公开(公告)号：WO2013059559A2

公开(公告)日：2013-04-25

申请号：PCT/US2012060971

申请日：2012-10-19

申请人： GLAXOSMITHKLINE LLC ,  BANKA ANNA LINDSEY ,  BOTYANSZKI JANOS ,  BURROUGHS ERIC GREGORY ,  CATALANO JOHN GEORGE ,  CHERN WENDY HUANG ,  DICKSON HAMILTON D ,  GARTLAND MARGARET J ,  HAMATAKE ROBERT ,  HOFLAND HANS ,  KEICHER JESSE DANIEL ,  MOORE CHRISTOPHER BROOKS ,  SHOTWELL JOHN BRADFORD ,  TALLANT MATTHEW DAVID ,  THERRIEN JEAN-PHILIPPE ,  YOU SHIHYUN

发明人： BANKA ANNA LINDSEY ,  BOTYANSZKI JANOS ,  BURROUGHS ERIC GREGORY ,  CATALANO JOHN GEORGE ,  CHERN WENDY HUANG ,  DICKSON HAMILTON D ,  GARTLAND MARGARET J ,  HAMATAKE ROBERT ,  HOFLAND HANS ,  KEICHER JESSE DANIEL ,  MOORE CHRISTOPHER BROOKS ,  SHOTWELL JOHN BRADFORD ,  TALLANT MATTHEW DAVID ,  THERRIEN JEAN-PHILIPPE ,  YOU SHIHYUN

IPC分类号： C07D471/14

CPC分类号： C07D471/14 ,  C07D471/04 ,  C07D491/048 ,  C07D498/04 ,  C07D498/14 ,  C07D513/04

摘要： Provided are certain compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections.

摘要翻译： 提供某些化合物及其药学上可接受的盐，其药物组合物，其制备方法及其用于治疗病毒感染的用途。

公开(公告)号：WO2011009023A1

公开(公告)日：2011-01-20

申请号：PCT/US2010/042225

申请日：2010-07-16

申请人： STIEFEL LABORATORIES, INC. ,  GE, Xue ,  WONG, Hansen ,  CHERN, Wendy, Huang ,  HOFLAND, Hans ,  BISHOP, Michael, J. ,  CAI, Frank ,  COLBORN, Alan

发明人： GE, Xue ,  WONG, Hansen ,  CHERN, Wendy, Huang ,  HOFLAND, Hans ,  BISHOP, Michael, J. ,  CAI, Frank ,  COLBORN, Alan

IPC分类号： A01N43/06 ,  A01N43/12 ,  A61K31/38

CPC分类号： C07D409/14 ,  A61K9/0014 ,  A61K31/05 ,  A61K31/327 ,  A61K31/38 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/593 ,  A61K45/06 ,  C07D409/06 ,  A61K2300/00

摘要： The presently described subject matter relates to new derivatives of tazarotene that also exhibit retinoid activity, pharmaceutical compositions comprising the derivatives, method of treating skin disorders with the pharmaceutical compositions, and process of making the derivatives.

摘要翻译： 目前描述的主题涉及还显示类视黄醇活性的他扎罗汀的新衍生物，包含衍生物的药物组合物，用该药物组合物治疗皮肤病症的方法，以及制备衍生物的方法。

公开(公告)号：WO2013059559A3

公开(公告)日：2013-04-25

申请号：PCT/US2012/060971

申请日：2012-10-19

申请人： GLAXOSMITHKLINE LLC ,  BANKA, Anna, Lindsey ,  BOTYANSZKI, Janos ,  BURROUGHS, Eric, Gregory ,  CATALANO, John, George ,  CHERN, Wendy, Huang ,  DICKSON, Hamilton, D. ,  GARTLAND, Margaret, J. ,  HAMATAKE, Robert ,  HOFLAND, Hans ,  KEICHER, Jesse, Daniel ,  MOORE, Christopher, Brooks ,  SHOTWELL, John, Bradford ,  TALLANT, Matthew, David ,  THERRIEN, Jean-Philippe ,  YOU, Shihyun

发明人： BANKA, Anna, Lindsey ,  BOTYANSZKI, Janos ,  BURROUGHS, Eric, Gregory ,  CATALANO, John, George ,  CHERN, Wendy, Huang ,  DICKSON, Hamilton, D. ,  GARTLAND, Margaret, J. ,  HAMATAKE, Robert ,  HOFLAND, Hans ,  KEICHER, Jesse, Daniel ,  MOORE, Christopher, Brooks ,  SHOTWELL, John, Bradford ,  TALLANT, Matthew, David ,  THERRIEN, Jean-Philippe ,  YOU, Shihyun

IPC分类号： A61K31/437

摘要： Provided are certain compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections. The present invention relates to compounds that act as enhancers of the host's immune response. The compounds are believed to up-regulate expression and/or activity of one or more of these proteins, thereby leading to better viral defense and/or treatment.