-
公开(公告)号:WO2020115283A1
公开(公告)日:2020-06-11
申请号:PCT/EP2019/084000
申请日:2019-12-06
申请人: BAXALTA GMBH , BAXALTA INCORPORATED , NOVIMMUNE SA
发明人: SCHEIFLINGER, Fritz , DOCKAL, Michael , DOUILLARD, Patrice , KERSCHBAUMER, Randolf , KNAPPE, Sabine , HARTMANN, Rudolf , FISCHER, Nicolas , GUENEAU, Franck , MAGISTRELLI, Giovanni , RAVN, Ulla
摘要: The present invention provides bispecific antibodies that bind to Factor IXa and Factor X and that have a procoagulant activity.
-
公开(公告)号:WO2020114615A1
公开(公告)日:2020-06-11
申请号:PCT/EP2018/084038
申请日:2018-12-07
申请人: BAXALTA GMBH , BAXALTA INCORPORATED , NOVIMMUNE SA
发明人: DOCKAL, Michael , FISCHER, Nicolas
摘要: The present invention provides bispecific antibodies that bind to Factor IXa and Factor X and that have a procoagulant activity.
-
公开(公告)号:WO2016025601A1
公开(公告)日:2016-02-18
申请号:PCT/US2015/044863
申请日:2015-08-12
申请人: BAXALTA INCORPORATED , BAXALTA GMBH
发明人: HASSLACHER, Meinhard , GATTERNIG, Thomas , FIEDLER, Christian , BOHM, Emst , DOCKAL, Michael , HORLING, Franziska
IPC分类号: C07K14/745 , C07K1/18 , C12N9/64
CPC分类号: C12N9/6432 , C12Y304/21006
摘要: Methods and systems for activating Factor X are disclosed
摘要翻译: 公开了用于激活因子X的方法和系统
-
公开(公告)号:WO2020114614A1
公开(公告)日:2020-06-11
申请号:PCT/EP2018/084037
申请日:2018-12-07
申请人: BAXALTA GMBH , BAXALTA INCORPORATED
发明人: DOCKAL, Michael
IPC分类号: C07K16/18 , C07K14/775 , C07K16/36 , A61P7/04 , A61K39/395 , C07K16/46
摘要: The present invention provides proteinaceous molecules that bind to Factor IXa and Factor X for enhancing a procoagulant activity.
-
5.PRODUCTION OF FULLY PROCESSED AND FUNCTIONAL FACTOR X IN A FURIN-SECRETING MAMMALIAN EXPRESSION SYSTEM 审中-公开
标题翻译: 在一个分泌的马马里亚表达系统中生产完全加工和功能因子X公开(公告)号:WO2016025615A1
公开(公告)日:2016-02-18
申请号:PCT/US2015/044883
申请日:2015-08-12
申请人: BAXALTA INCORPORATED , BAXALTA GMBH
IPC分类号: C12N9/64
CPC分类号: C12N15/85 , A61K38/4846 , C12N9/6432 , C12N9/6454 , C12Y304/21006 , C12Y304/21075
摘要: Disclosed herein are methods for production of fully-processed mature Factor X in an expression system producing a controlled amount of furin between 50 U/mL and 300 U/mL of culture supernatant. Also disclosed are transformed cells, expression systems, and expression vectors for the expression of furin and Factor X.
摘要翻译: 本文公开了在表达系统中产生完全加工的成熟因子X的方法,其产生受控量的弗林蛋白酶在50U / mL至300U / mL培养物上清液之间。 还公开了用于表达弗林蛋白酶和因子X的转化细胞,表达系统和表达载体。
-
公开(公告)号:WO2020115281A1
公开(公告)日:2020-06-11
申请号:PCT/EP2019/083998
申请日:2019-12-06
申请人: BAXALTA GMBH , BAXALTA INCORPORATED
发明人: SCHEIFLINGER, Fritz , KERSCHBAUMER, Randolf , DOCKAL, Michael , DOUILLARD, Patrice , KNAPPE, Sabine , HARTMANN, Rudolf , ISKENDERIAN, Andrea
IPC分类号: C07K16/18 , C07K14/775 , C07K16/36 , A61P7/04 , A61K39/395 , C07K16/46
摘要: The present invention provides proteinaceous molecules that bind to Factor IXa and Factor X for enhancing a procoagulant activity.
-
公开(公告)号:WO2016193200A1
公开(公告)日:2016-12-08
申请号:PCT/EP2016/062129
申请日:2016-05-30
申请人: BAXALTA INCORPORATED , BAXALTA GMBH
CPC分类号: G01N15/1463 , C12M47/04 , C12M47/12 , C12N5/0618 , G01N2015/1006 , G01N2015/1488
摘要: The present invention relates to a method for picking a colony of cells and to producing a cell line from this colony, as well as to the cell line thus established and to use of this cell line in a method for producing a biological molecule or biological entity of interest.
摘要翻译: 本发明涉及一种选择细胞集落和从该菌落生产细胞系的方法以及由此建立的细胞系以及在生物分子或生物体的制备方法中使用该细胞系 出于兴趣。
-
公开(公告)号:WO2015131061A1
公开(公告)日:2015-09-03
申请号:PCT/US2015/018041
申请日:2015-02-27
申请人: BAXALTA INCORPORATED , BAXALTA GMBH
发明人: DOCKAL, Michael , POLAKOWSKI, Thomas , OSTERKAMP, Frank , HARTMANN, Rudolf , PASCHKE, Matthias , HARTLIEB, Bettina , SCHEIFLINGER, Friedrich
IPC分类号: C07K14/745 , C07K7/08 , A61K38/00
CPC分类号: A61K38/10 , A61K38/00 , A61K47/60 , C07K7/08 , C07K14/745
摘要: The invention provides peptides, including peptides that bind and, optionally, inhibit Protein S, and compositions thereof. The peptides may be used to, e.g., inhibit Protein S activity, enhance thrombin formation in a subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify Protein S, and identify a Protein S binding compound.
摘要翻译: 本发明提供肽,包括结合并任选地抑制蛋白S的肽及其组合物。 肽可以用于例如抑制蛋白S活性,增强受试者中的凝血酶形成,增加受试者中的血块形成,治疗受试者的血液凝固障碍,纯化蛋白S,并鉴定蛋白S结合化合物。
-
-
-
-
-
-
-