公开(公告)号：WO2016085997A2

公开(公告)日：2016-06-02

申请号：PCT/US2015062455

申请日：2015-11-24

Applicant: AYTU BIOSCIENCE INC

Inventor： BAR-OR RAPHAEL ,  BAR-OR DAVID ,  RAEL LEONARD T ,  BJUGSTAD KIMBERLY B

IPC: C12Q1/26

CPC classification number: G01N33/48707 ,  A61B10/0045 ,  A61B10/0058 ,  A61B2010/0074 ,  G01N27/4168 ,  G01N33/487 ,  G06F19/3431 ,  G16H50/30

Abstract: Methods and systems for measuring and using the oxidation-reduction potential (ORP) of a biological sample are provided. The system generally includes a test strip and a readout device for determining the ORP. The measured ORP is then used to determine characteristics relating to the fertility of the sample or the subject from which the sample was derived. Some characteristics that can be determined include the quality of a sperm sample, an oocyte or a fertilized egg. The measured ORP value can also be used to determine the specific characteristics of a spermatozoa sample, such as the morphology of the spermatozoa, the motility of the spermatozoa, the number of cells in the sample and the concentration of the cells in the sample. Knowledge of such characteristics and fertility potential can be used to identify individuals that might benefit from specific fertility treatments.

Abstract translation: 提供了用于测量和使用生物样品的氧化还原电位（ORP）的方法和系统。 该系统通常包括测试条和用于确定ORP的读出设备。 然后使用测量的ORP来确定与样品或衍生样品的受试者的生育力有关的特征。 一些可以确定的特征包括精子样本，卵母细胞或受精卵的质量。 测量的ORP值也可用于确定精子样本的特定特征，例如精子的形态，精子的运动性，样本中细胞的数量和样本中细胞的浓度。 这些特征和生育潜力的知识可以用来识别可能受益于特定生育治疗的个体。

公开(公告)号：WO2018175885A1

公开(公告)日：2018-09-27

申请号：PCT/US2018/024023

申请日：2018-03-23

Applicant: AYTU BIOSCIENCE, INC.

Inventor： BAR-OR, David ,  BAR-OR, Raphael ,  DORSEY, Charles

IPC: G01N27/26 ,  G01N27/416 ,  G01N33/50 ,  G01N33/68 ,  G01N33/92

CPC classification number: G01N27/4168 ,  G01N33/50 ,  G01N33/68 ,  G01N33/92

Abstract: Methods and systems for measuring and using the oxidation-reduction potential (ORP) of a biological sample are provided. The ORP measurements are used to determine the quality of an oocyte or a fertilized egg. Knowledge of the quality of a fertilized egg allows the selection of eggs most likely to result in a successful pregnancy. Such knowledge can also be used to determine the optimal time for transferring a fertilized egg into the uterus, increasing the likelihood of a successful pregnancy.

公开(公告)号：WO2016085997A3

公开(公告)日：2016-06-02

申请号：PCT/US2015/062455

申请日：2015-11-24

Applicant: AYTU BIOSCIENCE, INC.

Inventor： BAR-OR, Raphael ,  BAR-OR, David ,  RAEL, Leonard, T. ,  BJUGSTAD, Kimberly, B.

IPC: A61D19/00 ,  G01N33/92 ,  G01N27/26

Abstract: Methods and systems for measuring and using the oxidation-reduction potential (ORP) of a biological sample are provided. The system generally includes a test strip and a readout device for determining the ORP. The measured ORP is then used to determine characteristics relating to the fertility of the sample or the subject from which the sample was derived. Some characteristics that can be determined include the quality of a sperm sample, an oocyte or a fertilized egg. The measured ORP value can also be used to determine the specific characteristics of a spermatozoa sample, such as the morphology of the spermatozoa, the motility of the spermatozoa, the number of cells in the sample and the concentration of the cells in the sample. Knowledge of such characteristics and fertility potential can be used to identify individuals that might benefit from specific fertility treatments.

公开(公告)号：WO2019089770A1

公开(公告)日：2019-05-09

申请号：PCT/US2018/058479

申请日：2018-10-31

Applicant: AYTU BIOSCIENCE, INC.

Inventor： AGARWAL, Ashok ,  SHARMA, Rakesh ,  GUPTA, Sajal ,  DORSEY, Charles Clifford Joseph ,  ELBARDISI, Haitham Tharwat Mohamed

IPC: G01N27/416 ,  A61B10/00 ,  G01N33/487

CPC classification number: G01N27/4168 ,  A61B10/0058 ,  G01N33/48707 ,  G01N2800/367

Abstract: Methods for treatment of infertility and for determining appropriate treatment of infertility in varicocele patients involving the use of the oxidation-reduction potential (ORP) status of semen samples are provided. In addition, methods for determining the effectiveness of a varicocelectomy procedure on infertile male subjects is provided.

公开(公告)号：WO2016172344A1

公开(公告)日：2016-10-27

申请号：PCT/US2016/028653

申请日：2016-04-21

Applicant: AYTU BIOSCIENCE, INC.

Inventor： BJUGSTAD, Kim ,  BAR-OR, Raphael ,  BAR-OR, David

IPC: G01N27/26 ,  G01N27/30 ,  G01N33/50

CPC classification number: G01N33/48707

Abstract: Methods and systems for measuring and using the oxidation-reduction potential (ORP) of a biological sample are provided. Also provided are methods of characterizing an individual who has suffered a stroke by measuring the ORP of a biological sample. The disclosed methods can be used to characterize the individual with regard to their likelihood of survival, severity of the stroke and their estimated length of stay in a medical facility.

Abstract translation: 提供了用于测量和使用生物样品的氧化还原电位（ORP）的方法和系统。 还提供了通过测量生物样品的ORP来表征患有中风的个体的方法。 所公开的方法可以用于表征个体在其生存的可能性，中风的严重程度及其在医疗设施中的滞留时间。

公开(公告)号：WO2019152854A1

公开(公告)日：2019-08-08

申请号：PCT/US2019/016373

申请日：2019-02-01

Applicant: AYTU BIOSCIENCE, INC. ,  ACERUS BIOPHARMA INC.

Inventor： WESTFIELD, Gerwin ,  ZWIERKO, Margaux ,  RAMASAMY, Ranjith ,  BRYSON, Nathan

IPC: A61K31/568 ,  A61M5/20 ,  A61M5/30

Abstract: Methods and systems for preventing or reducing side effects of testosterone replacement therapy (TRT) by administering a testosterone formulation multiple times per day are disclosed. The methods of the present invention enable men who cannot tolerate previous TRT regimens, e.g. because they wish to attempt to conceive or are at risk of developing cardiovascular side effects, to receive TRT treatment.