公开(公告)号：WO2008012290A3

公开(公告)日：2008-01-31

申请号：PCT/EP2007/057585

申请日：2007-07-23

Applicant: CHIESI FARMACEUTICI S.p.A. ,  AMARI, Gabriele ,  RIZZI, Andrea ,  PATACCHINI, Riccardo ,  CENACCHI, Valentina ,  VILLETTI, Gino ,  CATENA RUIZ, Juan Lorenzo ,  MASIP MASIP, Isabel

Inventor： AMARI, Gabriele ,  RIZZI, Andrea ,  PATACCHINI, Riccardo ,  CENACCHI, Valentina ,  VILLETTI, Gino ,  CATENA RUIZ, Juan Lorenzo ,  MASIP MASIP, Isabel

IPC: C07D453/02 ,  A61K45/06 ,  A61P11/00

Abstract: Quinuclidine derivative of the general formula (I) in the form of single enantiomers or mixtures thereof are useful in the manufacture of a medicament for the prevention and therapy of respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, cough and emphysema wherein: R 1 is selected from H, F, C1, Br, I and (C 1 -C 4 )- alkyl; R 2 is optionally substituted 2- or 3-thienyl, or substituted phenyl; R 3 is (CH 2 ) 1-4 -COR 4 or (CH 2 ) 1-4 -S(O) n R 4 , wherein R 4 is optionally substituted phenyl or optionally substituted 2- or 3-thienyl; n is 0, 1 or 2; X - is a pharmaceutically acceptable anion.

公开(公告)号：WO2008012290A2

公开(公告)日：2008-01-31

申请号：PCT/EP2007057585

申请日：2007-07-23

Applicant: CHIESI FARMA SPA ,  AMARI GABRIELE ,  RIZZI ANDREA ,  PATACCHINI RICCARDO ,  CENACCHI VALENTINA ,  VILLETTI GINO ,  CATENA RUIZ JUAN LORENZO ,  MASIP MASIP ISABEL

Inventor： AMARI GABRIELE ,  RIZZI ANDREA ,  PATACCHINI RICCARDO ,  CENACCHI VALENTINA ,  VILLETTI GINO ,  CATENA RUIZ JUAN LORENZO ,  MASIP MASIP ISABEL

IPC: C07D453/02 ,  A61K45/06 ,  A61P11/00

CPC classification number: C07D453/02

Abstract: Quinuclidine derivative of the general formula (I) in the form of single enantiomers or mixtures thereof are useful in the manufacture of a medicament for the prevention and therapy of respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, cough and emphysema wherein: R 1 is selected from H, F, C1, Br, I and (C 1 -C 4 )- alkyl; R 2 is optionally substituted 2- or 3-thienyl, or substituted phenyl; R 3 is (CH 2 ) 1-4 -COR 4 or (CH 2 ) 1-4 -S(O) n R 4 , wherein R 4 is optionally substituted phenyl or optionally substituted 2- or 3-thienyl; n is 0, 1 or 2; X - is a pharmaceutically acceptable anion.

Abstract translation: 单一对映异构体或其混合物形式的通式（I）的奎宁环衍生物可用于制备用于预防和治疗呼吸系统疾病如哮喘，慢性阻塞性肺疾病（COPD），慢性支气管炎，咳嗽 和肺气肿，其中：R 1选自H，F，C 1，Br，I和（C 1 -C 4 - ） - 烷基; R 2是任选取代的2-或3-噻吩基或取代的苯基; R 3是（CH 2）2 - （CH 2）2或 - （CH 2） 其中R 4是任选取代的苯基，其中R 4是任选取代的苯基 或任选取代的2-或3-噻吩基; n为0,1或2; X 是药学上可接受的阴离子。