利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

63 条记录 (耗时 0.019 秒)

    SEPARATION OF VWF AND VWF PROPEPTIDE BY CHROMATOGRAPHIC METHODS
    4.
    发明申请
    SEPARATION OF VWF AND VWF PROPEPTIDE BY CHROMATOGRAPHIC METHODS 审中-公开

    公开(公告)号：WO2019183290A1

    公开(公告)日：2019-09-26

    申请号：PCT/US2019/023269

    申请日：2019-03-20

    申请人： BAXALTA INCORPORATED ,  BAXALTA GMBH

    发明人： FIEDLER, Christian ,  HASSLACHER, Meinhard ,  MAYER, Christa

    IPC分类号： C07K14/435

    摘要： The present invention relates to a method for separating a mature von Willebrand Factor (mat-VWF) from von Willebrand Factor pro-peptide (VWF-PP) by incubating a composition comprising inducing dissociation of mat-VWF and VWF-PP by disruption of the non- covalently associated mat-VWF and VWF-PP, wherein said dissociation is induced by: (i) addition of at least one chelating agent, or (ii) increasing the pH to a pH of at least 7, and then collecting said mat-VWF to obtain a high purity, propeptide depleted mature VWF (mat- VWF).

    USE OF ADAMTS13 FOR TREATING, AMELIORATING AND/OR PREVENTING VASO-OCCLUSIVE CRISIS IN SICKLE CELL DISEASE, ACUTE LUNG INJURY AND/OR ACUTE RESPIRATORY DISTRESS SYNDROME
    7.
    发明申请
    USE OF ADAMTS13 FOR TREATING, AMELIORATING AND/OR PREVENTING VASO-OCCLUSIVE CRISIS IN SICKLE CELL DISEASE, ACUTE LUNG INJURY AND/OR ACUTE RESPIRATORY DISTRESS SYNDROME 审中-公开
    使用ADAMTS13治疗，改善和/或预防镰状细胞病，急性肺损伤和/或急性呼吸窘迫综合征中的血管闭塞危象

    公开(公告)号：WO2018027169A1

    公开(公告)日：2018-02-08

    申请号：PCT/US2017/045573

    申请日：2017-08-04

    申请人： BAXALTA INCORPORATED ,  BAXALTA GMBH

    发明人： EWENSTEIN, Bruce ,  GOLDSTEIN, Brahm ,  MAJER, Bernhard ,  ROSSATO, Paolo ,  SCHEIFLINGER, Friedrich ,  TURECEK, Marietta

    IPC分类号： A61K38/48 ,  A61P7/02

    摘要： The disclosure provides compositions and methods for treating, ameliorating, and/or preventing a vaso-occlusive crisis (VOC) in a subject suffering from sickle cell disease (SCD). The disclosure also provides compositions and methods for treating, ameliorating, and/or preventing lung injury in a subject suffering from or at risk of suffering from acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). The disclosure provides A Disintegrin And Metalloproteinase with Thrombospondin type 1 motif, member- 13 (ADAMTS13) or a composition comprising ADAMTS13 for treating, ameliorating, and/or preventing the VOC, or for treating, ameliorating, and/or preventing lung injury in a subject suffering from or at risk of suffering from ALI and/or ARDS.

    摘要翻译： 本公开提供了用于治疗，改善和/或预防患有镰状细胞病（SCD）的受试者中的血管闭塞危象（VOC）的组合物和方法。 本公开内容还提供了用于治疗，改善和/或预防患有急性肺损伤（ALI）和/或急性呼吸窘迫综合征（ARDS）的受试者中的肺损伤的组合物和方法。 本公开内容提供了具有血小板反应蛋白1型基序的成分-13（ADAMTS13）或包含ADAMTS13的组合物用于治疗，改善和/或预防VOC，或用于治疗，改善和/或预防 患有ALI和/或ARDS或有患ALI和/或ARDS风险的受试者。

    GRIP DETECTION SYSTEM FOR LIQUID HANDLING ROBOT
    10.
    发明申请
    GRIP DETECTION SYSTEM FOR LIQUID HANDLING ROBOT 审中-公开

    公开(公告)号：WO2022025924A1

    公开(公告)日：2022-02-03

    申请号：PCT/US2020/044547

    申请日：2020-07-31

    申请人： BAXALTA INCORPORATED ,  BAXALTA GMBH

    发明人： WOLF, Ádám ,  MAJNERI, Paul

    IPC分类号： B25J9/16 ,  B25J19/02

    摘要： A liquid handling robot has a worktable that supports a rack holding a set of pipette tips. The liquid handling robot also has an arm that is operably suspended above the worktable, where the arm includes a tip receiver that is configured to engage the set of pipette tips. A controller of the liquid handling robot is configured to raise the tip receiver away from the worktable to withdraw the engaged set of pipette tips from the rack. A sensor is fixed relative to the worktable and is operable to emit a beam. A microcontroller monitors the sensor with the arm in a checking position to determine if the rack interrupts in the beam to indicate that the rack stuck to the pipette tips, which is autonomously resolved by the liquid handling robot performing a corrective action.