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    METAL COMPLEXES HAVING AN ANTINEOPLASTIC ACTION, AND MEDICAMENTS CONTAINING THESE COMPLEXES
    3.
    发明申请
    METAL COMPLEXES HAVING AN ANTINEOPLASTIC ACTION, AND MEDICAMENTS CONTAINING THESE COMPLEXES 审中-公开
    具有抗肿瘤作用的金属复合物，以及含有这些复合物的药物

    公开(公告)号：WO1990006749A1

    公开(公告)日：1990-06-28

    申请号：PCT/EP1981000155

    申请日：1981-10-01

    Applicant: KELLER, Heimo, J. ,  KEPPLER, Bernhard ,  KRÜGER, Uwe ,  LINDER, Rudolf

    IPC: A61K31/28

    CPC classification number: A61K9/146 ,  A61K31/28 ,  A61K31/32 ,  C07C49/92

    Abstract: Complexes of the general formula [R1(CH2)mC(O)CR?3C(O)R2]¿2+nMX2-n, wherein M denotes tin, titanium, zirconium or hafnium, R1 denotes hydrogen or a phenyl radical, it being possible for the phenyl radical to be monosubstituted or polysubstituted by fluorine, chlorine, bromine, nitro, C¿1?-C4-alkyl, C1-C4-alkoxy or trifluoromethyl, R?2¿ denotes methyl or R1, with the exception of hydrogen, R3 denotes hydrogen or chlorine, X denotes fluorine, chlorine or bromine, but not fluorine if M denotes zirconium or hafnium, m denotes the number 1 or 0, or, if R1 denotes hydrogen, the number 1 and n denotes the number 0, or, if M denotes zirconium or hafnium, the number 1 or 0, exhibit a cytostatic activity which is comparable to that of cisplatin and are less toxic than cisplatin. They are suitable for the production of medicaments having an antineoplastic action.

    TREATING RENAL DISEASE, BURNS, WOUNDS AND SPINAL CORD INJURY WITH SELECTIVE ANDROGEN RECEPTOR MODULATORS
    6.
    发明申请
    TREATING RENAL DISEASE, BURNS, WOUNDS AND SPINAL CORD INJURY WITH SELECTIVE ANDROGEN RECEPTOR MODULATORS 审中-公开
    选择性雄激素受体调节剂治疗肾脏疾病，烧伤，创伤和脊髓损伤

    公开(公告)号：WO2007027582A2

    公开(公告)日：2007-03-08

    申请号：PCT/US2006/033490

    申请日：2006-08-28

    Applicant: GTX, INC. ,  DALTON, James, T. ,  MILLER, Duane, D.

    Inventor： DALTON, James, T. ,  MILLER, Duane, D.

    IPC: A61K31/675 ,  A61K31/555 ,  A61K31/4709 ,  A61K31/405 ,  A61K31/4704 ,  A61K31/32 ,  A61K31/277 ,  A61K31/165

    CPC classification number: A61K31/165 ,  A61K31/277 ,  A61K31/32 ,  A61K31/405 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/555 ,  A61K31/675

    Abstract: This invention provides: 1) a method of treating a subject suffering from, or predisposed to a kidney disease or disorder; 2) a method of treating a subject suffering from a wound, or reducing the incidence of, or mitigating the severity of a wound in a subject; 3) a method of treating a subject suffering from a burn, or reducing the incidence of, or mitigating the severity of a burn in a subject, comprising the step of administering to said subject a selective androgen receptor modulator (SARM) compound; 4) a method of treating a subject suffering from a spinal cord injury, by administering to the subject a selective androgen receptor modulator (SARM) and/or an analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, prodrug, polymorph, impurity or crystal of said SARM compound, or any combination thereof.

    Abstract translation: 本发明提供：1）治疗罹患肾脏疾病或病症或易患肾病的个体的方法; 2）治疗患有伤口的受试者，或降低受试者的伤口发病率或减轻其严重程度的方法; 3）治疗患有烧伤的受试者或降低受试者烧伤发生率或减轻其严重程度的方法，包括给所述受试者施用选择性雄激素受体调节剂（SARM）化合物的步骤; 4）通过向受试者施用选择性雄激素受体调节剂（SARM）和/或其类似物，衍生物，异构体，代谢物，药学上可接受的盐，药物产品，水合物，N 所述SARM化合物的前体药物，多晶型物，杂质或晶体，或其任何组合。

    COMPOSITION COMBINATIONS AND METHODS FOR TREATING, PREVENTING, REVERSING AND INHIBITING PAIN
    7.
    发明申请
    COMPOSITION COMBINATIONS AND METHODS FOR TREATING, PREVENTING, REVERSING AND INHIBITING PAIN 审中-公开
    用于治疗，预防，反转和抑制疼痛的组合物组合和方法

    公开(公告)号：WO2005060437A2

    公开(公告)日：2005-07-07

    申请号：PCT/US2004/036187

    申请日：2004-10-31

    Applicant: METAPHORE PHARMACEUTICALS, INC. ,  SALVEMINI, Daniela

    Inventor： SALVEMINI, Daniela

    CPC classification number: A61K45/06 ,  A61K31/28 ,  A61K31/295 ,  A61K31/32 ,  A61K38/42

    Abstract: The invention provides a combination of compositions for treating, preventing, reversing or inhibiting pain, wherein at least one composition comprises a nitration inhibitor. Further provided is a method wherein the nitration inhibitor is selected from the group consisting of a SO generating system inhibitor, SO scavenger, NOS inhibitor, NO generating system inhibitor, NO scavenger, peroxynitrite generating system inhibitor, peroxynitrite scavenger, and any combination thereof. Preferably, the nitration inhibitor is combined with a pain inhibitor. The pain inhibitor is still more preferably an opioid.

    Abstract translation: 本发明提供了用于治疗，预防，逆转或抑制疼痛的组合物的组合，其中至少一种组合物包含硝化抑制剂。 还提供了一种方法，其中硝化抑制剂选自SO生成系统抑制剂，SO清除剂，NOS抑制剂，NO产生体系抑制剂，NO清除剂，过氧亚硝酸盐产生体系抑制剂，过氧亚硝酸盐清除剂及其任何组合。 优选地，将硝化抑制剂与止痛剂组合。 疼痛抑制剂更优选为阿片样物质。

    ORGANOTIN(IV) COMPLEXES WITH N-ACETYLCYSTEINE POSSESSING ANTITUMORAL ACTIVITY, PROCESS FOR THEIR PRODUCTION AND THEIR USE
    9.
    发明申请
    ORGANOTIN(IV) COMPLEXES WITH N-ACETYLCYSTEINE POSSESSING ANTITUMORAL ACTIVITY, PROCESS FOR THEIR PRODUCTION AND THEIR USE 审中-公开
    组氨酸（IV）与N-乙酰胆碱酯酶抗肿瘤活性的复合物，其生产方法及其使用

    公开(公告)号：WO2010015590A1

    公开(公告)日：2010-02-11

    申请号：PCT/EP2009/060006

    申请日：2009-08-03

    Applicant: UNIVERSITA' DEGLI STUDI DI PALERMO ,  PELLERITO, Claudia ,  PRINZIVALLI, Cristina ,  PELLERITO, Ornella ,  GIULIANO, Michela

    Inventor： PELLERITO, Claudia ,  PRINZIVALLI, Cristina ,  PELLERITO, Ornella ,  GIULIANO, Michela

    IPC: A61K31/32 ,  C07F7/22 ,  A61P35/00

    CPC classification number: A61K31/32 ,  C07F7/2276

    Abstract: Organotin(IV) compounds with N-acetylcysteine having the general formula (1 ) o (2): wherein: R 1 , R 2 and R 3 are each independently selected from the group consisting of : H, an alkyl, alkoxyl, alkenyl or alkynyl group with up to 12 carbon atoms, an isocyclic or heterocyclic aromatic or aralkyl group with up to 12 carbon atoms, and they are preferably chosen from methyl, ethyl, butyl or phenyl, are synthetized by simple procedures from commercial products, and are active as anticancer agents. In particular, the Bu 2 Sn-N-acetylcysteinate derivative was found to have a potent and selective anticancer activity in vitro against several cancer cell lines.

    Abstract translation: 具有通式（1）o（2）的N-乙酰半胱氨酸的有机锡（IV）化合物：其中：R1，R2和R3各自独立地选自：H，烷基，烷氧基，烯基或炔基与 最多12个碳原子，具有至多12个碳原子的杂环或杂环芳族或芳烷基，它们优选选自甲基，乙基，丁基或苯基，通过商业产品的简单方法合成，并且作为抗癌剂是有活性的 。 特别地，发现Bu2Sn-N-乙酰半胱氨酸衍生物在体外对几种癌细胞系具有有效和选择性的抗癌活性。

    A METHOD OF TREATMENT AND PROPHYLAXIS OF EVENTS, CONDITIONS AND DISEASES OF THE SYSTEMIC VASCULATURE AN IMMUNE FUNCTION TO DECREASE CARDIOVASCULAR RISK AND PATHOGENIC INFECTION
    10.
    发明申请
    A METHOD OF TREATMENT AND PROPHYLAXIS OF EVENTS, CONDITIONS AND DISEASES OF THE SYSTEMIC VASCULATURE AN IMMUNE FUNCTION TO DECREASE CARDIOVASCULAR RISK AND PATHOGENIC INFECTION 审中-公开
    一种治疗和预防系统性血管活性，疾病和疾病的方法，免疫功能降低心血管风险和致病性感染

    公开(公告)号：WO2007140525A1

    公开(公告)日：2007-12-13

    申请号：PCT/AU2007/000788

    申请日：2007-06-05

    Applicant: HOENIG, Michel

    Inventor： HOENIG, Michel

    IPC: A61K33/00 ,  A61K33/32 ,  A61P9/00 ,  A61P31/00

    CPC classification number: A61K33/32 ,  A61K31/28 ,  A61K31/32 ,  A61K33/24

    Abstract: The present invention relates generally to the treatment and prophylaxis of events, conditions and diseases of the systemic vasculature and treatment and prophylaxis of infection by pathogenic agents. Agents are contemplated which enhance levels of stem cells and/or facilitate the angiogenic or vasculogenic capability of stem cells or their precursors or early committed cells of a particular cell lineage or to mobilize stem cells to thereby promote repair and maintenance of elements and components of the systemic vasculature. A method is also provided to activate hypoxic gene programming in target tissues to induce angiogenesis and recruit progenitor cells to that site. Still further, a method to facilitate enhancement of immune function is also provided. Agents and pharmaceutical compositions including functional foods and specialized drug delivery devices useful in the treatment and prophylaxis of events, conditions and disease of the systemic vasculature and to enhance the immune system are contemplated.

    Abstract translation: 本发明一般涉及系统性脉管系统的事件，病症和疾病的治疗和预防以及病原体感染的治疗和预防。 涵盖了提高干细胞水平和/或促进干细胞或其前体或特定细胞系的早期致细胞的血管生成或血管生成能力或者调动干细胞，从而促进干细胞的元件和组分的修复和维持的试剂 系统性脉管系统 还提供了一种方法来激活靶组织中的缺氧基因编程以诱导血管发生并将祖细胞募集到该位点。 此外，还提供了促进免疫功能增强的方法。 考虑了可用于治疗和预防系统性脉管系统的事件，病症和疾病以及增强免疫系统的功能性食品和专门药物递送装置的药剂和药物组合物。

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