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    PROCESSES FOR FORMING A DRUG DELIVERY DEVICE
    1.
    发明申请
    PROCESSES FOR FORMING A DRUG DELIVERY DEVICE 审中-公开
    用于形成药物递送装置的方法

    公开(公告)号：WO2003094888A1

    公开(公告)日：2003-11-20

    申请号：PCT/US2003/013733

    申请日：2003-05-01

    Applicant: CONTROL DELIVERY SYSTEMS, INC. ,  ASHTON, Paul ,  CHOU, Kang-Jye ,  GUO, Hong ,  SHIMIZU, Robert, W.

    Inventor： ASHTON, Paul ,  CHOU, Kang-Jye ,  GUO, Hong ,  SHIMIZU, Robert, W.

    IPC: A61K9/00

    CPC classification number: A61K9/209 ,  A61K9/0024 ,  A61K9/0092 ,  A61K9/284 ,  A61K9/2853 ,  A61K31/58 ,  A61K31/7072 ,  A61K45/06 ,  A61K2300/00

    Abstract: A drug delivery device can, in whole or in part, be formed by co-extruding a drug core and an outer tube. The outer tube may be permeable, semi-permeable, or impermeable to the drug. The drug core may include a polymer matrix which does not significantly affect the release rate of the drug. The outer tube, the polymer matrix of the drug core, or both may be bioerodible. The co-extruded product can be segmented into drug delivery devices. The devices may be left uncoated so that their respective ends are open, or the devices may be coated with, for example, a layer that is permeable to the drug, semi-permeable to the drug, or bioerodible.

    Abstract translation: 药物递送装置可以全部或部分地通过共挤出药物核心和外管来形成。 外管可以是可渗透的，半渗透的或不可渗透的药物。 药物核心可以包括不显着影响药物释放速率的聚合物基质。 外管，药物核心的聚合物基质或两者可以是生物可蚀性的。 共挤出产品可以分段成药物输送装置。 所述装置可以保持未涂覆，使得其各自的端部是开放的，或者所述装置可以涂覆有例如可渗透药物的层，药物半渗透性的或可生物侵蚀的。

    INJECTABLE SUSTAINED RELEASE DELIVERY DEVICES
    2.
    发明申请
    INJECTABLE SUSTAINED RELEASE DELIVERY DEVICES 审中-公开
    可注意的可持续发布的设备

    公开(公告)号：WO2005051234A2

    公开(公告)日：2005-06-09

    申请号：PCT/US2004035430

    申请日：2004-10-26

    Applicant: CONTROL DELIVERY SYS INC ,  CHOU KANG-JYE ,  GUO HONG ,  ASHTON PAUL ,  SHIMIZU ROBERT W ,  WATSON DAVID A

    Inventor： CHOU KANG-JYE ,  GUO HONG ,  ASHTON PAUL ,  SHIMIZU ROBERT W ,  WATSON DAVID A

    IPC: A61K9/00 ,  A61K9/20 ,  A61F2/00

    CPC classification number: A61K9/0024 ,  A61K9/0051 ,  A61K9/2095

    Abstract: An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as "coatings," "skins," or "outer layers"). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles. The device may be formed by combining at least one polymer, at least one drug, and at least one liquid solvent to form a liquid suspension or solution wherein, upon injection, such suspension or solution under goes a phase change and forms a gel. The configuration may provide for controlled release of the drug(s) for an extended period.

    Abstract translation: 可注射药物递送装置包括含有一种或多种药物的核心和一种或多种聚合物。 芯可以被一个或多个聚合物外层（本文中称为“涂层”，“表皮”或“外层”）包围。 在某些实施方案中，通过挤出或以其它方式预先形成用于药物核心的聚合物皮肤来形成装置。 药物核心可以与皮肤共挤出，或者在皮肤挤出后可以将其插入皮肤中，并可能固化。 在其它实施方案中，药物核心可以涂覆有一种或多种聚合物涂层。 这些技术可以有效地应用于制造具有广泛的药物制剂和皮肤的装置，其可以选择为以适合于使用标准或非标准的注射剂的形式控制药物核心中的药物的释放速率分布和各种其它性质， 标准规格针。 该装置可以通过组合至少一种聚合物，至少一种药物和至少一种液体溶剂以形成液体悬浮液或溶液而形成，其中在注射时，这样的悬浮液或溶液在变相下形成凝胶。 该配置可以提供长时间的药物的控制释放。

    INJECTABLE SUSTAINED RELEASE IMPLANT HAVING A BIOERODIBLE MATRIX CORE AND A BIOERODIBLE SKIN
    3.
    发明申请
    INJECTABLE SUSTAINED RELEASE IMPLANT HAVING A BIOERODIBLE MATRIX CORE AND A BIOERODIBLE SKIN 审中-公开

    公开(公告)号：WO2005051234A3

    公开(公告)日：2005-06-09

    申请号：PCT/US2004/035430

    申请日：2004-10-26

    Applicant: CONTROL DELIVERY SYSTEMS, INC. ,  CHOU, Kang-Jye ,  GUO, Hong ,  ASHTON, Paul ,  SHIMIZU, Robert, W. ,  WATSON, David, A.

    Inventor： CHOU, Kang-Jye ,  GUO, Hong ,  ASHTON, Paul ,  SHIMIZU, Robert, W. ,  WATSON, David, A.

    IPC: A61F2/00

    Abstract: An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as "coatings," "skins," or "outer layers"). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles. The device may be formed by combining at least one polymer, at least one drug, and at least one liquid solvent to form a liquid suspension or solution wherein, upon injection, such suspension or solution under goes a phase change and forms a gel. The configuration may provide for controlled release of the drug(s) for an extended period.

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