公开(公告)号：WO2008012290A2

公开(公告)日：2008-01-31

申请号：PCT/EP2007057585

申请日：2007-07-23

Applicant: CHIESI FARMA SPA ,  AMARI GABRIELE ,  RIZZI ANDREA ,  PATACCHINI RICCARDO ,  CENACCHI VALENTINA ,  VILLETTI GINO ,  CATENA RUIZ JUAN LORENZO ,  MASIP MASIP ISABEL

Inventor： AMARI GABRIELE ,  RIZZI ANDREA ,  PATACCHINI RICCARDO ,  CENACCHI VALENTINA ,  VILLETTI GINO ,  CATENA RUIZ JUAN LORENZO ,  MASIP MASIP ISABEL

IPC: C07D453/02 ,  A61K45/06 ,  A61P11/00

CPC classification number: C07D453/02

Abstract: Quinuclidine derivative of the general formula (I) in the form of single enantiomers or mixtures thereof are useful in the manufacture of a medicament for the prevention and therapy of respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, cough and emphysema wherein: R 1 is selected from H, F, C1, Br, I and (C 1 -C 4 )- alkyl; R 2 is optionally substituted 2- or 3-thienyl, or substituted phenyl; R 3 is (CH 2 ) 1-4 -COR 4 or (CH 2 ) 1-4 -S(O) n R 4 , wherein R 4 is optionally substituted phenyl or optionally substituted 2- or 3-thienyl; n is 0, 1 or 2; X - is a pharmaceutically acceptable anion.

Abstract translation: 单一对映异构体或其混合物形式的通式（I）的奎宁环衍生物可用于制备用于预防和治疗呼吸系统疾病如哮喘，慢性阻塞性肺疾病（COPD），慢性支气管炎，咳嗽 和肺气肿，其中：R 1选自H，F，C 1，Br，I和（C 1 -C 4 - ） - 烷基; R 2是任选取代的2-或3-噻吩基或取代的苯基; R 3是（CH 2）2 - （CH 2）2或 - （CH 2） 其中R 4是任选取代的苯基，其中R 4是任选取代的苯基 或任选取代的2-或3-噻吩基; n为0,1或2; X 是药学上可接受的阴离子。

公开(公告)号：WO2006066924A2

公开(公告)日：2006-06-29

申请号：PCT/EP2005/013887

申请日：2005-12-22

Applicant: CHIESI FARMACEUTICI S.P.A. ,  PERETTO, Ilaria ,  SCARPITTA, Francesca ,  LA PORTA, Elena ,  RAVEGLIA, Luca ,  GIARDINA, Giuseppe, Arnaldo, Maria ,  IMBIMBO, Bruno, Pietro ,  RIZZI, Andrea ,  VILLETTI, Gino

Inventor： PERETTO, Ilaria ,  SCARPITTA, Francesca ,  LA PORTA, Elena ,  RAVEGLIA, Luca ,  GIARDINA, Giuseppe, Arnaldo, Maria ,  IMBIMBO, Bruno, Pietro ,  RIZZI, Andrea ,  VILLETTI, Gino

IPC: C07D401/04 ,  A61K31/454 ,  A61P11/00 ,  A61P1/00

CPC classification number: C07D401/14 ,  C07D401/04

Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, x, X, Y and B are as defined in the description for the treatment of muscarinic acetylcholine receptor mediated diseases, in particular M3 muscarinic receptor mediated diseases.

Abstract translation: 本发明涉及式（I）化合物，其中R 1，R 2，X，X，Y和B如描述中所述，用于治疗毒蕈碱性乙酰胆碱受体介导的疾病，特别是M3毒蕈碱受体介导的疾病。

公开(公告)号：WO1998003472A1

公开(公告)日：1998-01-29

申请号：PCT/EP1997003773

申请日：1997-07-15

Applicant: CHIESI FARMACEUTICI S.P.A. ,  CHIESI, Paolo ,  VENTURA, Paolo ,  DELCANALE, Maurizio ,  DE FANTI, Renato ,  ARMANI, Elisabetta ,  VILLETTI, Gino ,  PIETRA, Claudio

Inventor： CHIESI FARMACEUTICI S.P.A.

IPC: C07C237/06

CPC classification number: C07C237/06 ,  C07B2200/07 ,  C07C237/20 ,  C07C2602/08 ,  C07C2602/10

Abstract: The present invention relates to serinamide, glycinamide, alaninamide and phenylalaninamide derivatives of formula (I) wherein R, R', R1 and R2 are as defined in the disclosure. The compounds (I) are useful for the treatment of neurological diseases.

Abstract translation: 本发明涉及式（I）的丝氨酰胺，甘氨酰胺，丙氨酰胺和苯丙氨酰胺衍生物，其中R，R'，R 1和R 2如本公开内容所定义。 化合物（I）可用于治疗神经疾病。

公开(公告)号：WO2011151330A1

公开(公告)日：2011-12-08

申请号：PCT/EP2011/058956

申请日：2011-05-31

Applicant: CHIESI FARMACEUTICI S.P.A. ,  IMBIMBO, Bruno, Pietro ,  VILLETTI, Gino ,  POLI, Giorgio

Inventor： IMBIMBO, Bruno, Pietro ,  VILLETTI, Gino ,  POLI, Giorgio

IPC: A61K31/192 ,  A61P31/00

CPC classification number: A61K31/192

Abstract: The present invention relates to the therapeutic use of derivatives of l-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid for the prevention and/or treatment of prion diseases in animals and humans.

Abstract translation: 本发明涉及1-（2-氟联苯-4-基） - 环丙烷羧酸衍生物在动物和人类中预防和/或治疗朊病毒疾病的治疗用途。

公开(公告)号：WO2008012290A3

公开(公告)日：2008-01-31

申请号：PCT/EP2007/057585

申请日：2007-07-23

Applicant: CHIESI FARMACEUTICI S.p.A. ,  AMARI, Gabriele ,  RIZZI, Andrea ,  PATACCHINI, Riccardo ,  CENACCHI, Valentina ,  VILLETTI, Gino ,  CATENA RUIZ, Juan Lorenzo ,  MASIP MASIP, Isabel

Inventor： AMARI, Gabriele ,  RIZZI, Andrea ,  PATACCHINI, Riccardo ,  CENACCHI, Valentina ,  VILLETTI, Gino ,  CATENA RUIZ, Juan Lorenzo ,  MASIP MASIP, Isabel

IPC: C07D453/02 ,  A61K45/06 ,  A61P11/00

Abstract: Quinuclidine derivative of the general formula (I) in the form of single enantiomers or mixtures thereof are useful in the manufacture of a medicament for the prevention and therapy of respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, cough and emphysema wherein: R 1 is selected from H, F, C1, Br, I and (C 1 -C 4 )- alkyl; R 2 is optionally substituted 2- or 3-thienyl, or substituted phenyl; R 3 is (CH 2 ) 1-4 -COR 4 or (CH 2 ) 1-4 -S(O) n R 4 , wherein R 4 is optionally substituted phenyl or optionally substituted 2- or 3-thienyl; n is 0, 1 or 2; X - is a pharmaceutically acceptable anion.

公开(公告)号：WO2006066924A3

公开(公告)日：2006-08-31

申请号：PCT/EP2005013887

申请日：2005-12-22

Applicant: CHIESI FARMA SPA ,  PERETTO ILARIA ,  SCARPITTA FRANCESCA ,  LA PORTA ELENA ,  RAVEGLIA LUCA ,  GIARDINA GIUSEPPE ARNALDO MARI ,  IMBIMBO BRUNO PIETRO ,  RIZZI ANDREA ,  VILLETTI GINO

Inventor： PERETTO ILARIA ,  SCARPITTA FRANCESCA ,  LA PORTA ELENA ,  RAVEGLIA LUCA ,  GIARDINA GIUSEPPE ARNALDO MARI ,  IMBIMBO BRUNO PIETRO ,  RIZZI ANDREA ,  VILLETTI GINO

IPC: C07D401/04 ,  A61K31/454 ,  A61P1/00 ,  A61P11/00

CPC classification number: C07D401/14 ,  C07D401/04

Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, x, X, Y and B are as defined in the description for the treatment of muscarinic acetylcholine receptor mediated diseases, in particular M3 muscarinic receptor mediated diseases.

Abstract translation: 本发明涉及式（I）化合物，其中R 1，R 2，x，X，Y和B如在用于治疗毒蕈碱性乙酰胆碱受体介导的疾病，特别是M3毒蕈碱性受体介导的疾病的描述中所定义。

公开(公告)号：WO03053429A2

公开(公告)日：2003-07-03

申请号：PCT/EP0213839

申请日：2002-12-06

Applicant: CHIESI FARMA SPA ,  PIETRA CLAUDIO ,  VILLETTI GINO

Inventor： PIETRA CLAUDIO ,  VILLETTI GINO

IPC: A61K31/165 ,  A61K31/198 ,  A61P25/02 ,  A61P25/04

CPC classification number: A61K31/165

Abstract: The present invention relates to the use of 2-indanylamino derivatives for the treatment of chronic pain. In particular, the invention relates to the use of 2-(2-indanylamino)-acetamide for the treatment of neuropathic pain, i.e. the pain associated with postherpetic neuralgia, trigeminal neuralgia, diabetic neuropathy and nerve distruction by the human immunodeficiency virus (HIV).

Abstract translation: 本发明涉及2-茚满基氨基衍生物用于治疗慢性疼痛的用途。 特别地，本发明涉及2-（2,3-二氢化茚基氨基） - 乙酰胺用于治疗神经性疼痛的用途，即与带状疱疹后神经痛，三叉神经痛，糖尿病性神经病和人免疫缺陷病毒（HIV）的神经破坏相关的疼痛， 。

公开(公告)号：WO2012168226A1

公开(公告)日：2012-12-13

申请号：PCT/EP2012/060579

申请日：2012-06-05

Applicant: CHIESI FARMACEUTICI S.P.A. ,  ARMANI, Elisabetta ,  AMARI, Gabriele ,  CARZANIGA, Laura ,  CAPALDI, Carmelida ,  ESPOSITO, Oriana ,  VILLETTI, Gino ,  DE FANTI, Renato

Inventor： ARMANI, Elisabetta ,  AMARI, Gabriele ,  CARZANIGA, Laura ,  CAPALDI, Carmelida ,  ESPOSITO, Oriana ,  VILLETTI, Gino ,  DE FANTI, Renato

IPC: C07D213/89 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  A61K31/4436 ,  A61K31/4439 ,  A61P11/00 ,  A61P37/08 ,  A61P17/00

CPC classification number: A61K31/4425 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K31/635 ,  A61K45/06 ,  C07D213/30 ,  C07D213/89 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D498/04

Abstract: The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols of formula (I), methods of preparing such compounds, compositions containing them and therapeutic use thereof.

Abstract translation: 本发明涉及磷酸二酯酶4（PDE4）酶的抑制剂。 更具体地，本发明涉及作为式（I）的1-苯基-2-吡啶基烷基醇的衍生物的化合物，制备这些化合物的方法，含有它们的组合物及其治疗用途。

公开(公告)号：WO2009077068A1

公开(公告)日：2009-06-25

申请号：PCT/EP2008/010053

申请日：2008-11-27

Applicant: CHIESI FARMACEUTICI S.P.A. ,  AMARI, Gabriele ,  ARMANI, Elisabetta ,  VILLETTI, Gino

Inventor： AMARI, Gabriele ,  ARMANI, Elisabetta ,  VILLETTI, Gino

IPC: C07D213/30 ,  C07D213/89 ,  C07D405/06 ,  C07D405/14 ,  A61K31/443

CPC classification number: C07D213/30 ,  C07D213/89 ,  C07D405/06 ,  C07D405/14

Abstract: The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are new ester derivatives, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

Abstract translation: 本发明涉及磷酸二酯酶4（PDE4）酶的抑制剂。 更具体地说，本发明涉及作为新的酯衍生物的化合物，制备这些化合物的方法，含有它们的组合物及其治疗用途。

公开(公告)号：WO2007096076A2

公开(公告)日：2007-08-30

申请号：PCT/EP2007/001243

申请日：2007-02-13

Applicant: CHIESI FARMACEUTICI S.P.A. ,  OTTONELLO, Simone ,  MORETTO, NADIA ,  IMBIMBO, Bruno, Pietro ,  VILLETTI, Gino

Inventor： OTTONELLO, Simone ,  MORETTO, NADIA ,  IMBIMBO, Bruno, Pietro ,  VILLETTI, Gino

IPC: A61K39/00 ,  A61P25/28

CPC classification number: A61K39/0007 ,  A61K39/385 ,  A61K2039/505 ,  A61K2039/6068 ,  A61K2039/627 ,  C07K16/18

Abstract: The present invention provides a recombinant immunogenic obtained by tandem multimerization of a B-cell epitope bearing fragment of Aβ42, within the active loop site of a carrier (display site), preferably bacterial thioredoxin (Trx). Polypeptides bearing multiple copies of Aβ42 fragments, preferably with an interposed amino acid linker, were constructed and injected into mice in combination with an adjuvant. Elicited antibodies were found to selectively bind to fibrillar and/or oligomers Aβ within neuritic AD plaques.

Abstract translation: 本发明提供了通过在载体（展示位点）的活性环位点，优选细菌硫氧还蛋白（Trx）中串联多聚Aβ42的具有B细胞表位的抗原决定基片段而获得的重组免疫原性。 带有多个Aβ42片段拷贝的多肽，优选具有插入的氨基酸接头，被构建并与佐剂一起注射到小鼠体内。 发现诱发的抗体选择性结合神经炎AD斑块内的原纤维和/或寡聚体Aβ。