公开(公告)号：WO2007041279A3

公开(公告)日：2007-09-27

申请号：PCT/US2006038028

申请日：2006-09-29

申请人： CELL BIOSCIENCES INC S ,  BEARDSLEY TERRY RAYMOND

发明人： BEARDSLEY TERRY RAYMOND

IPC分类号： A61K45/00

CPC分类号： A61K38/1709 ,  A61K38/012

摘要： T4 Immune Stimulating Factor (TISF) selectively induces aberrant T-cells to initiate apoptosis. TISF and peptides that are related to TiSF (TISF peptides) are therefore useful for the treatment of disorders characterized by aberrant production, development, or activity of T- cells or other cells of hematopoietic origin. This invention relates to methods of using TISF or a TISF peptide to treat such conditions, compositions containing TISF or a TISF peptide for use in such treatments, and use of TISF or a TISF peptide for the manufacture of pharmaceuticals .

摘要翻译： T4免疫刺激因子（TISF）选择性诱导异常T细胞引发细胞凋亡。 因此，与TiSF（TISF肽）相关的TISF和肽可用于治疗特征在于T细胞或造血起源的其他细胞异常产生，发育或活性的疾病。 本发明涉及使用TISF或TISF肽来治疗这些病症的方法，含有用于这种治疗的TISF或TISF肽的组合物，以及使用TISF或TISF肽来制造药物。

公开(公告)号：WO2008101037A1

公开(公告)日：2008-08-21

申请号：PCT/US2008/053891

申请日：2008-02-13

申请人： S-CELL BIOSCIENCES, INC. ,  BEARDSLEY, Terry, Raymond

发明人： BEARDSLEY, Terry, Raymond

IPC分类号： A61K39/395

CPC分类号： A61K38/18 ,  A61K8/91 ,  Y10S514/886

摘要： The present invention relates generally to the fields of pharmacology, and particularly to a method for treating inflammation, particularly inflammation of the respiratory system. The invention provides a method to reduce or ameliorate inflammation, by administering an effective amount of a protein factor originally isolated from thymic tissue, and referred to as T4 immune stimulating factor (TISF).

摘要翻译： 本发明一般涉及药理学领域，特别涉及用于治疗炎症，特别是呼吸系统炎症的方法。 本发明提供了通过施用有效量的最初从胸腺组织分离的蛋白因子（称为T4免疫刺激因子（TISF））来减轻或改善炎症的方法。

公开(公告)号：WO2007041279A2

公开(公告)日：2007-04-12

申请号：PCT/US2006/038028

申请日：2006-09-29

申请人： S-CELL BIOSCIENCES, INC. ,  BEARDSLEY, Terry, Raymond

发明人： BEARDSLEY, Terry, Raymond

IPC分类号： A61K38/17

CPC分类号： A61K38/1709 ,  A61K38/012

摘要： T4 Immune Stimulating Factor (TISF) selectively induces aberrant T-cells to initiate apoptosis. TISF and peptides that are related to TiSF (TISF peptides) are therefore useful for the treatment of disorders characterized by aberrant production, development, or activity of T- cells or other cells of hematopoietic origin. This invention relates to methods of using TISF or a TISF peptide to treat such conditions, compositions containing TISF or a TISF peptide for use in such treatments, and use of TISF or a TISF peptide for the manufacture of pharmaceuticals .

摘要翻译： T4免疫刺激因子（TISF）选择性诱导异常T细胞启动凋亡。 因此TISF和与TiSF相关的肽（TISF肽）因此可用于治疗以T细胞或造血起源的其他细胞的异常产生，发展或活性为特征的病症。 本发明涉及使用TISF或TISF肽来治疗这些病症的方法，包含用于此类治疗的TISF或TISF肽的组合物，以及TISF或TISF肽用于制造药物的用途。