公开(公告)号：WO2012112951A1

公开(公告)日：2012-08-23

申请号：PCT/US2012/025736

申请日：2012-02-17

Applicant: CHD BIOSCIENCE, INC. ,  NEAS, Edwin, D. ,  SKINNER, John, D.

Inventor： NEAS, Edwin, D. ,  SKINNER, John, D.

IPC: A61K31/19 ,  C07C409/24

CPC classification number: A61K31/22 ,  A01N37/16 ,  A61K31/327 ,  A61K2300/00 ,  A01N37/42 ,  A01N2300/00

Abstract: The present invention provides compositions comprising peroxy α-ketocarboxylic acid and methods for using the same. In some particular embodiments, compositions of the invention also include α-ketoesters.

Abstract translation: 本发明提供了包含过氧化α-酮羧酸的组合物及其使用方法。 在一些具体实施方案中，本发明的组合物还包括α-酮酯。

公开(公告)号：WO2014063107A2

公开(公告)日：2014-04-24

申请号：PCT/US2013065769

申请日：2013-10-18

Applicant: CHD BIOSCIENCE INC ,  NEAS EDWIN D ,  HANDLEY MICHAEL K ,  MARCHITTO KEVIN S ,  FLOCK STEPHEN T ,  HENRY CHARLES

Inventor： NEAS EDWIN D ,  HANDLEY MICHAEL K ,  MARCHITTO KEVIN S ,  FLOCK STEPHEN T ,  HENRY CHARLES

IPC: A61L26/00 ,  A61K31/19 ,  A61K31/22 ,  A61K31/327 ,  A61K33/40 ,  A61K45/06

CPC classification number: A01N59/00 ,  A01N25/02 ,  A01N37/16 ,  A01N37/36 ,  A01N37/42 ,  A61K31/22 ,  A61K31/327 ,  A61K33/40 ,  A61K45/06 ,  A01N2300/00 ,  A61K2300/00

Abstract: Methods have been developed for incorporation of peracid compounds and related compositions into a non-aqueous medium. The peracid incorporated into the non-aqueous medium is stable and keeps its chemical and antimicrobial activity for extended durations. The non-aqueous medium may be removed just prior to or during application of the peracid.

Abstract translation: 已经开发了用于将过酸化合物和相关组合物掺入非水介质中的方法。 掺入非水介质中的过酸是稳定的并且在延长的持续时间内保持其化学和抗微生物活性。 非水介质可以在施用过酸之前或期间被去除。

公开(公告)号：WO2014063115A1

公开(公告)日：2014-04-24

申请号：PCT/US2013/065782

申请日：2013-10-18

Applicant: CHD BIOSCIENCE, INC. ,  NEAS, Edwin D. ,  SKINNER, John D.

Inventor： NEAS, Edwin D. ,  SKINNER, John D.

IPC: A01N37/02 ,  A01N37/16 ,  C07C409/24

CPC classification number: A01N59/00 ,  A01N25/02 ,  A01N37/16 ,  A01N37/36 ,  A01N37/42 ,  A61K31/22 ,  A61K31/327 ,  A61K33/40 ,  A61K45/06 ,  A01N2300/00 ,  A61K2300/00

Abstract: The present invention provides methods for producing a non α-keto peracid that has lower toxicity and lower corrosivity. The present embodiments also provide methods and compositions for reducing microbes on a surface, methods and compositions for preventing and reducing infectious vegetative bacteria on a substrate, and methods and compositions for treating a wound. In particular, compositions of the invention provide for a mixture of an α-keto peracid and a non α-keto peracid that works synergistically to reduce microbes on a surface, to prevent vegetative bacteria on a surface and to heal a wound in animals or humans.

Abstract translation: 本发明提供了生产具有较低毒性和较低腐蚀性的非α-酮过酸的方法。 本实施方案还提供了用于减少表面上的微生物的方法和组合物，用于预防和减少基底上感染性营养细菌的方法和组合物，以及用于治疗伤口的方法和组合物。 特别地，本发明的组合物提供α-酮过酸和非α-酮过酸的混合物，其协同作用以减少表面上的微生物，以防止表面上的营养细菌并愈合动物或人类的伤口 。

公开(公告)号：WO2014063107A3

公开(公告)日：2014-04-24

申请号：PCT/US2013/065769

申请日：2013-10-18

Applicant: CHD BIOSCIENCE, INC. ,  NEAS, Edwin D. ,  HANDLEY, Michael K. ,  MARCHITTO, Kevin S. ,  FLOCK, Stephen, T. ,  HENRY, Charles

Inventor： NEAS, Edwin D. ,  HANDLEY, Michael K. ,  MARCHITTO, Kevin S. ,  FLOCK, Stephen, T. ,  HENRY, Charles

IPC: A61K31/327

Abstract: Methods have been developed for incorporation of peracid compounds and related compositions into a non-aqueous medium. The peracid incorporated into the non-aqueous medium is stable and keeps its chemical and antimicrobial activity for extended durations. The non-aqueous medium may be removed just prior to or during application of the peracid.

公开(公告)号：WO2014028633A1

公开(公告)日：2014-02-20

申请号：PCT/US2013/054968

申请日：2013-08-14

Applicant: CHD BIOSCIENCE, INC. ,  NEAS, Edwin D. ,  HANDLEY, Michael K. ,  MARCHITTO, Kevin S. ,  FLOCK, Stephen, T.

Inventor： NEAS, Edwin D. ,  HANDLEY, Michael K. ,  MARCHITTO, Kevin S. ,  FLOCK, Stephen, T.

IPC: A61M37/00 ,  A61P31/04 ,  A61P17/02

CPC classification number: A61K31/185 ,  A61F13/00063 ,  A61K31/00 ,  A61K31/19 ,  A61K31/327 ,  A61L15/26 ,  A61L15/46 ,  A61L2300/21 ,  A61L2300/212 ,  A61L2300/404 ,  A61L2300/62 ,  A61M35/00 ,  F04C2270/0421 ,  C08L75/04 ,  A61K2300/00

Abstract: Methods have been developed for incorporation of a peracid compound into or on wound application matrices, such as bandages or dressings, and other matrices which will favorably impact wound healing and help eliminate microbial infection. The peracid compound comprises a base compound that is metabolically pertinent to wound healing, the oxidized form of the base compound (a peracid), and an appropriate oxidizer, such as hydrogen peroxide. In addition, other excipients with wound healing potential, such as esters of the base compound, may be added to the peracid compound. The combination peracid-wound application matrices can be used to disinfect and heal various wound types with designed time release of the peracid compound.

Abstract translation: 已经开发了用于将过酸化合物掺入伤口施用基质如绷带或敷料中的其它基质和有利地影响伤口愈合并帮助消除微生物感染的其它基质的方法。 过酸化合物包括与伤口愈合代谢相关的碱性化合物，碱化合物（过酸）的氧化形式和适当的氧化剂如过氧化氢。 此外，可以向过酸化合物中加入具有伤口愈合电位的其它赋形剂，例如碱性化合物的酯。 组合过酸伤口应用基质可用于消毒和治疗各种伤口类型，同时设计过酸化合物的释放时间。