公开(公告)号：WO2008079575A1

公开(公告)日：2008-07-03

申请号：PCT/US2007/085620

申请日：2007-11-27

Applicant: MICRUS ENDOVASCULAR CORPORATION ,  LEVINE, Marc-Alan ,  HEBERT, Stephen ,  BRETON, Thomas, G. ,  WATSON, David, A.

Inventor： LEVINE, Marc-Alan ,  HEBERT, Stephen ,  BRETON, Thomas, G. ,  WATSON, David, A.

IPC: A61M25/00 ,  A61M25/01 ,  A61M25/09

CPC classification number: A61M25/008 ,  A61M25/0068 ,  A61M25/0136 ,  A61M25/0147 ,  A61M25/10 ,  A61M2025/015 ,  A61M2025/1079 ,  A61M2025/1093

Abstract: The long nose manipulatable catheter includes a main lumen (55), a wire lumen (60) with a push-pull wire (62) therethrough, and a flexible joint region. (58) The catheter section includes a control (240) including a handle (238) and a wire control (240) member engaging the push-pull wire for manipulating the flexible joint region. The push-pull wire (62) may be tapered, having a proximal portion of a first diameter and a smaller diameter distal portion. A coil may be placed around the smaller diameter to prevent buckling of the smaller diameter portion. A strapping coil may also disposed around the outside of the catheter,' and an outer covering may be disposed around the strapping. coil. An outer covering of a mesh may also be disposed around the distal tip of the catheter.

Abstract translation: 长鼻可操纵导管包括主腔（55），具有穿过其的推挽线（62）的线腔（60）和柔性接合区域。 （58）导管部分包括包括手柄（238）和接合推挽线的线控制（240）构件的控制器（240），用于操纵柔性接合区域。 推拉线（62）可以是锥形的，具有第一直径的近端部分和较小直径的远端部分。 线圈可以放置在较小直径周围以防止较小直径部分的弯曲。 捆扎线圈也可以围绕导管的外侧设置，并且可以在捆扎带周围设置外覆盖层。 线圈。 网的外覆盖物也可以设置在导管的远侧末端周围。

公开(公告)号：WO2013123021A1

公开(公告)日：2013-08-22

申请号：PCT/US2013/025900

申请日：2013-02-13

Applicant: WATSON, David A.

Inventor： WATSON, David A.

IPC: A61M5/00

CPC classification number: A61M27/006 ,  A61B17/00

Abstract: An improved shunt valve for the control of hydrocephalus provides for physiological atmospherically-referenced siphon control that is not adversely affected by overlying tissue. The valve includes one or more porous outer anti-fouling membranes to protect the flow control membranes from external mechanical tissue pressure, while permitting free movement of the flow control moveable membranes and permitting positive inlet pressure to regulate flow through the improved fluid shunt valve of the invention. The porous membranes are configured to prevent tissue ingrowth into the membranes pores while allowing adequate fluid flow across so as not to inhibit movement of the movable membrane.

Abstract translation: 用于控制脑积水的改进的分流阀提供生理大气参考的虹吸控制，其不受上覆组织的不利影响。 该阀包括一个或多个多孔外部防污膜，以保护流量控制膜免受外部机械组织压力，同时允许流动控制可移动膜的自由运动并且允许正入口压力来调节通过改进的流体分流阀 发明。 多孔膜被配置为防止组织向内生成膜孔，同时允许足够的流体流过，以便不会阻止活动膜的运动。

公开(公告)号：WO2009089216A3

公开(公告)日：2009-10-29

申请号：PCT/US2009030217

申请日：2009-01-06

Applicant: MICRUS ENDOVASCULAR CORP ,  LUNDKVIST ANDRE S ,  WATSON DAVID A

Inventor： LUNDKVIST ANDRE S ,  WATSON DAVID A

IPC: A61F2/90

CPC classification number: B23P13/00 ,  A61B17/12118 ,  A61B2017/00526 ,  A61F2/86 ,  A61F2/90 ,  A61F2210/0076 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0039 ,  A61F2250/0098 ,  Y10T29/4998

Abstract: The intravascular stent is formed from a composite wire includes an inner core (12) of radiopaque metal, a polymer layer (16) coaxially disposed about the inner core, and an outer metal layer (18) coaxially disposed about the polymer layer. The intermediary polymer layer acts as a barrier material between the inner core and the outer sheath, so that the inner core and outer sheath may e made of dissimilar metallic layers, and the intermediary polymer layer will prevent a galvanic reaction between the inner core and the peripheral metal layer. The intravascular stent (20) has ends (22,24) flared radially outwardly to prevent radially and longitudinally inward deformation of the ends of the stent when the stent is disposed in a desired location in a patient's vasculature.

Abstract translation: 血管内支架由复合线形成，该复合线包括不透射线金属的内芯（12），围绕内芯同轴设置的聚合物层（16）和围绕聚合物层同轴设置的外金属层（18）。 中间聚合物层用作内芯和外护套之间的阻挡材料，使得内芯和外护套可以由不同的金属层制成，并且中间聚合物层将防止内芯和外护套之间的电流反应 外围金属层。 血管内支架（20）具有端部（22,24），其端部（22,24）径向向外张开，以防止当支架设置在患者脉管系统中的期望位置时支架端部的径向和纵向向内变形。

公开(公告)号：WO2005008498A3

公开(公告)日：2006-08-17

申请号：PCT/CA2004001069

申请日：2004-07-21

Applicant: SYMBIUM CORP ,  SHANNON JOHN PARKER ,  BROWN THANE ,  MCCARTHY JOHN ,  WATSON DAVID A ,  WHITE ANTHONY RICHARD PHILLIP

Inventor： SHANNON JOHN PARKER ,  BROWN THANE ,  MCCARTHY JOHN ,  WATSON DAVID A ,  WHITE ANTHONY RICHARD PHILLIP

IPC: G06F11/30 ,  G06F11/07 ,  G06F11/34 ,  H04L12/26

CPC classification number: G06F21/50 ,  G06F11/0709 ,  G06F11/0751 ,  G06F11/0793 ,  G06F11/3055 ,  G06F11/3082 ,  G06F11/3409 ,  G06F11/3476 ,  G06F2201/815 ,  G06F2201/86 ,  G06F2201/87

Abstract: An administration system for use within a server system is provided. The server system having a server that provides host management functions and the server system being able to accept computer cards inserted therein. The administration system comprises a computing system that is inserted in the server system, the computing system having a controller that assumes control over the communications bus.

Abstract translation: 提供了一种在服务器系统内使用的管理系统。 服务器系统具有提供主机管理功能的服务器，并且服务器系统能够接收插入其中的计算机卡。 管理系统包括插入在服务器系统中的计算系统，该计算系统具有假设对通信总线的控制的控制器。

公开(公告)号：WO2005051234A3

公开(公告)日：2005-06-09

申请号：PCT/US2004/035430

申请日：2004-10-26

Applicant: CONTROL DELIVERY SYSTEMS, INC. ,  CHOU, Kang-Jye ,  GUO, Hong ,  ASHTON, Paul ,  SHIMIZU, Robert, W. ,  WATSON, David, A.

Inventor： CHOU, Kang-Jye ,  GUO, Hong ,  ASHTON, Paul ,  SHIMIZU, Robert, W. ,  WATSON, David, A.

IPC: A61F2/00

Abstract: An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as "coatings," "skins," or "outer layers"). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles. The device may be formed by combining at least one polymer, at least one drug, and at least one liquid solvent to form a liquid suspension or solution wherein, upon injection, such suspension or solution under goes a phase change and forms a gel. The configuration may provide for controlled release of the drug(s) for an extended period.

公开(公告)号：WO02070036A3

公开(公告)日：2003-03-06

申请号：PCT/US0206361

申请日：2002-02-28

Applicant: WATSON DAVID A

Inventor： WATSON DAVID A

IPC: A61M1/00 ,  A61L29/00 ,  A61M25/16 ,  A61M27/00 ,  A61M29/00

CPC classification number: A61M27/008 ,  A61M27/006 ,  A61M2210/0693 ,  Y10T29/49826

Abstract: A surgically implantable delivery or drainage catheter assembly (100) includes a porous fiber membrane (102) that is permeable to the intended drainage or delivery fluid, yet has an outer surface morphology and porosity that prevents the ingrowth of tissue. The porous fiber membrane (102) is created using a phase-inversion process which is controlled to select a desired porosity. A reinforcement member is also disposed within the porous fiber membrane (120).

Abstract translation: 手术可植入的输送或排出导管组件（100）包括对预期的排水或输送流体是可渗透的但具有防止组织向内生长的外表面形态和孔隙度的多孔纤维膜（102）。 多孔纤维膜（102）是使用控制以选择所需孔隙率的相转化方法产生的。 加强构件也设置在多孔纤维膜（120）内。

公开(公告)号：WO2009089218A3

公开(公告)日：2009-07-16

申请号：PCT/US2009/030220

申请日：2009-01-06

Applicant: MICRUS ENDOVASCULAR CORPORATION ,  LUNDKVIST, Andre, S. ,  WATSON, David, A.

Inventor： LUNDKVIST, Andre, S. ,  WATSON, David, A.

IPC: A61F2/90

Abstract: The intravascular stent is formed from a composite wire includes an inner core (12) of. radiopaque metal, a polymer layer (16) coaxially disposed abo.ut the inner core, and an outer metal layer (18) coaxially disposed about the polymer layer. The intermediary polymer layer acts as a barrier material between the inner core and the outer sheath, so that the inner core and outer sheath may be made of dissimilar metallic layers, and the intermediary polymer layer will prevent a galvanic reaction between the inner core and the peripheral metal layer. The intravascular stent (20) has ends (22, 24) flared radially outwardly to prevent radially and longitudinally inward deformation of the ends of the stent when the stent is disposed in a desired location in a patient's vasculature.

公开(公告)号：WO2009089216A2

公开(公告)日：2009-07-16

申请号：PCT/US2009/030217

申请日：2009-01-06

Applicant: MICRUS ENDOVASCULAR CORPORATION ,  LUNDKVIST, Andre, S. ,  WATSON, David, A.

Inventor： LUNDKVIST, Andre, S. ,  WATSON, David, A.

IPC: A61F2/90

CPC classification number: B23P13/00 ,  A61B17/12118 ,  A61B2017/00526 ,  A61F2/86 ,  A61F2/90 ,  A61F2210/0076 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0039 ,  A61F2250/0098 ,  Y10T29/4998

Abstract: The intravascular stent is formed from a composite wire includes an inner core of radiopaque metal, a polymer layer coaxially disposed about the inner core, and an outer metal layer coaxially disposed about the polymer layer. The intermediary polymer layer acts as a barrier material between the inner core and the outer sheath, so that the inner core and outer sheath may be made of dissimilar metallic layers, and the intermediary polymer layer will prevent a galvanic reaction between the inner core and the peripheral metal layer. The intravascular stent has ends flared radially outwardly to prevent radially and longitudinally inward deformation of the ends of the stent when the stent is disposed in a desired location in a patient's vasculature.

Abstract translation: 血管内支架由包含不透射线金属的内芯，围绕内芯同轴布置的聚合物层和围绕聚合物层共轴布置的外金属层的复合线形成。 中间聚合物层用作内芯和外护套之间的阻挡材料，使得内芯和外护套可以由不同金属层制成，并且中间聚合物层将防止内芯和外护套之间的电流反应 外围金属层。 血管内支架具有径向向外张开的端部，以防止当支架布置在患者脉管系统中的期望位置时支架端部的径向和纵向向内变形。

公开(公告)号：WO2005051234A2

公开(公告)日：2005-06-09

申请号：PCT/US2004035430

申请日：2004-10-26

Applicant: CONTROL DELIVERY SYS INC ,  CHOU KANG-JYE ,  GUO HONG ,  ASHTON PAUL ,  SHIMIZU ROBERT W ,  WATSON DAVID A

Inventor： CHOU KANG-JYE ,  GUO HONG ,  ASHTON PAUL ,  SHIMIZU ROBERT W ,  WATSON DAVID A

IPC: A61K9/00 ,  A61K9/20 ,  A61F2/00

CPC classification number: A61K9/0024 ,  A61K9/0051 ,  A61K9/2095

Abstract: An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as "coatings," "skins," or "outer layers"). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles. The device may be formed by combining at least one polymer, at least one drug, and at least one liquid solvent to form a liquid suspension or solution wherein, upon injection, such suspension or solution under goes a phase change and forms a gel. The configuration may provide for controlled release of the drug(s) for an extended period.

Abstract translation: 可注射药物递送装置包括含有一种或多种药物的核心和一种或多种聚合物。 芯可以被一个或多个聚合物外层（本文中称为“涂层”，“表皮”或“外层”）包围。 在某些实施方案中，通过挤出或以其它方式预先形成用于药物核心的聚合物皮肤来形成装置。 药物核心可以与皮肤共挤出，或者在皮肤挤出后可以将其插入皮肤中，并可能固化。 在其它实施方案中，药物核心可以涂覆有一种或多种聚合物涂层。 这些技术可以有效地应用于制造具有广泛的药物制剂和皮肤的装置，其可以选择为以适合于使用标准或非标准的注射剂的形式控制药物核心中的药物的释放速率分布和各种其它性质， 标准规格针。 该装置可以通过组合至少一种聚合物，至少一种药物和至少一种液体溶剂以形成液体悬浮液或溶液而形成，其中在注射时，这样的悬浮液或溶液在变相下形成凝胶。 该配置可以提供长时间的药物的控制释放。

公开(公告)号：WO2009089218A2

公开(公告)日：2009-07-16

申请号：PCT/US2009030220

申请日：2009-01-06

Applicant: MICRUS ENDOVASCULAR CORP ,  LUNDKVIST ANDRE S ,  WATSON DAVID A

Inventor： LUNDKVIST ANDRE S ,  WATSON DAVID A

IPC: A61F2/90

CPC classification number: B23P13/00 ,  A61B17/12118 ,  A61B2017/00526 ,  A61F2/86 ,  A61F2/90 ,  A61F2210/0076 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0039 ,  A61F2250/0098 ,  Y10T29/4998

Abstract: The intravascular stent is formed from a composite wire includes an inner core of radiopaque metal, a polymer layer coaxially disposed about the inner core, and an outer metal layer coaxially disposed about the polymer layer. The intermediary polymer layer acts as a barrier material between the inner core and the outer sheath, so that the inner core and outer sheath may be made of dissimilar metallic layers, and the intermediary polymer layer will prevent a galvanic reaction between the inner core and the peripheral metal layer. The intravascular stent has ends flared radially outwardly to prevent radially and longitudinally inward deformation of the ends of the stent when the stent is disposed in a desired location in a patient's vasculature.

Abstract translation: 血管内支架由复合线材形成，复合线材包括不透射线金属的内芯，围绕内芯同轴设置的聚合物层，以及围绕聚合物层同轴设置的外部金属层。 中间聚合物层用作内芯和外护套之间的阻挡材料，使得内芯和外护套可以由不同的金属层制成，并且中间聚合物层将防止内芯和外护套之间的电偶反应 外围金属层。 血管内支架具有径向向外张开的端部，以防止当支架置于患者脉管系统中的所需位置时，支架端部的径向和纵向向内变形。