公开(公告)号：WO2008120140A1

公开(公告)日：2008-10-09

申请号：PCT/IB2008/051129

申请日：2008-03-26

Applicant: KIMBERLY-CLARK WORLDWIDE, INC. ,  KOENIG, David, W. ,  HOFFMAN, Douglas, R. ,  CARNEY, Sara

Inventor： KOENIG, David, W. ,  HOFFMAN, Douglas, R. ,  CARNEY, Sara

IPC: A61L2/02 ,  A61L2/025 ,  A61L2/03 ,  A61L2/18

CPC classification number: A61L2/025 ,  A61L2/02 ,  A61L2/035 ,  A61L2/18

Abstract: The present disclosure generally relates to methods for disinfecting surfaces. More particularly, the present disclosure relates to methods for destroying prion molecules using a combination of ultrasonic energy and enzyme treatment that is effective to denature and degrade prion proteins.

Abstract translation: 本发明一般涉及消毒表面的方法。 更具体地，本公开涉及使用超声能量和酶处理的组合来破坏朊病毒分子的方法，其有效地使朊蛋白变性和降解。

公开(公告)号：WO2009016535A2

公开(公告)日：2009-02-05

申请号：PCT/IB2008052883

申请日：2008-07-17

Applicant: KIMBERLY CLARK CO ,  CARNEY SARA ,  KOENIG DAVID WILLIAM ,  BEGAWALA JUNAID

Inventor： CARNEY SARA ,  KOENIG DAVID WILLIAM ,  BEGAWALA JUNAID

IPC: A61M5/00

CPC classification number: C11D3/386 ,  A61M2025/0019 ,  C11D3/222 ,  C11D11/0041

Abstract: The present disclosure is directed to methods and compositions for clearing and cleaning enteral feeding tubes. More particularly, the composition is an ingestible gel composition that comprises enzymes for degrading buildup in enteral feeding tubes, carrageenan, and divalent metal ions or a source thereof. The carrageenan present in the composition stabilizes the enzymes at room temperatures, allowing for long-term storage of the composition. Upon injecting the gelled composition into the feeding tube, body heat from the patient melts the gel, and the enzymes are released to act on debris present in the feeding tube.

Abstract translation: 本公开涉及用于清洁和清洁肠内营养管的方法和组合物。 更具体地说，该组合物是一种可摄入的凝胶组合物，其包含用于降解肠内饲养管中积聚的酶，角叉菜胶和二价金属离子或其来源。 存在于组合物中的角叉菜胶在室温下稳定酶，允许组合物的长期储存。 一旦将凝胶化的组合物注入饲管中，来自患者的体热使凝胶熔化，并且酶被释放以作用于饲管中存在的碎屑。

公开(公告)号：WO2007078412A1

公开(公告)日：2007-07-12

申请号：PCT/US2006/043006

申请日：2006-11-03

Applicant: KIMBERLY-CLARK WORLDWIDE, INC. ,  HUDSON, Tammy, McFall ,  KOENIG, David, William ,  SCHORR, Phillip, Andrew ,  HOFFMAN, Douglas, Robert ,  CARNEY, Sara, Ann ,  KROLL, Lisa, M.

Inventor： HUDSON, Tammy, McFall ,  KOENIG, David, William ,  SCHORR, Phillip, Andrew ,  HOFFMAN, Douglas, Robert ,  CARNEY, Sara, Ann ,  KROLL, Lisa, M.

IPC: A61L2/26 ,  A61L2/18 ,  A41D13/11 ,  A41D13/12 ,  A41D19/00 ,  A41D31/00 ,  A61B19/04 ,  A61B19/08

CPC classification number: A41D31/0077 ,  A41D13/1192 ,  A41D31/0083 ,  A41D2400/34 ,  A61B42/00 ,  A61B46/00 ,  A61B2017/00889 ,  A61L2/186 ,  A61L2/208 ,  A61L2/22 ,  A61L2/26 ,  A61L2202/24 ,  A61L2202/26 ,  Y10T442/2525

Abstract: A germicidal surface-covering assembly that includes at least two different donnable or drapable garments. Each garment defines at least one treated surface that is susceptible to pathogen contamination in a physical contamination event when used as intended in an environment subject to contamination (e.g., a clinical environment, a laboratory or a workplace). Each treated surface is adapted to provide a time-dependent reduction in the number of pathogens available at that treated surface after a physical contamination event, such that at least a predetermined time after a physical contamination event at a first location on a first treated surface of a first garment, a first physical contact between the first location on the first treated surface and a second location on a second treated surface of a second garment results fewer viable pathogens on the second treated surface as compared to an untreated control. Moreover, at least a predetermined time after the first physical contact, a second physical contact between the second location on the second treated surface and a third location on a third treated surface of a third garment results in fewer viable pathogens on the third treated surface as compared to an untreated control.

Abstract translation: 一种杀菌表面覆盖组件，其包括至少两种不同的不可穿戴的或可悬挂的衣服。 每个衣服限定至少一个经处理的表面，当在受污染的环境（例如临床环境，实验室或工作场所）中使用时，物理污染事件易受病原体污染。 每个经处理的表面适于在物理污染事件之后提供在该处理过的表面上可获得的病原体数量的时间依赖性减少，使得在第一处理的表面上的第一位置处的物理污染事件之后的至少预定时间 与未处理的对照相比，第一衣服，第一处理的表面上的第一位置和第二衣服的第二处理的表面上的第二位置之间的第一物理接触导致在第二处理的表面上较少的活的病原体。 此外，在第一物理接触之后的至少预定时间内，第二处理表面上的第二位置与第三衣服的第三处理表面上的第三位置之间的第二物理接触在第三处理的表面上导致较少的活病原体，如 与未处理的对照相比。

公开(公告)号：WO2010070483A2

公开(公告)日：2010-06-24

申请号：PCT/IB2009/055106

申请日：2009-11-16

Applicant: KIMBERLY-CLARK WORLDWIDE, INC. ,  HOFFMAN, Douglas, Robert ,  SMILTNEEK, Andrea, Jo ,  CARNEY, Sara, Ann ,  WENZEL, Scott, W. ,  KOENIG, David, William ,  SEIDLING, Jeffery, Richard

Inventor： HOFFMAN, Douglas, Robert ,  SMILTNEEK, Andrea, Jo ,  CARNEY, Sara, Ann ,  WENZEL, Scott, W. ,  KOENIG, David, William ,  SEIDLING, Jeffery, Richard

IPC: B32B27/00 ,  A61L15/44 ,  A61L15/48 ,  A61F13/02

CPC classification number: A61K9/7007 ,  A61K9/0024 ,  A61K31/00 ,  A61L15/22 ,  A61L15/44 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/61

Abstract: The present disclosure comprises a polymeric substrate that provides multiple releases of active agents. A substrate for multiple phase delivery of active agents is provided having a first polymer matrix layer having a first active agent disposed therein, a second polymer matrix layer having a second active agent disposed therein, and a coacervate layer disposed between the first polymer matrix layer and the second polymer matrix layer. Selected first and second active agents are included in the first and second polymer matrices such that as the first and second polymer matrices dissolve, the active agents are released. Multiple phase active agent release is achieved by constructing multiple layers of a polymer matrix containing an active agents formed with polymers having different solubility characteristics or with active agents at different concentration levels.

Abstract translation: 本公开包含提供多次释放的活性剂的聚合物基材。 提供了一种用于多相递送活性剂的基质，其具有设置在其中的第一活性剂的第一聚合物基质层，其中设置有第二活性剂的第二聚合物基质层和设置在第一聚合物基质层和第二聚合物基质层之间的凝聚层 第二聚合物基质层。 选定的第一和第二活性剂包含在第一和第二聚合物基质中，使得随着第一和第二聚合物基质溶解，活性剂被释放。 多相活性剂释放通过构建多层聚合物基质来实现，所述聚合物基质含有由具有不同溶解度特征的聚合物形成的活性剂或者以不同浓度水平的活性剂。

公开(公告)号：WO2009016535A3

公开(公告)日：2009-02-05

申请号：PCT/IB2008/052883

申请日：2008-07-17

Applicant: KIMBERLY-CLARK WORLDWIDE, INC. ,  CARNEY, Sara ,  KOENIG, David William ,  BEGAWALA, Junaid

Inventor： CARNEY, Sara ,  KOENIG, David William ,  BEGAWALA, Junaid

IPC: A61M5/00

Abstract: The present disclosure is directed to methods and compositions for clearing and cleaning enteral feeding tubes. More particularly, the composition is an ingestible gel composition that comprises enzymes for degrading buildup in enteral feeding tubes, carrageenan, and divalent metal ions or a source thereof. The carrageenan present in the composition stabilizes the enzymes at room temperatures, allowing for long-term storage of the composition. Upon injecting the gelled composition into the feeding tube, body heat from the patient melts the gel, and the enzymes are released to act on debris present in the feeding tube.

公开(公告)号：WO2010070483A3

公开(公告)日：2010-09-02

申请号：PCT/IB2009055106

申请日：2009-11-16

Applicant: KIMBERLY CLARK CO ,  HOFFMAN DOUGLAS ROBERT ,  SMILTNEEK ANDREA JO ,  CARNEY SARA ANN ,  WENZEL SCOTT W ,  KOENIG DAVID WILLIAM ,  SEIDLING JEFFERY RICHARD

Inventor： HOFFMAN DOUGLAS ROBERT ,  SMILTNEEK ANDREA JO ,  CARNEY SARA ANN ,  WENZEL SCOTT W ,  KOENIG DAVID WILLIAM ,  SEIDLING JEFFERY RICHARD

IPC: B32B27/00 ,  A61F13/02 ,  A61L15/44 ,  A61L15/48

CPC classification number: A61K9/7007 ,  A61K9/0024 ,  A61K31/00 ,  A61L15/22 ,  A61L15/44 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/61

Abstract: The present disclosure comprises a polymeric substrate that provides multiple releases of active agents. A substrate for multiple phase delivery of active agents is provided having a first polymer matrix layer having a first active agent disposed therein, a second polymer matrix layer having a second active agent disposed therein, and a coacervate layer disposed between the first polymer matrix layer and the second polymer matrix layer. Selected first and second active agents are included in the first and second polymer matrices such that as the first and second polymer matrices dissolve, the active agents are released. Multiple phase active agent release is achieved by constructing multiple layers of a polymer matrix containing an active agents formed with polymers having different solubility characteristics or with active agents at different concentration levels.

Abstract translation: 本公开内容包括提供活性剂多次释放的聚合物基质。 提供一种用于多相递送活性剂的底物，其具有设置在其中的第一活性剂的第一聚合物基质层，其中设置有第二活性剂的第二聚合物基质层和设置在第一聚合物基质层和第二聚合物基质层之间的凝聚层， 第二聚合物基质层。 选择的第一和第二活性剂包括在第一和第二聚合物基质中，使得当第一和第二聚合物基质溶解时，活性剂被释放。 通过构建多层含有由不同溶解度特征的聚合物形成的活性剂或具有不同浓度水平的活性剂形成的聚合物基质来实现多相活性剂释放。