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    CELL ADHESION PROTEINS AS BIOMARKER FOR ALZHEIMER'S DISEASE
    2.
    发明申请
    CELL ADHESION PROTEINS AS BIOMARKER FOR ALZHEIMER'S DISEASE 审中-公开
    细胞粘附蛋白作为ALZHEIMER病的生物标记

    公开(公告)号：WO2007140971A2

    公开(公告)日：2007-12-13

    申请号：PCT/EP2007/004944

    申请日：2007-06-04

    Applicant: F. HOFFMANN-LA ROCHE AG ,  BERNTENIS, Nikolaos ,  BOHRMANN, Bernd ,  GUENTERT, Andreas ,  MUELLER, Bernd

    Inventor： BERNTENIS, Nikolaos ,  BOHRMANN, Bernd ,  GUENTERT, Andreas ,  MUELLER, Bernd

    IPC: G01N33/68

    CPC classification number: G01N33/6896 ,  G01N2800/2821

    Abstract: The present invention relates to a method for assessing Alzheimer's Disease in vitro comprising measuring in a body fluid sample the level of one or more proteins of the group consisting of Myelin-associated glycoprotein precursor (MAG), Claudin-11, Contactin associated protein 1 precursor, Myelin oligodendrocyte glycoprotein precursor I (MOG), Contactin 1 precursor and Contactin 2 precursor, or a variant thereof, wherein an altered level of one of said proteins is indicative that said individual suffers from Alzheimer's Disease.

    Abstract translation: 本发明涉及一种体外评估阿尔茨海默氏病的方法，其包括在体液样品中测量由髓磷脂相关糖蛋白前体（MAG），紧密连接蛋白-11，接触蛋白相关蛋白1前体的一种或多种蛋白质的水平 ，髓鞘少突胶质细胞糖蛋白前体I（MOG），接触蛋白1前体和接触蛋白2前体或其变体，其中所述蛋白质之一的水平改变表明所述个体患有阿尔茨海默氏病。

    RA ANTIGENIC PEPTIDES
    4.
    发明申请
    RA ANTIGENIC PEPTIDES 审中-公开
    RA抗原肽

    公开(公告)号：WO2005014622A3

    公开(公告)日：2005-05-06

    申请号：PCT/EP2004008609

    申请日：2004-07-30

    Applicant: HOFFMANN LA ROCHE ,  BERNTENIS NIKOLAOS ,  BUURMAN GERRIT ,  KROPSHOFER HARALD ,  MUELLER BERND CHRISTIAN ,  SPINDELDREHER SEBASTIAN THOMAS ,  VOGT ANNE ,  ZOLG WERNER

    Inventor： BERNTENIS NIKOLAOS ,  BUURMAN GERRIT ,  KROPSHOFER HARALD ,  MUELLER BERND CHRISTIAN ,  SPINDELDREHER SEBASTIAN THOMAS ,  VOGT ANNE ,  ZOLG WERNER

    IPC: C07K14/47 ,  C07K14/74 ,  C07K1/22 ,  A61K38/00 ,  A61K39/00 ,  C07K1/32 ,  G01N33/569

    CPC classification number: C07K14/4713 ,  C07K14/70539

    Abstract: The present invention provides novel naturally-processed MHC class II antigenic peptides; which originate from interferon-gamma-inducible lysosomal thiol reductase, integrin beta-2, phosphatitylinositol-4,5-bisphosphate 3-kinase, urokinase-type plasminogen activator, immunoglobulin heavy chain V-III region (VH26), DJ-1 protein, apolipoprotein B-100, 26S proteasome non-ATPase regulatory subunit 8, interleukin-1 receptor, fibromodulin, GM-CSF/IL-3/IL-5 receptor, sorting nexin 3, inter-alpha-trypsin inhibitor heavy chain H4, complement C4, complement C3 (alpha-chain), complement C3 (beta-chain), SH3 domain-binding glutamic acid-rich-like protein 3, interleukin-4-induced protein 1, hemopexin, Hsc70-interacting protein,invariant chain (Ii), retinoic acid receptor responder protein 2, fibronectin, cathepsin B, tripeptidyl-peptidase II, legumain, platelet activating factor receptor, poly- alpha-2.8-sialyltransferase, and ras-leated protein Rab-11B. Also provided are these antigenic peptides and the proteins they are derived from as markers for erosive and/or non-erosive RA. Moreover, these antigenic peptides linked to MHC class II molecules, antibodies reactive with said antigenic peptides, nucleic acids encoding said antigenic peptides, and nucleic acid constructs, host cells and methods for expressing said antigenic peptides are provided. The antigenic peptides of the invention can be used as markers in diagnosis of RA and in therapy as anti-RA vaccines.

    Abstract translation: 本发明提供新型天然加工的MHC II类抗原肽; 来源于干扰素-γ诱导型溶酶体硫醇还原酶，整联蛋白β-2，磷脂酰肌醇-4,5-二磷酸3-激酶，尿激酶型纤溶酶原激活物，免疫球蛋白重链V-III区（VH26），DJ-1蛋白， 载脂蛋白B-100,26S蛋白酶体非ATPase调节亚单位8，白细胞介素-1受体，纤维调节蛋白，GM-CSF / IL-3 / IL-5受体，分选nexin 3，α间胰蛋白酶抑制剂重链H4，补体C4 ，补体C3（α链），补体C3（β链），SH3结构域结合谷氨酸样蛋白3，白细胞介素-4诱导的蛋白1，血红蛋白，Hsc70相互作用蛋白，不变链（Ii） ，视黄酸受体反应蛋白2，纤连蛋白，组织蛋白酶B，三肽基肽酶II，豆蔻酰胺，血小板活化因子受体，聚-α-2.8-唾液酸转移酶和ras-leated蛋白Rab-11B。 还提供了这些抗原肽和它们作为侵蚀性和/或非侵蚀性RA的标记物衍生的蛋白质。 此外，提供了与MHC II类分子连接的这些抗原肽，与所述抗原肽反应的抗体，编码所述抗原肽的核酸和核酸构建体，宿主细胞和用于表达所述抗原肽的方法。 本发明的抗原肽可用作RA诊断和抗RA疫苗治疗中的标志物。

    RA ANTIGENIC PEPTIDES
    7.
    发明申请
    RA ANTIGENIC PEPTIDES 审中-公开
    RA抗原肽

    公开(公告)号：WO2005014622A2

    公开(公告)日：2005-02-17

    申请号：PCT/EP2004/008609

    申请日：2004-07-30

    Applicant: F. HOFFMANN-LA ROCHE AG ,  BERNTENIS, Nikolaos ,  BUURMAN, Gerrit ,  KROPSHOFER, Harald ,  MUELLER, Bernd, Christian ,  SPINDELDREHER, Sebastian, Thomas ,  VOGT, Anne ,  ZOLG, Werner

    Inventor： BERNTENIS, Nikolaos ,  BUURMAN, Gerrit ,  KROPSHOFER, Harald ,  MUELLER, Bernd, Christian ,  SPINDELDREHER, Sebastian, Thomas ,  VOGT, Anne ,  ZOLG, Werner

    IPC: C07K1/22

    CPC classification number: C07K14/4713 ,  C07K14/70539

    Abstract: The present invention provides novel naturally-processed MHC class II antigenic peptides; which originate from interferon-γ-inducible lysosomal thiol reductase, integrin beta-2, phosphatitylinositol-4,5-bisphosphate 3-kinase, urokinase-type plasminogen activator, immunoglobulin heavy chain V-III region (V H 26), DJ-1 protein, apolipoprotein B-100, 26S proteasome non-ATPase regulatory subunit 8, interleukin-1 receptor, fibromodulin, GM-CSF/IL-3/IL-5 receptor, sorting nexin 3, inter-α-trypsin inhibitor heavy chain H4, complement C4, complement C3 (α-chain), complement C3 (β-chain), SH3 domain-binding glutamic acid-rich-like protein 3, interleukin-4-induced protein 1, hemopexin, Hsc70-interacting protein,invariant chain (Ii), retinoic acid receptor responder protein 2, fibronectin, cathepsin B, tripeptidyl-peptidase II, legumain, platelet activating factor receptor, poly- alpha-2.8-sialyltransferase, and ras-leated protein Rab-11B. Also provided are these antigenic peptides and the proteins they are derived from as markers for erosive and/or non-erosive RA. Moreover, these antigenic peptides linked to MHC class II molecules, antibodies reactive with said antigenic peptides, nucleic acids encoding said antigenic peptides, and nucleic acid constructs, host cells and methods for expressing said antigenic peptides are provided. The antigenic peptides of the invention can be used as markers in diagnosis of RA and in therapy as anti-RA vaccines.

    Abstract translation: 本发明提供了新的天然处理的MHC II类抗原肽; 其来源于干扰素-γ-诱导型溶酶体巯基还原酶，整联蛋白β-2，磷酸性肌醇-4,5-二磷酸3-激酶，尿激酶型纤溶酶原激活物，免疫球蛋白重链V-III区（V H 26），DJ-1蛋白，载脂蛋白B-100,26S蛋白酶体非ATP酶调节亚基8，白介素-1受体，纤调蛋白，GM-CSF / IL-3 / IL-5受体，nexin 3分选，α - 胰蛋白酶抑制剂重链H4，补体C4，补体C3（α-链），补体C3（β-链），SH3结构域结合谷氨酸富集样蛋白3，白细胞介素-4诱导蛋白1，血红素结合蛋白，Hsc70 - 相互作用蛋白，不变链（Ii），视黄酸受体响应蛋白2，纤连蛋白，组织蛋白酶B，三肽基肽酶II，legumain，血小板活化因子受体，聚-α-2.8-唾液酸转移酶和ras化的蛋白Rab-11B 。 还提供了这些抗原肽和它们来源于作为侵蚀性和/或非侵蚀性RA的标志物的蛋白质。 此外，提供了与MHC II类分子连接的这些抗原肽，与所述抗原肽反应的抗体，编码所述抗原肽的核酸，以及表达所述抗原肽的核酸构建体，宿主细胞和方法。 本发明的抗原性肽可以用作RA诊断和作为抗RA疫苗治疗的标记。

    CELL ADHESION PROTEINS AS BIOMARKER FOR ALZHEIMER'S DISEASE
    8.
    发明申请
    CELL ADHESION PROTEINS AS BIOMARKER FOR ALZHEIMER'S DISEASE 审中-公开
    细胞粘附蛋白作为ALZHEIMER病的生物标记

    公开(公告)号：WO2007140971A3

    公开(公告)日：2008-04-10

    申请号：PCT/EP2007004944

    申请日：2007-06-04

    Applicant: HOFFMANN LA ROCHE ,  BERNTENIS NIKOLAOS ,  BOHRMANN BERND ,  GUENTERT ANDREAS ,  MUELLER BERND

    Inventor： BERNTENIS NIKOLAOS ,  BOHRMANN BERND ,  GUENTERT ANDREAS ,  MUELLER BERND

    IPC: G01N33/68

    CPC classification number: G01N33/6896 ,  G01N2800/2821

    Abstract: The present invention relates to a method for assessing Alzheimer's Disease in vitro comprising measuring in a body fluid sample the level of one or more proteins of the group consisting of Myelin-associated glycoprotein precursor (MAG), Claudin-11, Contactin associated protein 1 precursor, Myelin oligodendrocyte glycoprotein precursor I (MOG), Contactin 1 precursor and Contactin 2 precursor, or a variant thereof, wherein an altered level of one of said proteins is indicative that said individual suffers from Alzheimer's Disease.

    Abstract translation: 本发明涉及一种体外评估阿尔茨海默氏病的方法，其包括在体液样品中测量由髓磷脂相关糖蛋白前体（MAG），紧密连接蛋白-11，接触蛋白相关蛋白1前体的一种或多种蛋白质的水平 ，髓鞘少突胶质细胞糖蛋白前体I（MOG），接触蛋白1前体和接触蛋白2前体或其变体，其中所述蛋白质之一的水平改变表明所述个体患有阿尔茨海默氏病。

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