公开(公告)号：WO03003983A3

公开(公告)日：2003-09-04

申请号：PCT/US0221103

申请日：2002-07-02

Applicant: SYNAPTIC PHARMA CORP ,  BOROWSKY BETH E ,  QUAN YONG ,  SMITH KELLI E

Inventor： BOROWSKY BETH E ,  QUAN YONG ,  SMITH KELLI E

IPC: C07K14/705 ,  A61K38/00 ,  A61K38/18 ,  A61K45/00

CPC classification number: C07K14/70567

Abstract: This invention provides a method of treating a subject suffering from an abnormality which comprises administering to the subject an amount of a SNORF11 receptor agonist effective to treat the subject's abnormality. This invention further provides a method of treating pain, particularly chronic pain, chronic inflammatory pain and arthritic pain, which comprises administering to the subject an amount of a SNORF11 receptor agonist effective to treat the subject's pain.

Abstract translation: 本发明提供了治疗患有异常的受试者的方法，其包括向受试者施用一定量的有效治疗受试者异常的SNORF11受体激动剂。 本发明还提供了治疗疼痛，特别是慢性疼痛，慢性炎性疼痛和关节炎疼痛的方法，其包括向受试者施用一定量的有效治疗受试者的疼痛的SNORF11受体激动剂。

公开(公告)号：WO2003003983A2

公开(公告)日：2003-01-16

申请号：PCT/US2002/021103

申请日：2002-07-02

Applicant: SYNAPTIC PHARMACEUTICAL CORPORATION ,  BOROWSKY, Beth, E. ,  QUAN, Yong ,  SMITH, Kelli, E.

Inventor： BOROWSKY, Beth, E. ,  QUAN, Yong ,  SMITH, Kelli, E.

IPC: A61K

CPC classification number: C07K14/70567

Abstract: This invention provides a method of treating a subject suffering from an abnormality which comprises administering to the subject an amount of a SNORF11 receptor agonist effective to treat the subject's abnormality. This invention further provides a method of treating pain, particularly chronic pain, chronic inflammatory pain and arthritic pain, which comprises administering to the subject an amount of a SNORF11 receptor agonist effective to treat the subject's pain.

Abstract translation: 本发明提供了治疗患有异常的受试者的方法，该方法包括给受试者施用有效治疗受试者异常的量的SNORF11受体激动剂。 本发明进一步提供了治疗疼痛，尤其是慢性疼痛，慢性炎性疼痛和关节炎疼痛的方法，其包括向所述对象施用有效治疗所述对象疼痛的量的SNORF11受体激动剂。

公开(公告)号：WO0073449B1

公开(公告)日：2001-03-01

申请号：PCT/US0014654

申请日：2000-05-26

Applicant: SYNAPTIC PHARMA CORP ,  BOROWSKY BETH E ,  OGOZALEK KRISTINE L ,  JONES KENNETH A

Inventor： BOROWSKY BETH E ,  OGOZALEK KRISTINE L ,  JONES KENNETH A

IPC: A01K67/027 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10 ,  A61P3/12 ,  A61P5/00 ,  A61P5/06 ,  A61P7/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P15/00 ,  A61P19/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/06 ,  A61P25/18 ,  A61P25/20 ,  A61P25/28 ,  A61P27/02 ,  A61P37/00 ,  A61P43/00 ,  C07K14/705 ,  C07K16/28 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/566 ,  C07K14/47 ,  C12P21/02 ,  G01N33/53 ,  G01N33/567

CPC classification number: C07K14/705 ,  A61K38/00 ,  A61K48/00

Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.

Abstract translation: 本发明提供编码哺乳动物SNORF33受体的分离的核酸，纯化的哺乳动物SNORF33受体，包含编码哺乳动物SNORF33受体的核酸的载体，包含此类载体的细胞，针对哺乳动物SNORF33受体的抗体，用于检测编码哺乳动物SNORF33受体的核酸的核酸探针， 与编码哺乳动物SNORF33受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变的哺乳动物SNORF33受体的DNA的转基因非人动物，分离哺乳动物SNORF33受体的方法，治疗与哺乳动物的活性相关的异常的方法 SNORF33受体以及确定化合物与哺乳动物SNORF33受体结合的方法，识别SNORF33受体的激动剂和拮抗剂的方法，以及如此确定的激动剂和拮抗剂。