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公开(公告)号：WO2012054530A3
公开(公告)日：2013-10-31
申请号：PCT/US2011056773
申请日：2011-10-18
申请人： ELCELYX THERAPEUTICS INC , BARON ALAIN D , BROWN MARTIN R , JONES CHRISTOPHER R G , BEELEY NIGEL R A
IPC分类号： C12Q1/02
CPC分类号： C07C309/46 , A61K9/2054 , A61K9/2086 , A61K9/2846 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/197 , A61K31/198 , A61K31/201 , A61K31/216 , A61K31/343 , A61K31/36 , A61K31/405 , A61K31/4709 , A61K31/7016 , A61K31/704 , A61K38/05 , C07C69/28 , C07C69/533 , C07C233/75 , C07C235/64 , C07C237/08 , C07D209/20 , C07D307/85 , C07D317/68
摘要： Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.
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公开(公告)号：WO2012054526A8
公开(公告)日：2012-04-26
申请号：PCT/US2011/056769
申请日：2011-10-18
申请人： ELCELYX THERAPEUTICS, INC. , BARON, Alain, D. , BROWN, Martin, R. , JONES, Christopher, R.G. , BEELEY, Nigel, R.A.
摘要： Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.
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公开(公告)号：WO2006086769A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/005020
申请日：2006-02-10
申请人： AMYLIN PHARMACEUTICALS, INC. , LEVY, Odile Esther , HANLEY, Michael R. , JODKA, Carolyn M. , LEWIS, Diana Y. , SOARES, Christopher J. , GHOSH, Soumitra S. , D'SOUZA, Lawrence J. , PARKES, David G. , MACK, Christine M. , SRIVASTAVA, Ved , JANSSEN, Samuel , BARON, Alain D. , YOUNG, Andrew A. , PITTNER, Richard A. , ERICKSON, Mary
发明人： LEVY, Odile Esther , HANLEY, Michael R. , JODKA, Carolyn M. , LEWIS, Diana Y. , SOARES, Christopher J. , GHOSH, Soumitra S. , D'SOUZA, Lawrence J. , PARKES, David G. , MACK, Christine M. , SRIVASTAVA, Ved , JANSSEN, Samuel , BARON, Alain D. , YOUNG, Andrew A. , PITTNER, Richard A. , ERICKSON, Mary
IPC分类号： C07K14/575
CPC分类号： C07K14/575 , C07K14/605 , C07K2319/00
摘要： The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译： 本发明一般涉及具有可选特性的新型GIP类似物和GIP杂合多肽，其可用作治疗和预防代谢性疾病和病症的药剂，例如可通过控制血浆葡萄糖 水平，胰岛素水平和/或胰岛素分泌，正性肌力作用，分解代谢作用的减少，胃排空减慢。 此类病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，危重病护理，胰岛素抵抗，肥胖和任何种类的糖尿病，包括1型，2型和妊娠糖尿病。 / p>
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公开(公告)号：WO2005037291A1
公开(公告)日：2005-04-28
申请号：PCT/US2004/034264
申请日：2004-10-18
发明人： BARON, Alain, D. , CHEN, Kim, Seng
IPC分类号： A61K31/695
CPC分类号： A61K31/695
摘要： The present invention generally relates to the therapeutic and prophylactic methods and compositions for improving vascular health. In one embodiment, the methods of the invention include administering a therapeutically or prophylactically effective amount of at least one silyl phenol compound according to the present invention to a subject in need of treatment, wherein the amount is therapeutically or prophylactically effective in the treatment or prevention of major adverse cardiac events, vascular access dysfunction, or male erectile dysfunction.
摘要翻译： 本发明一般涉及用于改善血管健康的治疗和预防方法和组合物。 在一个实施方案中，本发明的方法包括向需要治疗的受试者施用治疗或预防有效量的至少一种本发明的甲硅烷基酚化合物，其中所述量在治疗或预防中是治疗上或预防有效的 主要不良心脏事件，血管通路功能障碍或男性勃起功能障碍。
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公开(公告)号：WO2004056313A3
公开(公告)日：2004-11-25
申请号：PCT/US0340504
申请日：2003-12-17
发明人： HATHAWAY DAVID R , BARON ALAIN D
IPC分类号： A61K38/22 , A61K38/26 , C07K14/575
CPC分类号： A61K38/26 , A61K38/2278
摘要： Compositions of the invention, including compounds that bind to a receptor for a glucagon-like peptide-1, an intecrin, a glucagon-like peptide-1 (GLP-1), an exendin, or an aforementioned compounds, are used in the prevention and treatment of arrhythmias associated with cardiac ischemia, cardiac ischemia-perfusion and/or congestive heart failure. The invention relates to both the method and compositions for such treatment.
摘要翻译： 本发明的组合物包括与胰高血糖素样肽-1，互补蛋白，胰高血糖素样肽-1（GLP-1），毒蜥外泌肽或上述化合物的受体结合的化合物用于预防 和治疗与心脏缺血相关的心律失常，心脏缺血灌注和/或充血性心力衰竭。 本发明涉及用于这种治疗的方法和组合物。
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公开(公告)号：WO2012054528A3
公开(公告)日：2012-08-02
申请号：PCT/US2011056771
申请日：2011-10-18
申请人： ELCELYX THERAPEUTICS INC , BARON ALAIN D , BROWN MARTIN R , JONES CHRISTOPHER R G , BEELEY NIGEL R A
IPC分类号： A01N37/12 , A01N37/44 , A61K31/195
CPC分类号： A61K31/706 , A61K31/164 , A61K31/165 , A61K31/185 , A61K31/194 , A61K31/195 , A61K31/198 , A61K31/20 , A61K31/23 , A61K31/231 , A61K31/255 , A61K31/275 , A61K31/341 , A61K31/415 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4439 , A61K31/4545 , A61K31/5377 , A61K31/661 , A61K31/662 , A61K31/7008 , A61K31/7034 , A61K31/704 , A61K45/06
摘要： Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.
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公开(公告)号：WO2012054528A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056771
申请日：2011-10-18
申请人： ELCELYX THERAPEUTICS, INC. , BARON, Alain, D. , BROWN, Martin, R. , JONES, Christopher, R.G. , BEELEY, Nigel, R.A.
IPC分类号： A61K31/4709 , A61K31/704 , A61K31/7016 , A61K31/198 , A61K31/201 , A61K31/353 , A61K31/155 , A61K31/7032 , A61K31/194 , A61K31/575 , A61P7/12 , A61P3/04 , A61P3/00 , A61P3/10 , A61P19/10 , A61P21/00 , A61P37/00 , A61P1/00 , A61P25/24 , A61P25/22 , A61P25/00 , A61K31/20
CPC分类号： A61K31/706 , A61K31/164 , A61K31/165 , A61K31/185 , A61K31/194 , A61K31/195 , A61K31/198 , A61K31/20 , A61K31/23 , A61K31/231 , A61K31/255 , A61K31/275 , A61K31/341 , A61K31/415 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4439 , A61K31/4545 , A61K31/5377 , A61K31/661 , A61K31/662 , A61K31/7008 , A61K31/7034 , A61K31/704 , A61K45/06
摘要： Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.
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公开(公告)号：WO2005039596A1
公开(公告)日：2005-05-06
申请号：PCT/US2004/034093
申请日：2004-10-18
发明人： BARON, Alain, D. , CHEN, Kim, Seng
IPC分类号： A61K31/695
CPC分类号： A61K31/695 , A61K31/10 , A61K45/06 , A61K2300/00
摘要： The present invention generally relates to the therapeutic and prophylactic methods and compositions for improving vascular health. In one embodiment, the methods of the invention include administering a therapeutically or prophylactically effective amount of at least one compound of the present invention to a subject in need of treatment, wherein the amount is therapeutically or prophylactically effective in the treatment or prevention of major adverse cardiac events, vascular access dysfunction, or male erectile dysfunction.
摘要翻译： 本发明一般涉及用于改善血管健康的治疗和预防方法和组合物。 在一个实施方案中，本发明的方法包括向需要治疗的受试者施用治疗或预防有效量的至少一种本发明化合物，其中所述量在治疗或预防上有效地治疗或预防主要副作用 心脏事件，血管通路功能障碍或男性勃起功能障碍。
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公开(公告)号：WO2004056317A3
公开(公告)日：2004-12-23
申请号：PCT/US0340713
申请日：2003-12-19
申请人： AMYLIN PHARMACEUTICALS INC , BARON ALAIN D , HATHAWAY DAVID R , MISTRY MAHESH , ROMAN RICHARD J
CPC分类号： A61K38/26 , A61K31/7004 , A61K33/00 , A61K38/2278
摘要： Compositions and methods for the prevention and treatment of nephropathy, including hypertensive and diabetic nephropathy, and nephropathy associated with insulin resistance and metabolic syndrome are described. Compositions of the invention include a compound that binds to a receptor for the glucagon like peptide-1, an incretin, a glucagon-like peptide-1 (GLP-1), an exendin, or an analog (including an agonist analog), derivative, or variant of any of them.
摘要翻译： 描述了用于预防和治疗肾病（包括高血压和糖尿病性肾病）和与胰岛素抵抗和代谢综合征相关的肾病的组合物和方法。 本发明的组合物包括结合胰高血糖素样肽-1，肠降血糖素，胰高血糖素样肽-1（GLP-1），毒蜥外泌肽或类似物（包括激动剂类似物）的受体，衍生物 ，或者它们中的任何一个的变体。
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10.发明申请
公开(公告)号：WO2013103384A1
公开(公告)日：2013-07-11
申请号：PCT/US2012/046335
申请日：2012-07-11
IPC分类号： A61K31/155 , A61K31/343 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/341 , A61K31/41 , A61K31/53 , A61P3/00
CPC分类号： A61K31/155 , A61K9/2086 , A61K9/2806 , A61K9/4808 , A61K31/137 , A61K31/341 , A61K31/35 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4196 , A61K31/4453 , A61K31/454 , A61K31/485 , A61K31/53 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
摘要翻译： 本文提供了通过施用包含双胍或相关杂环化合物（例如二甲双胍）的组合来治疗某些病症（包括糖尿病，肥胖症和其它代谢疾病，病症或病症）的方法。 本文还提供双胍类或相关杂环化合物组合物及其制备用于本发明方法的方法。 本文还提供包含二甲双胍及其盐及其使用方法的组合物。
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