公开(公告)号：WO2012037108A1

公开(公告)日：2012-03-22

申请号：PCT/US2011/051372

申请日：2011-09-13

申请人： GLAXOSMITHKLINE LLC ,  BANKA, Anna, Lindsey ,  BOTYANSZKI, Janos ,  DICKERSON, Scott, Howard ,  DUAN, Maosheng ,  LEIVERS, Martin, Robert ,  MCFADYEN, Robert, Blount ,  MOORE, Christopher, Brooks ,  REDMAN, Aniko, Maria ,  SHOTWELL, John, Bradford ,  TAI, Vincent, W.-F. ,  TALLANT, Matthew, David ,  XUE, Jianjun

发明人： BANKA, Anna, Lindsey ,  BOTYANSZKI, Janos ,  DICKERSON, Scott, Howard ,  DUAN, Maosheng ,  LEIVERS, Martin, Robert ,  MCFADYEN, Robert, Blount ,  MOORE, Christopher, Brooks ,  REDMAN, Aniko, Maria ,  SHOTWELL, John, Bradford ,  TAI, Vincent, W.-F. ,  TALLANT, Matthew, David ,  XUE, Jianjun

IPC分类号： A01N43/42 ,  A61K31/47

CPC分类号： C07D215/38 ,  A61K31/47 ,  A61K31/7056 ,  A61K38/21 ,  A61K45/06 ,  C07D215/50 ,  C07D291/08 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D471/18 ,  C07D491/10 ,  A61K2300/00

摘要： Provided are compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).

摘要翻译： 提供式（I）和式（II）的化合物及其药学上可接受的盐，其药物组合物，它们的制备方法及其用于治疗由病毒如黄病毒科家族成员介导的病毒感染的用途，例如丙型肝炎病毒 （HCV）。

公开(公告)号：WO2013059559A2

公开(公告)日：2013-04-25

申请号：PCT/US2012060971

申请日：2012-10-19

申请人： GLAXOSMITHKLINE LLC ,  BANKA ANNA LINDSEY ,  BOTYANSZKI JANOS ,  BURROUGHS ERIC GREGORY ,  CATALANO JOHN GEORGE ,  CHERN WENDY HUANG ,  DICKSON HAMILTON D ,  GARTLAND MARGARET J ,  HAMATAKE ROBERT ,  HOFLAND HANS ,  KEICHER JESSE DANIEL ,  MOORE CHRISTOPHER BROOKS ,  SHOTWELL JOHN BRADFORD ,  TALLANT MATTHEW DAVID ,  THERRIEN JEAN-PHILIPPE ,  YOU SHIHYUN

发明人： BANKA ANNA LINDSEY ,  BOTYANSZKI JANOS ,  BURROUGHS ERIC GREGORY ,  CATALANO JOHN GEORGE ,  CHERN WENDY HUANG ,  DICKSON HAMILTON D ,  GARTLAND MARGARET J ,  HAMATAKE ROBERT ,  HOFLAND HANS ,  KEICHER JESSE DANIEL ,  MOORE CHRISTOPHER BROOKS ,  SHOTWELL JOHN BRADFORD ,  TALLANT MATTHEW DAVID ,  THERRIEN JEAN-PHILIPPE ,  YOU SHIHYUN

IPC分类号： C07D471/14

CPC分类号： C07D471/14 ,  C07D471/04 ,  C07D491/048 ,  C07D498/04 ,  C07D498/14 ,  C07D513/04

摘要： Provided are certain compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections.

摘要翻译： 提供某些化合物及其药学上可接受的盐，其药物组合物，其制备方法及其用于治疗病毒感染的用途。

公开(公告)号：WO2018039131A1

公开(公告)日：2018-03-01

申请号：PCT/US2017/047821

申请日：2017-08-21

申请人： PROTIVA BIOTHERAPEUTICS, INC. ,  MOORE, Christopher Brooks ,  PARK, Jang-June

发明人： MOORE, Christopher Brooks ,  PARK, Jang-June

IPC分类号： A61K39/00

摘要： Certain embodiments of the invention provide a method for treating a Hepatitis B virus infection and/or ameliorating one or more symptoms associated with a Hepatitis B virus infection in a mammal, the method comprising the step of administering to the mammal a therapeutically effective amount of an anti-PD-1 antibody, or fragment thereof.

摘要翻译： 本发明的某些实施方案提供了用于治疗哺乳动物的乙型肝炎病毒感染和/或改善与乙型肝炎病毒感染相关的一种或多种症状的方法，所述方法包括给予 哺乳动物治疗有效量的抗PD-1抗体或其片段。

公开(公告)号：WO2013059559A3

公开(公告)日：2013-04-25

申请号：PCT/US2012/060971

申请日：2012-10-19

申请人： GLAXOSMITHKLINE LLC ,  BANKA, Anna, Lindsey ,  BOTYANSZKI, Janos ,  BURROUGHS, Eric, Gregory ,  CATALANO, John, George ,  CHERN, Wendy, Huang ,  DICKSON, Hamilton, D. ,  GARTLAND, Margaret, J. ,  HAMATAKE, Robert ,  HOFLAND, Hans ,  KEICHER, Jesse, Daniel ,  MOORE, Christopher, Brooks ,  SHOTWELL, John, Bradford ,  TALLANT, Matthew, David ,  THERRIEN, Jean-Philippe ,  YOU, Shihyun

发明人： BANKA, Anna, Lindsey ,  BOTYANSZKI, Janos ,  BURROUGHS, Eric, Gregory ,  CATALANO, John, George ,  CHERN, Wendy, Huang ,  DICKSON, Hamilton, D. ,  GARTLAND, Margaret, J. ,  HAMATAKE, Robert ,  HOFLAND, Hans ,  KEICHER, Jesse, Daniel ,  MOORE, Christopher, Brooks ,  SHOTWELL, John, Bradford ,  TALLANT, Matthew, David ,  THERRIEN, Jean-Philippe ,  YOU, Shihyun

IPC分类号： A61K31/437

摘要： Provided are certain compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections. The present invention relates to compounds that act as enhancers of the host's immune response. The compounds are believed to up-regulate expression and/or activity of one or more of these proteins, thereby leading to better viral defense and/or treatment.