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6 条记录 (耗时 0.012 秒)

    MEDICAL TUBE
    1.
    发明申请
    MEDICAL TUBE 审中-公开
    医疗管

    公开(公告)号：WO2017075021A1

    公开(公告)日：2017-05-04

    申请号：PCT/US2016/058814

    申请日：2016-10-26

    申请人： CELANESE EVA PERFORMANCE POLYMERS CORPORATION

    发明人： ZHANG, Bin ,  HALEY, Jeffrey C. ,  HAIR, Dirk ,  REYES, Jose ,  KIM, Sung Hye

    IPC分类号： C08F2/00 ,  C08F218/08 ,  C08F2/06

    CPC分类号： C08L23/0853 ,  A61M25/0021 ,  C08L2203/02 ,  C08L2205/025 ,  C08L31/04

    摘要： A medical tube that contains a polymer composition that is generally flexible and biocompatible is provided. The polymer composition contains at least one ethylene vinyl acetate polymer and at least one viscoelastic additive. By selectively controlling specific aspects of the ethylene vinyl acetate polymer (e.g., vinyl acetate content, melt flow index, density, etc.), the viscoelastic additive, and the manner in which they are blended, the resulting composition can exhibit a reduced tendency to kink when formed into the medical tube.

    摘要翻译： 提供了包含通常柔性和生物相容性的聚合物组合物的医用管。 该聚合物组合物含有至少一种乙烯乙酸乙烯酯聚合物和至少一种粘弹性添加剂。 通过选择性地控制乙烯 - 乙酸乙烯酯聚合物的具体方面（例如乙酸乙烯酯含量，熔体流动指数，密度等），粘弹性添加剂以及它们混合的方式，所得组合物可以显示出降低 当形成医疗管时扭结。

    IMPLANTABLE DEVICE FOR SUSTAINED RELEASE OF A MACROMOLECULAR DRUG COMPOUND
    3.
    发明申请
    IMPLANTABLE DEVICE FOR SUSTAINED RELEASE OF A MACROMOLECULAR DRUG COMPOUND 审中-公开

    公开(公告)号：WO2019226519A1

    公开(公告)日：2019-11-28

    申请号：PCT/US2019/033063

    申请日：2019-05-20

    申请人： CELANESE EVA PERFORMANCE POLYMERS CORPORATION

    发明人： SCHNEIDER, Christian

    IPC分类号： A61F2/02 ,  A61K9/06 ,  A61L31/04 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16

    摘要： An implantable device for delivery of a macromolecular drug compound is provided. The device comprises a core having an outer surface and a membrane layer positioned adjacent to the outer surface of the core. The core comprises a core polymer matrix within which is dispersed a drug compound having a molecular weight of about 0.5 kDa or more, the polymer matrix containing a hydrophobic polymer. Further, the membrane layer comprises a membrane polymer matrix within which the macromolecular drug compound is optionally dispersed. The membrane polymer matrix contains a hydrophobic polymer in combination with a hydrophilic compound, and the weight ratio of the hydrophobic polymer to the hydrophilic compound within the membrane polymer matrix ranges from about 0.25 to about 200.

    IMPLANTABLE DEVICE FOR SUSTAINED RELEASE OF A MACROMOLECULAR DRUG COMPOUND
    4.
    发明申请
    IMPLANTABLE DEVICE FOR SUSTAINED RELEASE OF A MACROMOLECULAR DRUG COMPOUND 审中-公开

    公开(公告)号：WO2019226516A1

    公开(公告)日：2019-11-28

    申请号：PCT/US2019/033059

    申请日：2019-05-20

    申请人： CELANESE EVA PERFORMANCE POLYMERS CORPORATION

    发明人： SCHNEIDER, Christian

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/24 ,  A61K47/08

    摘要： An implantable device for delivery of a macromolecular drug compound is provided. The device comprises a core having an outer surface and a membrane layer positioned adjacent to the outer surface of the core. The core comprises a core polymer matrix within which is dispersed a drug compound having a molecular weight of about 0.5 kDa or more, the polymer matrix containing a hydrophobic polymer. Further, the membrane layer comprises a membrane polymer matrix within which the macromolecular drug compound is optionally dispersed. The concentration of the macromolecular drug compound in the core is greater than the concentration of the macromolecular drug compound in the membrane layer.