, the method includes performing a second data conversion procedure, wherein the first data conversion procedure is performed faster than the second data conversion procedure.

公开(公告)号：WO2019139884A1

公开(公告)日：2019-07-18

申请号：PCT/US2019/012656

申请日：2019-01-08

申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.

发明人： DENO, Don Curtis ,  OLSON, Eric S. ,  MORGAN, Dennis J. ,  SCHWEITZER, Jeffrey A. ,  VOTH, Eric J.

IPC分类号： G16H50/20

CPC分类号： A61B5/044 ,  A61B5/04011 ,  A61B5/0408 ,  A61B5/0488 ,  A61B5/7246 ,  G16H50/20

摘要： Electrophysiological signals from a graphical representation of an electrophysiology map including a plurality of electrophysiology data points can be sorted by receiving user inputs specifying a number of virtual electrodes for a virtual catheter and defining a pathway of the virtual catheter. A corresponding number of virtual electrodes can be defined on the pathway of the virtual catheter, and one or more electrophysiology data points relevant to electrical activity at the virtual electrodes can be identified, allowing output of a graphical representation of electrophysiological signals corresponding to the identified electrophysiology data points. Relevant electrophysiololgy data points can be identified by applying one or more relevance criterion, such as a distance criterion, a bipole orientation criterion, a time criterion, and/or a morphology criterion.

公开(公告)号：WO2019137576A1

公开(公告)日：2019-07-18

申请号：PCT/DE2019/000008

申请日：2019-01-14

申请人： BARTEN-RENON, Michael

发明人： BARTEN-RENON, Michael

IPC分类号： G16H10/20 ,  G16H40/63 ,  G16H50/30 ,  G16H50/20 ,  G16H70/60

CPC分类号： G16H10/20 ,  G16H40/63 ,  G16H50/20 ,  G16H50/30 ,  G16H70/60

摘要： Automatisierte Datenermittlung zur interaktiven Diagnose eines Patienten mit psychischen Störungen durch Einsatz eines Computers mit einer Datenbank und einer Spracherkennung, wobei der Computer über einen Lautsprecher und ein Mikrofon und /oder einem Bildschirm mit einer Eingabemöglichkeit Fragen verbal an den Patienten aussendet, wobei der Computer anhand der vom Patienten verbal abgegebenen Antworten mit in einer Datenbank abgelegten Profilen einen Abgleich durchführt, um eine psychische Erkrankung zu diagnostizieren, wobei der Computer bei Kongruenz der Antworten zu einem in der Datenbank hinterlegten spezifischen Profil weitere Fragen stellt und / oder eine Therapieempfehlung aussendet.

公开(公告)号：WO2019136110A1

公开(公告)日：2019-07-11

申请号：PCT/US2019/012116

申请日：2019-01-03

申请人： CAREBAND INCORPORATED

发明人： SOBOL, Adam G. ,  KREIDLER, Joseph T. ,  DONLIN, Brian A. ,  LEDWITH, Jon G. ,  MCVEY, Patrick J. ,  MOORE, Ross D. ,  NANNI, Peter ,  FORSYTH, Dwayne D. ,  SHELDON, Paul ,  SOBOL, Todd ,  REED, John D.

IPC分类号： G08C17/02

CPC分类号： A61B5/02055 ,  A61B5/0002 ,  A61B5/0022 ,  A61B5/01 ,  A61B5/021 ,  A61B5/02438 ,  A61B5/029 ,  A61B5/0402 ,  A61B5/0816 ,  A61B5/1112 ,  A61B5/1113 ,  A61B5/1118 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/14551 ,  A61B5/4088 ,  A61B5/6803 ,  A61B5/6804 ,  A61B5/681 ,  A61B5/6822 ,  A61B5/6829 ,  A61B5/686 ,  A61B5/7267 ,  A61B5/7275 ,  A61B5/7435 ,  A61B2560/0214 ,  A61B2560/0242 ,  A61B2560/0252 ,  A61B2560/0257 ,  A61B2562/0219 ,  A61B2562/029 ,  A61B2562/06 ,  G06N20/00 ,  G08B21/0211 ,  G08B21/0269 ,  G08B21/0272 ,  G08B21/0288 ,  G08C17/02 ,  G16H40/67 ,  G16H50/20 ,  H04B1/385

摘要： A wearable electronic device, a system and methods of monitoring with a wearable electronic device. The device includes a hybrid wireless communication module with wireless communication sub-modules to selectively acquire location data from both indoor and outdoor sources, as well as a wireless communication sub-module to selectively transmit an LPWAN signal to provide location information based on the acquired data. The device may also include one or more sensors to collect one or more of environmental data, activity data and physiological data. The device may transmit some or all of its acquired data to a larger system, including a cloud-based server to, in addition to providing location-based data, be used as a part of a predictive health care protocol to correlate changes in acquired data to salient indicators of the health of a wearer of the device. In one form, the predictive health care protocol uses a machine learning model.

公开(公告)号：WO2019129857A1

公开(公告)日：2019-07-04

申请号：PCT/EP2018/097088

申请日：2018-12-28

申请人： HILLO AI

发明人： BIDET, Stéphane ,  CALECA, Nicolas ,  REHN, Mickael ,  DE LA BROSSE, Lucas ,  CAMALON, Thibault

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/11 ,  G16H50/50 ,  A61B5/16

CPC分类号： A61B5/14532 ,  A61B5/1118 ,  A61B5/165 ,  A61B5/7275 ,  A61B5/7278 ,  G16H50/20 ,  G16H50/50

摘要： Method for predicting glycemia of a patient including the steps of: Retrieving a data set (2) of dated glycemia measured up to the time t on the patient; Retrieving a quantity of insulin (5) injected in the patient; Retrieving a quantity of glucose (6) ingested by the patient; Generating, by a pharmacokinetic pre-processing device (20), an insulin blood concentration signal (21) and a carbs rate of appearance signal (22), from the glycemia data set (2), the quantities of injected insulin (5) and ingested glucose (6), Predicting by at least one Neural Network at least one glycemia (41) at prediction time t+Δΐ from the glycemia data (2) and from the signals generated (21) (22), the neural network being a Recurrent Neural Network able to keep in memory at each iteration information from any previous iteration.

公开(公告)号：WO2019126721A1

公开(公告)日：2019-06-27

申请号：PCT/US2018/067240

申请日：2018-12-21

申请人： ABIOMED, INC.

发明人： LIU, Chen ,  KATERJI, Admad El ,  CORBETT, Scott

IPC分类号： G16H20/40 ,  A61M5/14 ,  G16H20/17 ,  G16H50/00 ,  A61M1/10

CPC分类号： A61M1/1086 ,  A61B5/00 ,  A61M1/101 ,  A61M1/1031 ,  A61M1/122 ,  A61M1/125 ,  A61M2205/04 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/3365 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/584 ,  A61M2230/06 ,  A61M2230/20 ,  A61M2230/208 ,  A61M2230/30 ,  A61M2230/43 ,  G06N5/045 ,  G06N20/00 ,  G16H20/17 ,  G16H20/40 ,  G16H50/00 ,  G16H50/20

摘要： Systems and methods are provided herein for treating a patient in cardiogenic shock. An intravascular heart pump system is inserted into vasculature of the patient. The heart pump system has a cannula, pump outlet, pump inlet, and rotor. The heart pump system is positioned within the patient such that the cannula extends across the patient's aortic valve, the pump inlet is located within the patient's left ventricle, and the pump outlet is located within the patient's aorta. Data related to time-varying parameters of the heart pump system is acquired from the heart pump system. A plurality of features are extracted from the data. A probability of survival of the patient is determined based on the plurality of features and using a prediction model. The heart pump system is operated to treat the patient.

公开(公告)号：WO2019120658A1

公开(公告)日：2019-06-27

申请号：PCT/EP2018/076513

申请日：2018-09-28

申请人： KONINKLIJKE PHILIPS N.V.

发明人： VAN DE STOLPE, Anja ,  HOLTZER, Laurentius, Henricus, Franciscus, Maria

IPC分类号： G16B5/20 ,  C12Q1/6886

CPC分类号： G16B25/00 ,  C12Q1/6886 ,  C12Q2600/158 ,  G06N5/02 ,  G06N7/005 ,  G06N20/00 ,  G16B5/00 ,  G16B20/00 ,  G16C20/70 ,  G16H20/10 ,  G16H50/20 ,  G16H50/30 ,  G16H50/50

摘要： The present invention relates to a computer-implemented method for inferring activity of a MAPK-AP-1 cellular signaling pathway in a subject based on expression levels of three or more target genes of the MAPK-AP-1 cellular signaling pathway measured in a sample of the subject. The present invention further relates to an apparatus, to a non-transitory storage medium, and to a computer program for inferring activity of a MAPK- AP-1 cellular signaling pathway in a subject. The present invention further relates to a kit for measuring expression levels of three or more target genes of the MAPK-AP-1 cellular signaling pathway in a sample of a subject, to a kit for inferring activity of a MAPK-AP-1 cellular signaling pathway in a subject, and to the use of such kits in performing the method.

公开(公告)号：WO2019118047A1

公开(公告)日：2019-06-20

申请号：PCT/US2018/053003

申请日：2018-09-27

申请人： MEDTRONIC, INC.

发明人： MILBRANDT, Jennifer L. ,  STREETER, Lindsay M. ,  BRAVINDER, Jennifer K. ,  CHISMAR, Jeffrey D. ,  NASLUND, Jeffrey D.

IPC分类号： G16H10/60 ,  G16H50/20 ,  G16H15/00 ,  G16H20/10

CPC分类号： G16H10/60 ,  G16H15/00 ,  G16H20/10 ,  G16H40/20 ,  G16H50/20 ,  G16H70/20 ,  G16H80/00

摘要： A computing system receives an indication of user input indicating whether a clinician accepts use of a set of default values for variables in a management protocol (MP) template in an MP for a particular patient. The computing system generates a description of the MP for the particular patient that specifies the values of the variables in the MP for the particular patient. Additionally, the computing system provides the description of the MP for the particular patient to the particular patient. Subsequently, the computing system receives data indicating health outcomes of the particular patient. The computing system generates, based on the health outcomes of patients, comparison data comparing health outcomes of patients whose MPs specify a first set of values of the variables versus health outcomes of patients whose MPs specify a second, different set of values of the variables.

公开(公告)号：WO2019117563A1

公开(公告)日：2019-06-20

申请号：PCT/KR2018/015610

申请日：2018-12-10

申请人： 삼성전자 주식회사

发明人： 쿠르니아완아구스 ,  쿠스나디조세핀 ,  아드난리스만

IPC分类号： G16H10/20 ,  G16H50/20 ,  G16H50/30 ,  G16H40/67 ,  G16H80/00

CPC分类号： G16H10/20 ,  G16H40/67 ,  G16H50/20 ,  G16H50/30 ,  G16H80/00

摘要： 본 발명은 일반적으로 대화형 원격 의료(interactive telehealth) 진단을 제공하는 통합 예측 분석 시스템 및 방법에 관한 것으로서, 건강 데이터의 분류 및 인식, 건강에 대한 권장 사항 분석 및 건강 데이터에 대한 인지 원격 의료 시각화(cognitive telehealth visualization for health data)로 구성된다. 대화형 원격 의료를 위한 통합 예측 분석 장치가 제공된다. 통합 예측 분석 장치는, 센서 디바이스들로부터 센서 데이터를 수신하고, 센서 데이터를 처리하여 건강 데이터를 생성하는, 허브 및 건강 데이터를 처리하고 시각화하는, 건강 관리 분석 유닛을 포함할 수 있다.