公开(公告)号：WO2012041292A2

公开(公告)日：2012-04-05

申请号：PCT/DE2011001779

申请日：2011-09-20

Applicant: KLINIKUM DARMSTADT GMBH ,  UNIV MUENCHEN L MAXIMILIANS ,  UNIV DARMSTADT TECH ,  SCHMIDT BORIS ,  KIESER DANIEL ,  BOLAENDER ALEXANDER ,  HERMS JOCHEN ,  HEYNY-VON HAUSSEN ROLAND HANS

Inventor： SCHMIDT BORIS ,  KIESER DANIEL ,  BOLAENDER ALEXANDER ,  HERMS JOCHEN ,  HEYNY-VON HAUSSEN ROLAND HANS

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0039 ,  C07D209/12 ,  C07D239/26 ,  C07D271/12 ,  C07D403/06 ,  C07D417/12 ,  C07D417/14 ,  G01N2800/28

Abstract: The invention relates to compounds having high affinity for the Aß protein, a-synuclein, or PHF-tau aggregates, wherein said compounds are suitable as preferably fluorescent probes for the in vivo diagnosis of neurodegenerative diseases such as Alzheimer's disease, dementia, and Parkinson's disease. The compounds are characterized by suitable physiochemical properties (excitation wavelength, emission wavelength, Stokes shift, extinction) and high affinity and selectivity for the target proteins.

Abstract translation: 本发明涉及一种具有用于屁股蛋白，α-突触核蛋白或用于PHF tau聚集，其适合于神经变性疾病的体内诊断优选作为荧光探针，例如，高亲和力的化合物 阿尔茨海默氏症和帕金森克罗恩病。 化合物由适当的物理化学性质（激发波长，荧光波长，Stokes位移，吸光度）以及高亲和力和选择性的靶蛋白为特征。

公开(公告)号：WO2012037928A3

公开(公告)日：2013-04-25

申请号：PCT/DE2011001780

申请日：2011-09-20

Applicant: KLINIKUM DARMSTADT GMBH ,  UNIV MUENCHEN L MAXIMILIANS ,  UNIV DARMSTADT TECH ,  SCHMIDT BORIS ,  KIESER DANIEL ,  BOLAENDER ALEXANDER ,  HERMS JOCHEN ,  HEYNY-VON HAUSSEN ROLAND HANS ,  GU JIAMIN

Inventor： SCHMIDT BORIS ,  KIESER DANIEL ,  BOLAENDER ALEXANDER ,  HERMS JOCHEN ,  HEYNY-VON HAUSSEN ROLAND HANS ,  GU JIAMIN

IPC: G01N33/68 ,  A61K31/33 ,  A61K49/00 ,  C07D211/00 ,  C07D403/00 ,  C07D417/00

CPC classification number: A61K49/0021 ,  A61K31/426 ,  A61K31/428 ,  A61K31/4965 ,  A61K31/505 ,  A61K49/0039 ,  C07D403/00 ,  C07D403/02 ,  C07D403/14 ,  C07D417/00 ,  C07D417/02 ,  G01N21/6428 ,  G01N33/6896 ,  G01N2800/28

Abstract: The present invention relates to compounds having a high affinity for the Abeta protein, alpha-synuclein or for Tau-PHF aggregates, which are suitable as preferably fluorescent probes for the in-vivo diagnosis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. The compounds are distinguished by suitable physiochemical properties (excitation wavelength, emission wavelength, Stokes shift, extinction) and also high affinity and selectivity for the target proteins.

Abstract translation: 本发明涉及与用于屁股蛋白，α-突触核蛋白或用于PHF-tau聚集的高亲和性，其疾病优选适合作为用于神经变性的体内诊断，例如荧光探针化合物 阿尔茨海默氏症和帕金森氏症。 化合物由适当的物理化学性质（激发波长，荧光波长，Stokes位移，吸光度）以及高亲和力和选择性的靶蛋白为特征。