公开(公告)号：WO2010075545A1

公开(公告)日：2010-07-01

申请号：PCT/US2009/069465

申请日：2009-12-23

Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A. ,  JOHNSON, David A. ,  EVANS, Jay T. ,  HUTTON, Melinda M. ,  BOWEN, William S. ,  MINNS, Laurie A.

Inventor： JOHNSON, David A. ,  EVANS, Jay T. ,  HUTTON, Melinda M. ,  BOWEN, William S. ,  MINNS, Laurie A.

IPC: A61K45/00 ,  A61K47/00

CPC classification number: A61K39/39 ,  A61K31/661 ,  A61K31/665 ,  A61K45/06 ,  A61K2039/55572 ,  A61K2300/00

Abstract: The use of a selected aminoalkyl glusoaminide 4-phosphate (AGP) CRX-547 to induce a TRIF biased response in a human system, which results in reduced levels of MyD88-dependent cytokines relative to the MyD88-dependent cytokines induced by its diastereomer AGP CRX-527.

Abstract translation: 选择的氨基烷基葡聚糖苷-4-磷酸（AGP）CRX-547在人体系中诱导TRIF偏向反应的使用，其导致相对于由其非对映体AGP CRX诱导的MyD88依赖性细胞因子降低的MyD88依赖性细胞因子水平 -527。