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    ALEXANDRITE LASER SYSTEM FOR TREATMENT OF DERMATOLOGICAL SPECIMENS
    3.
    发明申请
    ALEXANDRITE LASER SYSTEM FOR TREATMENT OF DERMATOLOGICAL SPECIMENS 审中-公开
    用于治疗皮肤样本的ALEXANDRITE激光系统

    公开(公告)号：WO1997037602A2

    公开(公告)日：1997-10-16

    申请号：PCT/US1997005560

    申请日：1997-04-04

    Applicant: CYNOSURE, INC. ,  FURUMOTO, Horace, W. ,  CHO, George ,  McDANIEL, David, H. ,  KOSCHMANN, Eric ,  RIZZO, Antonio, G.

    Inventor： CYNOSURE, INC.

    IPC: A61B17/41

    CPC classification number: H01S3/092 ,  A61B18/203 ,  A61B2017/00172 ,  A61B2017/22085 ,  A61B2018/00452 ,  A61B2018/00476 ,  H01S3/08072 ,  H01S3/1633 ,  H01S2301/08

    Abstract: A long pulse alexandrite laser for treating dermatological specimens is disclosed. The use of alexandrite allows operation in the near-infrared, specifically in a 50 nm range surrounding 755. Infrared in this range allows good penetration while still achieving an acceptable ratio of hemoglobin to melanin absorption. In operation, the laser generates pulses having a durations between 5 and 100 msec and fluences between 10 and 50 J/cm . A light delivery system is provided that transmits the laser light output pulse to dermatological targets of a patient. The invention is also directed to a hair removal system. Here, it is desirable to use an index-matching application on the skin sections to be treated, and a visual indicator is thermo- or photo-responsive or otherwise responsive to the laser light pulse to generate a visible change. This provides the operator with a record of those parts of the skin that have already been treated. Finally, the invention is directed to a combined sclerotherapy and light treatment method and kit for unwanted veins. Substantially increased success, in the range of 90-100 % has been achieved by implementing a dwell time of between 12 hours and 6 months between the light-based therapy and the sclerotherapy. Preferably, the light-based therapy is performed before the sclerotherapy. Success can be achieved by performing the sclerotherapy followed by the light-based therapy after the dwell time, however.

    Abstract translation: 公开了用于治疗皮肤病学标本的长脉冲亚历山大激光。 使用alexandrite可以在近红外线中进行操作，特别是在围绕755的50nm范围内。在该范围内的红外线允许良好的穿透，同时仍然达到可接受的血红蛋白与黑色素吸收比。 在操作中，激光产生持续时间在5和100毫秒之间的脉冲，并且在10和50J / cm 2之间的通量。 提供了一种光输送系统，其将激光输出脉冲发送到患者的皮肤病学靶标。 本发明还涉及一种脱毛系统。 这里，期望在要处理的皮肤部分上使用折射率匹配应用，并且视觉指示器是热敏或光敏响应的或以其他方式响应于激光脉冲以产生可见变化。 这为操作者提供已经被处理的皮肤部分的记录。 最后，本发明涉及用于不需要的静脉的组合的硬化疗法和光治疗方法和试剂盒。 通过在光疗法和硬化疗法之间实施12个月至6个月之间的停留时间，在90-100％的范围内大大提高了成功率。 优选地，光硬化治疗在硬化治疗之前进行。 然而，通过在停留时间之后进行硬化治疗，然后进行基于光的治疗，可以实现成功。

    METHODS AND SYSTEMS FOR LASER TREATMENT USING NON-UNIFORM OUTPUT BEAM
    4.
    发明申请
    METHODS AND SYSTEMS FOR LASER TREATMENT USING NON-UNIFORM OUTPUT BEAM 审中-公开
    使用非均匀输出光束激光治疗的方法和系统

    公开(公告)号：WO2006116141A1

    公开(公告)日：2006-11-02

    申请号：PCT/US2006/015180

    申请日：2006-04-21

    Applicant: CYNOSURE, INC. ,  MIRKOV, Mirko, G. ,  SIERRA, Rafael, A. ,  CHO, George, E.S.

    Inventor： MIRKOV, Mirko, G. ,  SIERRA, Rafael, A. ,  CHO, George, E.S.

    IPC: A61N5/067 ,  A61N5/06 ,  A61B18/20

    CPC classification number: A61N5/0616 ,  A61B18/203 ,  A61B2018/00011 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2018/208 ,  A61B2018/2211 ,  G02B5/1885

    Abstract: Methods and apparatus for treatment, such as skin rejuvenation treatment, use non-uniform laser radiation. A high-intensity portion of the laser radiation causes collagen destruction and shrinkage within select portions of the treatment area, while a lower-intensity portion of the radiation causes fibroblast stimulation leading to collagen production across other portions of the treatment area. An output beam from a laser source, such as an Nd:YAG laser, is coupled into an optical system that modifies the beam to provide a large-diameter beam having a nonuniform energy profile, comprised of a plurality of high-intensity zones surrounded by lower-intensity zones within the treatment beam. The higher-intensity zones heat select portions of the target tissue to temperatures sufficient for a first treatment (e.g. collagen shrinkage), while the lower-intensity zones provide sufficient energy for a second treatment (e.g. stimulated collagen production). A large area of tissue, preferably 7-10 mm in diameter, can be treated simultaneously, while minimizing the risk of burning or other damage to the skin. In one embodiment, the invention uses a fiber bundle to provide a non-uniform energy output beam, hi another embodiment, the invention uses a diffractive lens array to produce the non-uniform output beam. A cooling system can also be integrated with the laser treatment system. A pulse light source can also be integrated with the laser treatment system in a combined skin rejuvenation therapy.

    Abstract translation: 治疗方法和设备，如皮肤复原治疗，使用不均匀的激光辐射。 激光辐射的高强度部分导致处理区域的选定部分内的胶原蛋白破坏和收缩，而辐射的较低强度部分引起成纤维细胞刺激，导致治疗区域的其它部分的胶原产生。 来自诸如Nd：YAG激光器的激光源的输出光束被耦合到光学系统中，该光学系统修改光束以提供具有不均匀能量分布的大直径光束，所述大直径光束包括被包围的多个高强度区域 处理梁内的较低强度区域。 较高强度区域将目标组织的部分热量选择为足以进行第一次处理（例如胶原收缩）的温度，而较低强度区域为第二次处理（例如刺激胶原产生）提供足够的能量。 可以同时治疗大面积的组织，优选直径为7-10mm，同时最小化对皮肤的燃烧或其它损伤的风险。 在一个实施例中，本发明使用纤维束来提供不均匀的能量输出束。在另一个实施例中，本发明使用衍射透镜阵列来产生不均匀的输出光束。 冷却系统也可以与激光治疗系统集成。 脉冲光源也可以与激光治疗系统整合在组合的皮肤年轻化疗法中。

    SYSTEM AND METHOD FOR LASER LIPOLYSIS
    5.
    发明申请
    SYSTEM AND METHOD FOR LASER LIPOLYSIS 审中-公开

    公开(公告)号：WO2006107522A3

    公开(公告)日：2006-10-12

    申请号：PCT/US2006/009006

    申请日：2006-03-10

    Applicant: EL. EN. S.P.A. ,  CHO, George, E., S. ,  MASOTTI, Leonardo

    Inventor： CHO, George, E., S. ,  MASOTTI, Leonardo

    IPC: A61B18/22

    Abstract: A device and related method for the removal of subcutaneous adipose layers comprises a laser source; an optical fiber for conveying a laser beam emitted by the laser source; and a hollow cannula for guiding the fiber to the subcutaneous treatment area. The cannula has a curved portion at its distal end, where the curved portion can be shaped to roughly conform to the contour of the patient's body structure. In this way, laser energy from the fiber, applied to the adipose layers, is generally directed away from the lower dermis of the patient, minimizing the risk of non-reversible damage to the dermis, including skin necrosis. In another embodiment, the optical fiber is a side-firing fiber that directs the laser energy away from the dermis. In other embodiments, a radiation detector, such as a thermal or optical sensor, monitors the temperature at the surface of the skin above the treatment area to warn the operator of harmful temperatures in the lower dermis. In another embodiment, a temperature sensitive material is applied to the surface of the skin above the treatment area to warn of harmful dermal temperatures. In another embodiment, a cooling mechanism cools the surface of the skin above the treatment area to prevent damage to the dermis.

    SYSTEM AND METHOD FOR LASER LIPOLYSIS
    6.
    发明申请
    SYSTEM AND METHOD FOR LASER LIPOLYSIS 审中-公开
    用于激光脂解的系统和方法

    公开(公告)号：WO2006107522A2

    公开(公告)日：2006-10-12

    申请号：PCT/US2006009006

    申请日：2006-03-10

    Applicant: EL EN SPA ,  CHO GEORGE E S ,  MASOTTI LEONARDO

    Inventor： CHO GEORGE E S ,  MASOTTI LEONARDO

    IPC: A61B18/22

    CPC classification number: A61B18/22 ,  A61B2017/00057 ,  A61B2017/00084 ,  A61B2018/00005 ,  A61B2018/2288 ,  A61B2090/3937 ,  A61B2562/0276

    Abstract: A device and related method for the removal of subcutaneous adipose layers comprises a laser source; an optical fiber for conveying a laser beam emitted by the laser source; and a hollow cannula for guiding the fiber to the subcutaneous treatment area. The cannula has a curved portion at its distal end, where the curved portion can be shaped to roughly conform to the contour of the patient's body structure. In this way, laser energy from the fiber, applied to the adipose layers, is generally directed away from the lower dermis of the patient, minimizing the risk of non-reversible damage to the dermis, including skin necrosis. In another embodiment, the optical fiber is a side-firing fiber that directs the laser energy away from the dermis. In other embodiments, a radiation detector, such as a thermal or optical sensor, monitors the temperature at the surface of the skin above the treatment area to warn the operator of harmful temperatures in the lower dermis. In another embodiment, a temperature sensitive material is applied to the surface of the skin above the treatment area to warn of harmful dermal temperatures. In another embodiment, a cooling mechanism cools the surface of the skin above the treatment area to prevent damage to the dermis.

    Abstract translation: 用于去除皮下脂肪层的装置和相关方法包括激光源; 用于传送由激光源发射的激光束的光纤; 以及用于将纤维引导到皮下治疗区域的中空套管。 套管在其远端处具有弯曲部分，其中弯曲部分可以被成形为大致符合患者身体结构的轮廓。 以这种方式，施加到脂肪层的来自纤维的激光能量通常远离患者的下部真皮，从而最小化对真皮的不可逆损伤的风险，包括皮肤坏死。 在另一个实施例中，光纤是将激光能量远离真皮的侧发光纤。 在其他实施例中，放射线检测器（例如热或光学传感器）监测处理区域上方皮肤表面的温度，以向操作者警告下层真皮中的有害温度。 在另一个实施方案中，将感温材料施加到处理区域上方的皮肤表面以警告有害的皮肤温度。 在另一个实施例中，冷却机构将治疗区域上方的皮肤表面冷却以防止对真皮的损伤。

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