公开(公告)号：WO2012172005A1

公开(公告)日：2012-12-20

申请号：PCT/EP2012/061316

申请日：2012-06-14

Applicant: Istituto Nazionale di Genetica Molecolare - INGM ,  BOMBACI, Mauro ,  ABRIGNANI, Sergio ,  ZINGARETTI, Chiara

Inventor： BOMBACI, Mauro ,  ABRIGNANI, Sergio ,  ZINGARETTI, Chiara

IPC: G01N33/564 ,  G01N33/576

CPC classification number: G01N33/6893 ,  G01N33/564 ,  G01N2800/085

Abstract: The present invention relates to a method for diagnosis or prognosis of liver autoimmune diseases by means of detecting specific biomarkers in biological samples. The invention refers also to a method of monitoring an autoimmune liver disease pathology status after treatment with surgery and/or therapy in a subject with autoimmune liver disease, to kits and microarrays to perform said methods.

Abstract translation: 本发明涉及通过检测生物样品中的特定生物标志物来诊断或预测肝脏自身免疫性疾病的方法。 本发明还涉及在患有自身免疫性肝病的受试者中用手术和/或治疗进行治疗后监测自身免疫性肝病病理状态的方法，试剂盒和微阵列以执行所述方法。

公开(公告)号：WO2012172004A1

公开(公告)日：2012-12-20

申请号：PCT/EP2012/061313

申请日：2012-06-14

Applicant: Istituto Nazionale Genetica Molecolare - INGM ,  BOMBACI, Mauro ,  ABRIGNANI, Sergio ,  ZINGARETTI, Chiara

Inventor： BOMBACI, Mauro ,  ABRIGNANI, Sergio ,  ZINGARETTI, Chiara

IPC: G01N33/564 ,  G01N33/576

CPC classification number: G01N33/6893 ,  G01N33/564 ,  G01N2800/085

Abstract: The present invention relates to a method for diagnosis or prognosis of liver autoimmune diseases by means of detecting specific biomarkers in biological samples. The invention refers also to a method of monitoring an autoimmune liver disease pathology status after treatment with surgery and/or therapy in a subject with autoimmune liver disease, to kits and microarrays to perform said methods.

Abstract translation: 本发明涉及一种通过检测生物样品中特异性生物标志物来诊断或预后肝脏自身免疫疾病的方法。 本发明还涉及在具有自身免疫性肝病的受试者中用手术和/或治疗治疗后监测自身免疫性肝病病理状态的方法，以及用于实施所述方法的试剂盒和微阵列。

公开(公告)号：WO2010100627A1

公开(公告)日：2010-09-10

申请号：PCT/IB2010/050967

申请日：2010-03-05

Applicant: NOVARTIS AG ,  OREFICI, Graziella ,  BENSI, Giuliano ,  GRIFANTINI, Renata ,  MARGARIT Y ROS, Immaculada ,  GRANDI, Guido ,  BOMBACI, Mauro

Inventor： OREFICI, Graziella ,  BENSI, Giuliano ,  GRIFANTINI, Renata ,  MARGARIT Y ROS, Immaculada ,  GRANDI, Guido ,  BOMBACI, Mauro

IPC: G01N33/68

CPC classification number: G01N33/56944 ,  G01N33/6896 ,  G01N2333/315 ,  G01N2800/2835 ,  G01N2800/50

Abstract: This invention provides a method of identifying GAS infection as the cause of a neuropsychiatric or behavioural disorder in a patient, or of identifying a patient at risk of developing a neuropsychiatric or behavioural disorder caused by GAS infection. This invention also provides associated protein arrays.

Abstract translation: 本发明提供了鉴定GAS感染作为患者神经精神障碍或行为障碍的原因或识别患有由GAS感染引起的神经精神病或行为障碍的风险的患者的方法。 本发明还提供了相关的蛋白质阵列。