公开(公告)号：WO2008110351A3

公开(公告)日：2008-09-18

申请号：PCT/EP2008/001965

申请日：2008-03-12

Applicant: DOMPE' PHA.R.MA S.P.A. ,  CANTARINI, Marco ,  GENTILE, Marco

Inventor： CANTARINI, Marco ,  GENTILE, Marco

IPC: A61K31/165 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61P31/00

Abstract: The present invention relates to the use of amides of (R) and (S)-2-aryl- propionic acids as antiseptic agents. The present invention also provides a pharmaceutical preparation including compounds of formula (I), having antiseptic properties for the treatment of gastrointestinal, muco-epidermal and epidermal infections. The present invention is related to pharmaceutical compositions containing an antiseptic agent carried in a suitable vehicle to provide mouthwashes, tablets, solutions, gels, creams and others. The formulations are applied topically to sites of gastrointestinal, muco-epidermal or epidermal infections. Compounds of present invention can be useful in the treatment of nausea, vomiting, bloating, diarrhea, constipation and oropharyngeal, esophageal, vaginal, rectal, nasal and other mucosal infections.

公开(公告)号：WO2008110351A2

公开(公告)日：2008-09-18

申请号：PCT/EP2008001965

申请日：2008-03-12

Applicant: DOMPE PHA R MA SPA RES & MFG ,  CANTARINI MARCO ,  GENTILE MARCO

Inventor： CANTARINI MARCO ,  GENTILE MARCO

IPC: A61K31/165 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61P31/00

CPC classification number: A61K31/165 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453

Abstract: The present invention relates to the use of amides of (R) and (S)-2-aryl- propionic acids as antiseptic agents. The present invention also provides a pharmaceutical preparation including compounds of formula (I), having antiseptic properties for the treatment of gastrointestinal, muco-epidermal and epidermal infections. The present invention is related to pharmaceutical compositions containing an antiseptic agent carried in a suitable vehicle to provide mouthwashes, tablets, solutions, gels, creams and others. The formulations are applied topically to sites of gastrointestinal, muco-epidermal or epidermal infections. Compounds of present invention can be useful in the treatment of nausea, vomiting, bloating, diarrhea, constipation and oropharyngeal, esophageal, vaginal, rectal, nasal and other mucosal infections.

Abstract translation: 本发明涉及（R）和（S）-2-芳基 - 丙酸的酰胺作为防腐剂的用途。 本发明还提供了包含式（I）化合物的药物制剂，其具有用于治疗胃肠道，粘膜表皮和表皮感染的防腐性质。 本发明涉及含有在合适的载体中携带的防腐剂以提供漱口剂，片剂，溶液，凝胶，霜剂等的药物组合物。 将制剂局部施用于胃肠道，粘膜表皮或表皮感染的部位。 本发明化合物可用于治疗恶心，呕吐，腹胀，腹泻，便秘和口咽，食管，阴道，直肠，鼻和其他粘膜感染。

公开(公告)号：WO2009000473A2

公开(公告)日：2008-12-31

申请号：PCT/EP2008/004993

申请日：2008-06-20

Applicant: DOMPE PHA.R.MA S.P.A. ,  GENTILE, Marco ,  CANTARINI, Marco

Inventor： GENTILE, Marco ,  CANTARINI, Marco

IPC: A61K31/573 ,  A61K9/46 ,  A61K9/72

CPC classification number: A61K31/573 ,  A61K9/0007 ,  A61K9/0078 ,  A61K9/2009

Abstract: The present invention relates to the use of effervescent tablets containing insoluble active principles for the preparation of a suspension for inhalatory use that retain the primary particle size of the drug substance. The tablets dissolve in the solution until a fine suspension is obtained. The suspension maintains the initial particle size distribution of the drug substance, ensuring the achievement of the therapeutic window of the aspired fraction.

Abstract translation: 本发明涉及含有不溶性活性成分的泡腾片剂用于制备保留药物物质一次粒径的吸入用悬浮液。 片剂溶于溶液中直到获得细小的悬浮液。 悬浮液维持药物物质的初始粒度分布，确保达到预期成分的治疗窗口。

公开(公告)号：WO2009000473A3

公开(公告)日：2009-07-30

申请号：PCT/EP2008004993

申请日：2008-06-20

Applicant: DOMPE PHA R MA SPA RES & MFG ,  GENTILE MARCO ,  CANTARINI MARCO

Inventor： GENTILE MARCO ,  CANTARINI MARCO

IPC: A61K9/46 ,  A61K9/72 ,  A61K31/573

CPC classification number: A61K31/573 ,  A61K9/0007 ,  A61K9/0078 ,  A61K9/2009

Abstract: The present invention relates to the use of effervescent tablets containing insoluble active principles for the preparation of a suspension for inhalatory use that retain the primary particle size of the drug substance. The tablets dissolve in the solution until a fine suspension is obtained. The suspension maintains the initial particle size distribution of the drug substance, ensuring the achievement of the therapeutic window of the aspired fraction.

Abstract translation: 本发明涉及含有不溶性活性成分的泡腾片剂用于制备保留药物物质一次粒径的吸入用悬浮液。 片剂溶于溶液中直到获得细小的悬浮液。 悬浮液维持药物物质的初始粒度分布，确保达到预期成分的治疗窗口。