公开(公告)号：WO2006081249A3

公开(公告)日：2006-08-03

申请号：PCT/US2006/002501

申请日：2006-01-25

Applicant: CELL THERAPEUTICS, INC. ,  BESMAN, Marc ,  CHIPMAN, Stewart ,  LEUNG, David

Inventor： BESMAN, Marc ,  CHIPMAN, Stewart ,  LEUNG, David

IPC: C07K14/435

Abstract: Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.

公开(公告)号：WO2006081249A9

公开(公告)日：2007-07-26

申请号：PCT/US2006002501

申请日：2006-01-25

Applicant: CELL THERAPEUTICS INC ,  BESMAN MARC ,  CHIPMAN STEWART ,  LEUNG DAVID ,  SINGER JACK

Inventor： BESMAN MARC ,  CHIPMAN STEWART ,  LEUNG DAVID ,  SINGER JACK

IPC: C07K14/435

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.

Abstract translation: 公开了生物活性蛋白质缀合物，其包含通过肽键与多肽偶联的生物活性多肽，所述多肽包含2至约500单位的重复肽基序，其中所述生物活性蛋白质缀合物与内在的 未缀合的生物活性多肽或蛋白质的半衰期。 还公开了制备和使用共轭蛋白的方法，以及用于确定给定缀合物相对于未缀合多肽的固有半衰期显示修饰的半衰期的方法。

公开(公告)号：WO2010054238A1

公开(公告)日：2010-05-14

申请号：PCT/US2009/063610

申请日：2009-11-06

Applicant: BAXTER INTERNATIONAL INC. ,  UNIVERSITY OF CONNECTICUT ,  PIKAL, Michael ,  TCHESSALOV, Serguei ,  BJORNSON, Erik ,  JAMEEL, Feroz ,  BESMAN, Marc

Inventor： PIKAL, Michael ,  TCHESSALOV, Serguei ,  BJORNSON, Erik ,  JAMEEL, Feroz ,  BESMAN, Marc

IPC: A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26 ,  A61K9/00 ,  A61K38/37

CPC classification number: A61K38/37 ,  A61K9/0019 ,  A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/183 ,  A61K47/20 ,  A61K47/26

Abstract: A Factor VIII (FVIII) composition formulated such that NaCl is not present in the final formulation or is present in trace amounts, which allows for a concomitant reduction in the lyophilization cycle time and increased stability of the lyophilized FVIII.

Abstract translation: 配制的因子VIII（FVIII）组合物使得NaCl不存在于最终制剂中或以微量存在，这允许冻干周期时间的伴随减少和冻干FVIII的稳定性增加。

公开(公告)号：WO2006081249A8

公开(公告)日：2007-09-13

申请号：PCT/US2006002501

申请日：2006-01-25

Applicant: CELL THERAPEUTICS INC ,  BESMAN MARC ,  CHIPMAN STEWART ,  LEUNG DAVID ,  SINGER JACK

Inventor： BESMAN MARC ,  CHIPMAN STEWART ,  LEUNG DAVID ,  SINGER JACK

IPC: C07K14/435

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.

Abstract translation: 公开了包含生物活性蛋白质缀合物的生物活性蛋白质缀合物，所述生物活性多肽通过肽键与包含2至约500个重复肽基序单元的多肽偶联，其中所述生物活性蛋白质缀合物显示与内源性相比改变的血浆半衰期 未缀合的生物活性多肽或蛋白质的半衰期。 还公开了制备和使用缀合蛋白的方法，以及用于确定给定缀合物是否表现出相对于未缀合多肽的内在半衰期的修饰半衰期的方法。

公开(公告)号：WO2006081249A2

公开(公告)日：2006-08-03

申请号：PCT/US2006002501

申请日：2006-01-25

Applicant: CELL THERAPEUTICS INC ,  BESMAN MARC ,  CHIPMAN STEWART ,  LEUNG DAVID

Inventor： BESMAN MARC ,  CHIPMAN STEWART ,  LEUNG DAVID

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.

Abstract translation: 公开了生物活性蛋白质缀合物，其包含通过肽键与多肽偶联的生物活性多肽，所述多肽包含2至约500个单位的重复肽基序，其中所述生物活性蛋白质缀合物与内在的 未缀合的生物活性多肽或蛋白质的半衰期。 还公开了制备和使用共轭蛋白的方法，以及用于确定给定缀合物相对于未缀合多肽的固有半衰期显示修饰的半衰期的方法。