公开(公告)号：WO2010111528A2

公开(公告)日：2010-09-30

申请号：PCT/US2010028722

申请日：2010-03-25

Applicant: ABBOTT MEDICAL OPTICS INC ,  VAN DER MOOREN MARRIE H ,  BOGAERT THEOPHILUS ,  JAIN RAKHI

Inventor： VAN DER MOOREN MARRIE H ,  BOGAERT THEOPHILUS ,  JAIN RAKHI

IPC: A61F9/007

CPC classification number: A61F9/00781

Abstract: A method of treating glaucoma in an eye by managing fluid flow past an implanted shunt having an elastomeric plate and a non-valved elastomeric drainage tube. The plate is positioned over a sclera of the eye with an outflow end of the elastomeric drainage tube open to an outer face of the plate. An inflow end of the drainage tube tunnels through the sclera to the anterior chamber of the eye. The plate may have regions of greater propensity for cell adhesion alternating with regions of lesser cell adhesion. For example, regions of texturing around the plate or drainage tube may be provided to control the size of a bleb that forms over the implant. The effective surface area of the plate may be balanced against a number of fenestrations. The drainage tube has a reduced profile and may be shaped with a non-circular external cross-section to reduce its height. A scleral groove may be used to further reduce the height of the drainage tube on the sclera. A flow restrictor for the early post operative period will immediately lower the intraocular pressure (IOP) and simultanously prevent hypotony.

Abstract translation: 通过管理流体流过具有弹性体板和非瓣膜弹性体引流管的植入分流器来治疗眼睛中的青光眼的方法。 该板位于眼睛的巩膜上方，弹性体排出管的流出端向板的外表面敞开。 引流管的入流端通过巩膜隧道进入眼睛的前房。 该板可以具有较高的细胞粘附倾向的区域与较小细胞粘附的区域交替。 例如，可以提供围绕板或引流管的纹理区域以控制在植入物上形成的泡沫的尺寸。 板的有效表面积可以与多个开窗平衡。 排水管具有减小的轮廓并且可以被成形为具有非圆形的外部横截面以减小其高度。 可以使用巩膜槽来进一步降低巩膜上引流管的高度。 术后早期流量限制器将立即降低眼内压（IOP）并同时预防低血压。

公开(公告)号：WO2009029515A1

公开(公告)日：2009-03-05

申请号：PCT/US2008/073999

申请日：2008-08-22

Applicant: ADVANCED MEDICAL OPTICS, INC. ,  BOGAERT, Theophilus

Inventor： BOGAERT, Theophilus

IPC: A61F2/16

CPC classification number: A61F2/141 ,  A61F2/1602 ,  A61F2/1613 ,  A61F2/1618 ,  A61F2/164

Abstract: An intraocular lens for providing enhanced vision includes an optic with a clear aperture over which light may be focused onto or near the retina of an eye. The optic includes an anterior surface and an opposing posterior surface, the surfaces disposed about an optical axis. The optic includes a central zone and an outer zone disposed about the central zone. The central zone comprises a plurality of optical powers that progressively vary between a first optical power at a center of the central zone and a second optical power at a periphery of the central zone, wherein the absolute value of the difference between the first optical power and the second optical power being between predetermined values. The outer zone comprises a third optical power and may also have a negative spherical aberration. The optic typically has a variation in optical power over the entire clear aperture that is less than a predetermined amount.

Abstract translation: 用于提供增强视力的眼内透镜包括具有透明孔的光学元件，光可以聚焦在眼睛的视网膜上或附近。 光学元件包括前表面和相对的后表面，所述表面围绕光轴设置。 光学元件包括中心区域和围绕中心区域设置的外部区域。 中心区域包括多个光功率，其在中心区域的中心处的第一光焦度和中心区域的周边处的第二光焦度之间逐渐变化，其中第一光焦度与第二光焦度之间的差的绝对值 第二光功率在预定值之间。 外部区域包括第三光焦度并且还可以具有负球面像差。 光学器件通常在整个透明孔径上具有小于预定量的光功率变化。

公开(公告)号：WO2009039299A3

公开(公告)日：2009-03-26

申请号：PCT/US2008/076886

申请日：2008-09-18

Applicant: ADVANCED MEDICAL OPTICS, INC. ,  AVERY, Neal ,  BOGAERT, Theophilus

Inventor： AVERY, Neal ,  BOGAERT, Theophilus

IPC: B29D11/00 ,  B29D11/02

Abstract: Method for partially coating intraocular lenses by masking a portion of the lens, plasma treating, applying a coating to the lens and removing the masking.

公开(公告)号：WO2014140849A3

公开(公告)日：2014-09-18

申请号：PCT/IB2014/000982

申请日：2014-03-10

Applicant: AMO GRONINGEN B.V. ,  BOGAERT, Theophilus

Inventor： BOGAERT, Theophilus

IPC: A61B3/10 ,  A61F9/02 ,  A61B3/028 ,  G02B27/01 ,  A61B3/00 ,  A61F9/008

Abstract: Embodiments of this invention relate to the generation of wavefronts for measurements, diagnostics, and treatment planning for ophthalmic applications. In some embodiments, a wavefront generator generates light having a uniform wavefront, which is focusable on the retina of an emmetropic eye by the normal function of the emmetropic eye. In some embodiments, the wavefront generator can generate light having a custom wavefront which is not focusable on the retina of the emmetropic eye. In some embodiments, the wavefront generator can receive information relating to an optical aberration of the eye, generate a custom wavefront, and project light having this custom wavefront, which in combination with the optical aberration of the eye is focusable on the retina.

公开(公告)号：WO2014140849A2

公开(公告)日：2014-09-18

申请号：PCT/IB2014000982

申请日：2014-03-10

Applicant: AMO GRONINGEN BV ,  BOGAERT THEOPHILUS

Inventor： BOGAERT THEOPHILUS

IPC: A61B3/10

CPC classification number: A61B3/0025 ,  A61B3/0041 ,  A61B3/028 ,  A61B3/1015 ,  A61F9/008 ,  A61F2009/0088 ,  G02B27/017 ,  G02B2027/011 ,  G02B2027/0138 ,  G02B2027/014 ,  G02B2027/0178 ,  G02C2202/10

Abstract: Embodiments of this invention relate to the generation of wavefronts for measurements, diagnostics, and treatment planning for ophthalmic applications. In some embodiments, a wavefront generator generates light having a uniform wavefront, which is focusable on the retina of an emmetropic eye by the normal function of the emmetropic eye. In some embodiments, the wavefront generator can generate light having a custom wavefront which is not focusable on the retina of the emmetropic eye. In some embodiments, the wavefront generator can receive information relating to an optical aberration of the eye, generate a custom wavefront, and project light having this custom wavefront, which in combination with the optical aberration of the eye is focusable on the retina.

Abstract translation: 本发明的实施例涉及用于眼科应用的测量，诊断和治疗计划的波前的产生。 在一些实施例中，波前发生器产生具有均匀波前的光，其通过正视眼的正常功能聚焦在正视眼的视网膜上。 在一些实施例中，波前发生器可以产生具有不能对准正视眼的视网膜的自定义波前的光。 在一些实施例中，波前发生器可以接收与眼睛的光学像差有关的信息，产生自定义波前，以及投射具有该自定义波前的光，其结合眼睛的光学像差可聚焦在视网膜上。

公开(公告)号：WO2010111528A8

公开(公告)日：2011-04-21

申请号：PCT/US2010028722

申请日：2010-03-25

Applicant: ABBOTT MEDICAL OPTICS INC ,  VAN DER MOOREN MARRIE H ,  BOGAERT THEOPHILUS ,  JAIN RAKHI

Inventor： VAN DER MOOREN MARRIE H ,  BOGAERT THEOPHILUS ,  JAIN RAKHI

IPC: A61F9/007

CPC classification number: A61F9/00781

Abstract: An implantable glaucoma shunt (10) for treating glaucoma in an eye by managing fluid flow past an implanted shunt having an elastomeric plate (40) and a non-valved elastomeric drainage tube (46). The plate is positioned over a sclera of the eye with an outflow end (50) of the elastomeric drainage tube open to an outer face of the plate (42). An inflow (52) end of the drainage tube tunnels through the sclera to the anterior chamber of the eye. The plate may have regions of greater propensity for cell adhesion alternating with regions of lesser cell adhesion. For example, regions of texturing around the plate or drainage tube may be provided to control the size of a bleb that forms over the implant. The effective surface area of the plate may be balanced against a number of fenestrations (64). The drainage tube has a reduced profile and may be shaped with a non-circular external cross - section to reduce its height. A scleral groove may be used to further reduce the height of the drainage tube on the sclera. A flow restrictor for the early post operative period will immediately lower the intraocular pressure (IOP) and simultanously prevent hypotony.

公开(公告)号：WO2009039299A2

公开(公告)日：2009-03-26

申请号：PCT/US2008076886

申请日：2008-09-18

Applicant: ADVANCED MEDICAL OPTICS INC ,  AVERY NEAL ,  BOGAERT THEOPHILUS

Inventor： AVERY NEAL ,  BOGAERT THEOPHILUS

IPC: B29D11/00 ,  B29D11/02

CPC classification number: B29D11/00865 ,  A61F2/16 ,  A61F2/1613 ,  A61F2002/1681 ,  B29D11/023

Abstract: An atmospheric pressure chemical vapor deposition apparatus has been developed for partially coating acrylic based intraocular lenses. In one embodiment intraocular lenses may be coated with a hydrophilic material comprising silicone dioxide and polyethylene glycol. In another embodiment the haptics may be coated with hydrophilic material, which aids in the post implantation unfolding of the lenses whiie not diminishing posterior bag adhesion of the hydrophobic surface of the untreated optic portion.

Abstract translation: 已经开发了用于部分涂覆丙烯酸类眼内透镜的大气压化学气相沉积设备。 在一个实施方案中，眼内透镜可以涂覆有包含二氧化硅和聚乙二醇的亲水材料。 在另一个实施例中，触觉件可以用亲水材料涂覆，这有助于透镜的后植入展开，而不会减少未处理的光学部分的疏水表面的后袋粘附。

公开(公告)号：WO2012006385A2

公开(公告)日：2012-01-12

申请号：PCT/US2011/043119

申请日：2011-07-07

Applicant: ABBOTT MEDICAL OPTICS INC. ,  BOGAERT, Theophilus ,  WEEBER, Hendrik, A. ,  ZHAO, Huawei

Inventor： BOGAERT, Theophilus ,  WEEBER, Hendrik, A. ,  ZHAO, Huawei

IPC: A61F2/16

CPC classification number: A61F2/1654 ,  A61B3/0025 ,  A61F2/1645 ,  A61F9/013 ,  A61F2002/1699 ,  G02B3/06 ,  G02B27/0075 ,  G02C7/02 ,  G02C7/027 ,  G02C7/041 ,  G02C7/06 ,  G02C2202/02 ,  G02C2202/06 ,  G02C2202/20

Abstract: A method, system and apparatus for vision correction are disclosed. The method, system and apparatus include a toric intraocular element for correcting astigmatism and having a cylinder power, and a depth of focus extender coupled to the toric intraocular element, the depth of focus extender extending a depth of focus. The extended depth of focus may reduce sensitivity of the toric intraocular element to at least one of rotation and selected cylinder power.

Abstract translation: 公开了一种用于视力矫正的方法，系统和设备。 该方法，系统和设备包括用于校正散光并具有柱面光焦度的复曲面眼内元件以及耦合到复曲面眼内元件的焦深扩展器，焦深扩展器延伸焦点深度。 扩大的焦点深度可以降低复曲面眼内元件对旋转和选择的柱面能量中的至少一种的灵敏度。

公开(公告)号：WO2012006385A3

公开(公告)日：2012-03-29

申请号：PCT/US2011043119

申请日：2011-07-07

Applicant: ABBOTT MEDICAL OPTICS INC ,  BOGAERT THEOPHILUS ,  WEEBER HENDRIK A ,  ZHAO HUAWEI

Inventor： BOGAERT THEOPHILUS ,  WEEBER HENDRIK A ,  ZHAO HUAWEI

IPC: A61F2/16 ,  G02C7/04 ,  G02C7/08

CPC classification number: A61F2/1654 ,  A61B3/0025 ,  A61F2/1645 ,  A61F9/013 ,  A61F2002/1699 ,  G02B3/06 ,  G02B27/0075 ,  G02C7/02 ,  G02C7/027 ,  G02C7/041 ,  G02C7/06 ,  G02C2202/02 ,  G02C2202/06 ,  G02C2202/20

Abstract: A method, system and apparatus for vision correction are disclosed. The method, system and apparatus include a toric intraocular element for correcting astigmatism and having a cylinder power, and a depth of focus extender coupled to the toric intraocular element, the depth of focus extender extending a depth of focus. The extended depth of focus may reduce sensitivity of the toric intraocular element to at least one of rotation and selected cylinder power.

Abstract translation: 公开了一种用于视力矫正的方法，系统和装置。 该方法，系统和装置包括用于矫正散光并具有圆柱体动力的复曲面眼内元件，以及耦合到复曲面眼内元件的聚焦延伸器的深度聚焦延伸器延伸焦点深度。 扩大的焦点深度可以将复曲面眼内元件的灵敏度降低到旋转和选择的气缸功率中的至少一个。

公开(公告)号：WO2010111528A3

公开(公告)日：2011-03-24

申请号：PCT/US2010028722

申请日：2010-03-25

Applicant: ABBOTT MEDICAL OPTICS INC ,  VAN DER MOOREN MARRIE H ,  BOGAERT THEOPHILUS ,  JAIN RAKHI

Inventor： VAN DER MOOREN MARRIE H ,  BOGAERT THEOPHILUS ,  JAIN RAKHI

IPC: A61F9/007

CPC classification number: A61F9/00781

Abstract: An implantable glaucoma shunt (10) for treating glaucoma in an eye by managing fluid flow past an implanted shunt having an elastomeric plate (40) and a non-valved elastomeric drainage tube (46). The plate is positioned over a sclera of the eye with an outflow end (50) of the elastomeric drainage tube open to an outer face of the plate (42). An inflow (52) end of the drainage tube tunnels through the sclera to the anterior chamber of the eye. The plate may have regions of greater propensity for cell adhesion alternating with regions of lesser cell adhesion. For example, regions of texturing around the plate or drainage tube may be provided to control the size of a bleb that forms over the implant. The effective surface area of the plate may be balanced against a number of fenestrations (64). The drainage tube has a reduced profile and may be shaped with a non-circular external cross - section to reduce its height. A scleral groove may be used to further reduce the height of the drainage tube on the sclera. A flow restrictor for the early post operative period will immediately lower the intraocular pressure (IOP) and simultanously prevent hypotony.

Abstract translation: 一种用于通过管理流体流过具有弹性体板（40）和无阀弹性体引流管（46）的植入分流器来治疗眼内青光眼的可植入青光眼分流器（10）。 该板位于眼睛的巩膜上方，弹性引流管的流出端（50）通向板（42）的外表面。 引流管的流入端（52）通过巩膜隧道到眼前房。 该板可以具有较高细胞粘附倾向的区域与较少细胞粘附的区域交替。 例如，可以提供围绕平板或引流管的纹理区域以控制在植入物上形成的气泡的大小。 板的有效表面积可以与多个窗孔（64）平衡。 引流管具有减小的外形并且可以成形为具有非圆形外部横截面以降低其高度。 可以使用巩膜凹槽来进一步减小巩膜上引流管的高度。 手术后早期的限流器将立即降低眼压（IOP）并同时防止低眼压。