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公开(公告)号：WO2023077225A1
公开(公告)日：2023-05-11
申请号：PCT/CA2022/051623
申请日：2022-11-02
申请人： MACH32 INC.
IPC分类号： A61K31/195 , A61M5/20 , A61P7/04 , C07C229/46
摘要： The present disclosure is generally directed to a delivery device for the automatic injection of a dose of a fluid into the target site of a subject. The delivery device generally includes a lower body, an upper body that can be movably disposed over the lower body to activate the delivery device and an injection assembly operable for injecting and delivering a fluid to the target site.
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2.发明申请
公开(公告)号：WO2023037368A1
公开(公告)日：2023-03-16
申请号：PCT/IL2022/050979
申请日：2022-09-08
发明人： BARANES, Danny
IPC分类号： A61K33/10 , A61K9/00 , A61K31/194 , A61K31/195 , A61P17/02
摘要： A method of treating a chronic wound, a non-bleeding wound, an inflammatory pain or a nociceptive pain in a subject in need thereof. The method comprising administering to the subject an effective amount of a composite material comprising a calcium carbonate-containing material, and an associating moiety being associated with the calcium carbonate-containing material.
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公开(公告)号：WO2022261344A8
公开(公告)日：2022-12-15
申请号：PCT/US2022/032862
申请日：2022-06-09
IPC分类号： A61K31/195 , A61K9/00 , A61K31/00 , A61K31/196 , A61K47/10 , A61K47/183 , A61K47/26 , A61K9/0019
摘要： The present invention features methods and compositions for the subcutaneous administration of bumetanide for the treatment of subjects suffering from edema refractory to oral diuretics.
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公开(公告)号：WO2022253819A1
公开(公告)日：2022-12-08
申请号：PCT/EP2022/064731
申请日：2022-05-31
申请人： N.V. NUTRICIA
发明人： GENUNEIT, Jon , SIZIBA, Linda , ROTHENBACHER, Dietrich , BUCHENAUER, Lisa , MANK, Marko , STAHL, Bernd , WIERTSEMA, Selma , VAN SADELHOFF, Joris Henricus Johannes , WITTE, Gerrit , HOGENKAMP, Astrid
IPC分类号： A23L33/00 , A23L33/175 , A61K31/195 , A61P11/06 , A61P11/08 , A61P17/00
摘要： The present invention relates to a method of fortifying human nutrition with free amide containing amino acids, a method of providing infant nutrition to an infant of a lactating woman that suffers from allergy or of a lactating woman that has suffered from allergy, and supplements or fortified infant formulas comprising free L-glutamine and/or free L-asparagine for use in the treatment or prevention of allergy in infants of a lactating woman that suffers from allergy or of a lactating woman that has suffered from allergy.
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公开(公告)号：WO2022250085A1
公开(公告)日：2022-12-01
申请号：PCT/JP2022/021408
申请日：2022-05-25
申请人： 花王株式会社
IPC分类号： A61K45/00 , A61K8/44 , A61K8/49 , A61K8/64 , A61K31/195 , A61K31/198 , A61K31/381 , A61K38/08 , A61P17/00 , A61P17/04 , A61P37/08 , A61P43/00 , A61Q19/00
摘要： 痒みの新規標的分子を見出し、痒みの解消へ向けた新たな手段の提供。 Ｃ３ａ受容体拮抗剤を有効成分とする難治性痒みの予防又は改善剤。
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公开(公告)号：WO2022081041A1
公开(公告)日：2022-04-21
申请号：PCT/RU2021/000353
申请日：2021-08-12
IPC分类号： C07F7/30 , C07F19/00 , A61K31/28 , A61K31/19 , A61K31/195 , A61K31/198 , A61K33/00
摘要： Изобретение относится к комплексным соединениям германия общей формулы Ge[L]a[A]b[M]c, где L- ациклический полиол формулы (НОСН2[СН(ОН)]nСН2ОН), где n = 2, 3 или 4, А - аминокислота или гидроксикислота, М- катион металла, а = 1 или 2, b = 1, с = 0, когда А представляет аминокислоту, или с = 0 или 1, когда А представляет гидроксикислоту, и с не равно 0, соединение необязательно представляет собой этанольный сольват. Все L в соединении являются одинаковыми или разными. Заявленные комплексные соединения германия обладают антибактериальной активностью и могут быть использованы для профилактики или лечения заболеваний полости рта.
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7.发明申请
公开(公告)号：WO2022060987A1
公开(公告)日：2022-03-24
申请号：PCT/US2021/050677
申请日：2021-09-16
发明人： BRUCE, Simon , FOX, Jonathan , SANI-GROSSO, Ramei , KOMEYLI, Ali , SRIDHAR, Ananth , ROBERTS, Mary Scott
IPC分类号： A61K31/195 , A61P3/14
摘要： The present disclosure provides a method of treating an autosomal dominant hypocalcemia type 1 (ADH1) with a therapeutically effective amount of a compound of formula (I), in particular CLTX-305, wherein the therapeutically effective amount of the compound increases a blood calcium concentration (cCa) to a range of about 7.5 mg/dL to about 10.5 mg/dL, such as about 8.5 mg/dL to about 10.5 mg/dL. Also provided herein is a dosing finding method for treating an autosomal dominant hypocalcemia type 1 (ADH1) with a therapeutically effective amount of a compound of formula (I) or CLTX-305 according to one or more dosing regimens.
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公开(公告)号：WO2022050803A1
公开(公告)日：2022-03-10
申请号：PCT/KR2021/012074
申请日：2021-09-07
申请人： 한국생명공학연구원
IPC分类号： C07C311/33 , C07C311/38 , A61K31/18 , A61K31/195 , A61K31/216 , A61P35/04 , A61P19/02 , A61P29/00
摘要： 본 발명은 메틸설폰아미드계 유도체 화합물을 유효성분으로 함유하는 암전이 억제용 조성물에 관한 것이다. 보다 구체적으로, 본 발명의 화합물들이 CSE1L(chromosome segregation 1-like) 활성을 저해하고, 세포내 핵수송 기능을 억제함으로써 암세포의 이동 및/또는 침윤을 억제하여 암전이를 효과적으로 억제한다.
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9.发明申请
公开(公告)号：WO2022046870A1
公开(公告)日：2022-03-03
申请号：PCT/US2021/047499
申请日：2021-08-25
发明人： KIM, Jaeyeon
IPC分类号： A61K31/195 , A61K31/56 , A61K31/12 , A61K31/015 , A61P5/00 , A61P5/24 , A61P15/00 , A61P15/08
摘要： Disclosed are methods to prevent an occurrence of a high-grade serous ovarian cancer and/or breast cancer in a subject by administering a therapeutically effective amount of an antiprogestin to the subject.
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公开(公告)号：WO2022042583A1
公开(公告)日：2022-03-03
申请号：PCT/CN2021/114474
申请日：2021-08-25
申请人： 上海森辉医药有限公司 , 上海盛迪医药有限公司 , 江苏恒瑞医药股份有限公司
摘要： 一类载药的大分子及其制备方法。具体地，该大分子是负载药物及药代动力学修饰剂的树枝状聚合物，尤其涉及通过特定连接子将药物连接于树枝状聚合物。该类大分子可以用于对药物的释放速率进行调节，具体是通过连接子的选择进行的。
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