公开(公告)号：WO2014179568A2

公开(公告)日：2014-11-06

申请号：PCT/US2014/036370

申请日：2014-05-01

Applicant: ODIN BIOTECH

Inventor： CSAKY, Karl

IPC: A61K9/00 ,  B29D11/02

CPC classification number: A61K9/0051 ,  A61F2/14 ,  A61F9/0017 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2240/00 ,  A61F2240/004 ,  A61F2250/0067 ,  A61K31/26 ,  A61L27/18 ,  A61L2430/16 ,  B29D11/023 ,  B29K2083/00 ,  C08L83/04

Abstract: The present invention generally relates to local therapies for the eye and, more particularly, to shaped controlled-release ocular implant devices, including methods for making and using such devices, for delivery of therapeutic agents to the eye. A molded two-layer ocular implant comprises a therapeutic agent for treatment or prevention of a disorder of the eye. The implant comprises a polymer layer and a silicone adhesive layer with a therapeutic agent interspersed therein and joined to the polymer layer. This implant is for placement in the sub-Tenons space of the eye and provides sustained release of the therapeutic agent during the treatment or prevention of the disorder of the eye.

Abstract translation: 本发明一般涉及用于眼睛的局部治疗，更具体地说，涉及成形的控制释放眼部植入装置，包括制造和使用这些装置的方法，用于将治疗剂递送至眼睛。 模制的双层眼部植入物包括用于治疗或预防眼睛疾病的治疗剂。 植入物包括聚合物层和具有散布在其中并与聚合物层连接的治疗剂的硅氧烷粘合剂层。 该植入物用于放置在眼睛的子Tenon空间中并且在治疗或预防眼睛疾病期间提供治疗剂的持续释放。

公开(公告)号：WO2014099345A1

公开(公告)日：2014-06-26

申请号：PCT/US2013/072746

申请日：2013-12-03

Applicant: NOVARTIS AG ,  CARSON, Daniel R. ,  LEE, Shinwook

Inventor： CARSON, Daniel R. ,  LEE, Shinwook

IPC: A61F2/16

CPC classification number: B29D11/023 ,  A61F2/1624 ,  A61F2/1635 ,  A61F2/1648

Abstract: An accommodative intraocular lens (IOL) system is disclosed for insertion into an eye to provide accommodative vision, the system including a deformable air chamber filled with a transparent, low refractive index medium disposed between the first and second optics; and at least one haptic connected to the air chamber and configured to facilitate a change in the curvature of at least one surface of the chamber, such that when the lens system is positioned in an eye, cilliary muscle movements can alter the curvature of the air chamber and vary the overall lens power of the system.

Abstract translation: 公开了一种用于插入眼睛以提供调节视力的调节性眼内透镜（IOL）系统，该系统包括填充有设置在第一和第二光学器件之间的透明低折射率介质的可变形空气室; 以及至少一个触觉件，其连接到所述空气室并且被配置为促进所述腔室的至少一个表面的曲率的改变，使得当所述透镜系统定位在眼睛中时，所述肌肉运动可以改变所述空气的曲率 并改变系统的整体透镜功率。

公开(公告)号：WO2010135685A1

公开(公告)日：2010-11-25

申请号：PCT/US2010/035832

申请日：2010-05-21

Applicant: ABBOTT MEDICAL OPTICS INC. ,  BUMBALOUGH, Timothy, R. ,  GERAGHTY, Edward ,  BRADY, Daniel, G.

Inventor： BUMBALOUGH, Timothy, R. ,  GERAGHTY, Edward ,  BRADY, Daniel, G.

IPC: A61F2/16

CPC classification number: A61F2/1613 ,  A61F2/1616 ,  A61F2/1618 ,  A61F2/1648 ,  A61F2002/1681 ,  A61F2002/1699 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0053 ,  B29D11/023

Abstract: An ophthalmic lens (100) for providing enhanced vision includes a finished optic (105) comprising a base optic (115) and a shell (135). The base optic has an anterior surface (120) and an opposing posterior surface (125), at least one of the surfaces having a first value of a surface quality parameter. The shell includes a membrane (140, 150) including an inner surface and an outer surface, the inner surface covering one or more of the surfaces of the base optic. The outer surface has a second value of the surface quality parameter, wherein the second value is greater than the first value.

Abstract translation: 用于提供增强视觉的眼用透镜（100）包括包括基底光学元件（115）和外壳（135）的成品光学元件（105）。 基部光学元件具有前表面（120）和相对的后表面（125），至少一个表面具有表面质量参数的第一值。 壳体包括包括内表面和外表面的膜（140,150），内表面覆盖基底光学元件的一个或多个表面。 外表面具有表面质量参数的第二值，其中第二值大于第一值。

公开(公告)号：WO2006121876A3

公开(公告)日：2009-04-23

申请号：PCT/US2006017441

申请日：2006-05-05

Applicant: KEY MEDICAL TECHNOLOGIES INC ,  MENTAK KHALID

Inventor： MENTAK KHALID

IPC: G02B1/04 ,  C08J7/00

CPC classification number: B29D11/023 ,  A61F2/1613 ,  A61F2/1659 ,  A61F2002/1696 ,  A61F2250/0053 ,  B29D11/00634

Abstract: Intraocular lenses are manufactured with a higher concentration of blue light blocking chromophores at the center of the lens than at the periphery. Manufacturing involves creating a core by polymerization having a higher concentration of the blue light blocking chromophores, and then polymerizing around the core material a polymer sleeve or tube containing a lesser amount of chromophore. In the second polymerization step some of the chromophore migrates from the higher concentration core to the lesser concentration perimeter material, creating a uniform gradient.

Abstract translation: 在透镜的中心处制造具有较高浓度的蓝光阻挡发色团的人工晶状体，而不是外围。 制造包括通过具有较高浓度的蓝光阻挡发色团的聚合产生核心，然后在核心材料周围聚合含有较少量发色团的聚合物套管或管。 在第二聚合步骤中，一些发色团从较高浓度的核心迁移到较小浓度的周边材料，产生均匀的梯度。

公开(公告)号：WO2007127400A3

公开(公告)日：2008-05-29

申请号：PCT/US2007010292

申请日：2007-04-28

Applicant: INNOVIA LLC ,  PINCHUK LEONARD

Inventor： PINCHUK LEONARD

IPC: A61F2/16

CPC classification number: B29D11/00009 ,  A61L27/14 ,  A61L2400/06 ,  A61L2430/16 ,  B29D11/023

Abstract: Polymeric materials and methods that realize a gel-type intraocular lens that is formed in situ within the lens capsule of the eye. The polymeric material of the intraocular lens includes reactive end groups that effectively bond with lens capsule walls, thus eliminating space between the intraocular lens and the lens capsule walls and significantly reducing the proliferation of lens epithelial cells which can cause unwanted posterior capsule opacification. In another aspect, various polymers are provided that can be polymerized in the lens capsule with the ability to bond an intraocular lens implant to the posterior capsule of the eye such that there is no space available between the intraocular lens implant and the lens capsule for lens epithelial cells to proliferate and thereby significantly reducing posterior capsule opacification.

Abstract translation: 实现在眼睛晶状体囊内原位形成的凝胶型眼内透镜的聚合材料和方法。 眼内透镜的聚合物材料包括有效地与透镜胶囊壁结合的反应性端基，从而消除了眼内透镜和晶状体囊壁之间的空间，并显着减少了可能引起不想要的后囊混浊的晶状体上皮细胞的增殖。 在另一方面，提供了可以在透镜胶囊中聚合的各种聚合物，其具有将眼内透镜植入物结合到眼后囊的能力，使得在眼内透镜植入物和晶状体囊之间没有可用的空间 上皮细胞增殖，从而显着降低后囊混浊。

公开(公告)号：WO2006113595A2

公开(公告)日：2006-10-26

申请号：PCT/US2006/014356

申请日：2006-04-13

Applicant: INTRALENS VISION, INC. ,  MILLER, Troy A. ,  CUNANAN, Crystal M. ,  VATZ, Alexander

Inventor： MILLER, Troy A. ,  CUNANAN, Crystal M. ,  VATZ, Alexander

IPC: A61F2/14 ,  B29D11/00

CPC classification number: A61F2/16 ,  A61F2/147 ,  B29D11/00028 ,  B29D11/023 ,  G02C7/02

Abstract: The implantable lenses described herein provide for modified edge regions. In one example embodiment an implantable lens includes an anterior surface, a posterior surface and an outer edge surface separating the anterior and posterior surfaces. The anterior surface can include a corrective portion and a beveled portion. The beveled portion can be located between the corrective portion and the outer edge surface. The outer edge surface can have a first portion and a second portion, where the first portion abuts the posterior surface and the second portion, and where the second portion further abuts the beveled portion. The modified edge region provides a more gradual transition between the anterior and posterior surfaces.

Abstract translation: 本文所述的可植入透镜提供了修改的边缘区域。 在一个示例性实施例中，可植入透镜包括前表面，后表面和分离前表面和后表面的外边缘表面。 前表面可以包括校正部分和斜面部分。 斜切部分可以位于校正部分和外边缘表面之间。 外边缘表面可以具有第一部分和第二部分，其中第一部分邻接后表面和第二部分，并且其中第二部分还邻接斜面部分。 改进的边缘区域在前表面和后表面之间提供更渐进的过渡。

公开(公告)号：WO2006113290A1

公开(公告)日：2006-10-26

申请号：PCT/US2006/013730

申请日：2006-04-12

Applicant: BENZ RESEARCH & DEVELOPMENT CORPORATION ,  BENZ, Patrick, H. ,  ORS, Jose, A.

Inventor： BENZ, Patrick, H. ,  ORS, Jose, A.

IPC: B29D11/00 ,  A61F2/16

CPC classification number: A61L27/00 ,  A61F2/16 ,  A61L27/16 ,  A61L2430/16 ,  B29D11/023 ,  C08F22/14 ,  C08F220/28 ,  C08F222/1006 ,  C08F2220/281 ,  G02B1/041 ,  C08L33/14

Abstract: The present invention provides optic portions, intraocular lenses, and polymers for use in manufacturing optic portions and intraocular lenses. The optic portions include a polymer that comprises (a) one or more alkoxyalkyl methacrylate monomers and/or one or more alkoxyalkyl acrylate monomers that are incorporated in the polymer; (b) one or more hydroxyalkyl methacrylate monomers and/or one or more hydroxyalkyl acrylate monomers that are incorporated in the polymer; and (c) optionally, one or more crosslinking agents that are incorporated in the polymer.

Abstract translation: 本发明提供用于制造光学部分和眼内透镜的光学部分，眼内透镜和聚合物。 光学部分包括聚合物，其包含（a）一种或多种甲基丙烯酸烷氧基烷基酯单体和/或一种或多种掺入聚合物中的丙烯酸烷氧基烷基酯单体; （b）一种或多种甲基丙烯酸羟烷基酯单体和/或一种或多种掺入聚合物中的丙烯酸羟烷基酯单体; 和（c）任选地，引入聚合物中的一种或多种交联剂。

公开(公告)号：WO2006004707A2

公开(公告)日：2006-01-12

申请号：PCT/US2005/022841

申请日：2005-06-22

Applicant: BAUSCH & LOMB INCORPORATED ,  RICHARDSON, Gary, A. ,  FOOS, Ted ,  HOVEY, Larry, C.

Inventor： RICHARDSON, Gary, A. ,  FOOS, Ted ,  HOVEY, Larry, C.

IPC: B29D11/02

CPC classification number: B29D11/023 ,  A61F2/1648 ,  A61F2240/004 ,  B29C47/0021 ,  B29C47/0038 ,  B29C69/001 ,  B29D11/026

Abstract: A method, lens and assembly are disclosed for making a dual optic AIOL from a lens blank having first and second optics and at least one haptic extending therebetween larger in area than the haptic(s) of the finished AIOL. Material is removed from the semi-finished haptic to form the finished haptic of any desired configuration.

Abstract translation: 公开了一种用于由具有第一和第二光学器件的透镜毛坯制造双光学AIOL的方法，透镜和组件，以及至少一个在它们之间延伸的触感，其面积比成品的触觉更大 AIOL。 材料从半成品触觉中移除，以形成任何所需配置的成品触觉。

公开(公告)号：WO2005019871A2

公开(公告)日：2005-03-03

申请号：PCT/US2004/025129

申请日：2004-08-03

Applicant: OPHTHALMIC INNOVATIONS INTERNATIONAL ,  PORTNEY, Valdemar ,  HORVATICH, Donald, A. ,  GARCIA, Victor, M.

Inventor： PORTNEY, Valdemar ,  HORVATICH, Donald, A. ,  GARCIA, Victor, M.

IPC: G02B

CPC classification number: A61F2/1648 ,  A61F2/16 ,  A61F2002/1681 ,  A61F2002/1686 ,  A61F2220/0033 ,  A61F2250/0018 ,  B29C65/56 ,  B29C65/58 ,  B29C66/30325 ,  B29C66/71 ,  B29D11/023 ,  B29L2011/0041 ,  B29K2021/00

Abstract: A multi-piece intraocular lens (IOL) has an optic constructed of an elastomeric plastic and an opposing pair of attachment members (haptics) constructed of a rigid plastic material. The optic or haptics have one or more small, tear drop-shaped, inlet recesses formed into each from a peripheral edge region. The haptics or optic are formed having peripheral edge protuberances matching in size, shape and position corresponding optic or haptic inlet recesses. The protuberances dovetail into the corresponding inlet recesses and are cemented therein to lock the haptics and optic together. Methods for manufacturing a multi-piece IOL include forming the haptics from a modified haptic blank and the optic from a modified optic blank. After the haptic or optic protuberances are dovetailed and cemented into the optic or haptic inlet recesses, the haptics and optic are milled or lathed from the respective haptic and optic blanks to provide a completed multi-piece IOL.

Abstract translation: 多件式人工晶状体（IOL）具有由弹性体塑料构成的光学部件和由刚性塑料材料构成的相对的一对附连部件（触觉部分）。 光学器件或触觉件具有一个或多个小的泪滴状入口凹陷，其从外围边缘区域形成。 触觉件或光学件形成为具有与尺寸，形状和位置相匹配的对应于光学或触觉入口凹陷的周缘突起。 突起嵌入相应的入口凹槽中，并粘合在其中以将触件和光学器件锁定在一起。 用于制造多件式IOL的方法包括由经修改的触觉毛坯形成触觉件并且从经修改的光学坯件形成光学件。 在触觉或光学突起接合并粘合到视觉或触觉入口凹槽后，触觉和光学器件从相应的触觉和视觉空白研磨或车削，以提供完整的多件式IOL。

公开(公告)号：WO02004196A1

公开(公告)日：2002-01-17

申请号：PCT/US2001/021673

申请日：2001-07-09

IPC: A61F2/16 ,  B29C59/16 ,  B29D11/02 ,  B29D11/00 ,  C23F1/04

CPC classification number: A61F2/14 ,  A61F2/16 ,  A61F2240/001 ,  A61L27/18 ,  B29C59/16 ,  B29D11/023 ,  B29K2995/0056 ,  B29K2995/0073 ,  B29L2011/0016 ,  H01J2237/0812

Abstract: Atomic level surface smoothing utilizing GCIB (100) to smooth and round the IOL's (10) outer edges to reduce the "edge effect" and its resultant glare. In addition, the present invention provides, atomic level surface smoothing utilizing GCIB (100) to smooth the IOL's (10) posterior and/or anterior surfaces to improve the adhesion of the IOL (10) to the capsule, preventing cell in-growth and their resultant secondary cataract. The GCIB (100) smoothed surfaces will also reduce inflammatory response by reducing foreign particles on the surface and by reducing the microroughness normally inherent on the IOL (10) surface.

Abstract translation: 使用GCIB（100）平滑和旋转IOL（10）外缘的原子水平表面平滑度，以减少“边缘效应”及其产生的眩光。 此外，本发明提供了利用GCIB（100）平滑IOL（10）后表面和/或前表面的原子水平表面平滑，以改善IOL（10）对胶囊的粘附，防止细胞生长和 其产生的继发性白内障。 GCIB（100）平滑的表面也将通过减少表面上的异物和减少IOL（10）表面上通常固有的微粗糙度来减少炎症反应。