公开(公告)号：WO2010060216A1

公开(公告)日：2010-06-03

申请号：PCT/CA2009/001728

申请日：2009-11-26

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA ,  NATIONAL CHUNG CHENG UNIVERSITY ,  HUANG, Ping-Ji ,  CHAU, Lai-Kwan ,  TAY, Li-Lin ,  TANHA, Jamshid

Inventor： HUANG, Ping-Ji ,  CHAU, Lai-Kwan ,  TAY, Li-Lin ,  TANHA, Jamshid

IPC: C07K17/00 ,  C07K16/00 ,  C07K16/12 ,  C07K17/14 ,  G01N21/65 ,  G01N33/569

CPC classification number: C07K17/14 ,  C07K16/00 ,  C07K16/1271 ,  C07K2317/21 ,  C07K2317/569 ,  G01N21/658 ,  G01N33/54313 ,  G01N33/569 ,  G01N2333/205 ,  G01N2333/245 ,  G01N2333/25 ,  G01N2333/255 ,  G01N2333/31 ,  G01N2333/33 ,  Y10T428/2991

Abstract: A nanoaggregate embedded bead is formed from an inner core formed of comprising metallic nanoparticles and Raman active reporter molecules, an outer shell, and single-domain antibodies to target the bead to a specific target. The nanoaggregate embedded bead may be used in methods to detect analytes or pathogens in biological or environmental samples using Raman spectroscopy.

Abstract translation: 由包含金属纳米颗粒和拉曼活性报道分子，外壳和单结构域抗体形成的内核形成纳米聚集体包埋珠，以将珠靶向特定靶。 纳米聚集体嵌入珠可用于使用拉曼光谱法检测生物或环境样品中的分析物或病原体的方法。