公开(公告)号：WO2007055598A1

公开(公告)日：2007-05-18

申请号：PCT/NZ2006/000288

申请日：2006-11-09

Applicant: PROTEMIX CORPORATION LIMITED ,  COOPER, Garth, James, Smith ,  PHILLIPS, Anthony, Ronald, John ,  CHEN, Nancy, Xiuyin ,  GONG, Deming ,  JULLIG, Maria ,  HICKEY, Anthony, John, Rodney ,  GLYNN-JONES, Sarah

Inventor： COOPER, Garth, James, Smith ,  PHILLIPS, Anthony, Ronald, John ,  CHEN, Nancy, Xiuyin ,  GONG, Deming ,  JULLIG, Maria ,  HICKEY, Anthony, John, Rodney ,  GLYNN-JONES, Sarah

IPC: A61K31/32 ,  A61P1/16

CPC classification number: A61K31/132 ,  A61K31/195 ,  A61K31/225 ,  A61K31/32 ,  A61K31/325 ,  A61K31/4375 ,  A61K33/24

Abstract: Treatment of mitochondrial related conditions in mammals with antagonists or chelating agents of copper (II), preferably tetramines or penicillamines. These agents affect TGF-beta, Smad 4, collagen IV, cytochrome C oxidase and erectile dysfunction.

Abstract translation: 用铜（II），优选四胺或青霉胺的拮抗剂或螯合剂处理哺乳动物中的线粒体相关病症。 这些药物影响TGF-β，Smad4，胶原蛋白IV，细胞色素C氧化酶和勃起功能障碍。