公开(公告)号：WO2007029913A1

公开(公告)日：2007-03-15

申请号：PCT/KR2006/002782

申请日：2006-07-14

申请人： BIORANE CO., LTD ,  LEE, Young-Woo ,  CHU, Bo-Young

发明人： LEE, Young-Woo ,  CHU, Bo-Young

IPC分类号： A61L27/14

CPC分类号： A61L31/10 ,  A61L2400/12 ,  D01D5/003 ,  Y10T428/249921 ,  Y10T428/249988

摘要： The present invention relates to a multi-layered anti-adhesion barrier, particularly to a multi-layered anti-adhesion barrier comprising a nanofibrous structured base layer electrospun from a hydrophobic, biodegradable, biocompatible polymer and a polymer layer formed by coating a hydrophilic, biooriginated polymer on the base layer, and a method for the preparing the same. The multi-layered anti-adhesion barrier of the present invention can solve the problems of the conventional gel, solution, sponge, film or nonwoven type anti-adhesion systems, including adhesion to tissues or organs, flexibility, physical strength, ease of handling (ease of folding and bending), etc., offers improved user convenience. With a nanofibrous structure, the multi-layered anti-adhesion barrier of the present invention effectively blocks the infiltration or migration of blood and cells and promotes the healing of wounds. It is not torn or broken when folded or rolled and can be easily handled using small surgical instruments. Thus, it can minimize a foreign body reaction when used in various surgical operations.

摘要翻译： 本发明涉及一种多层抗粘连屏障，特别涉及一种多层抗粘连屏障，其包括由疏水性，可生物降解的生物相容性聚合物构成的纳米纤维结构化基层电纺丝，以及通过将亲水的，生物活化的 基材层上的聚合物及其制备方法。 本发明的多层防粘附屏障可以解决常规的凝胶，溶液，海绵，膜或非织造类型的抗粘连系统的问题，包括对组织或器官的粘附，柔韧性，体力，易于处理（ 折叠和弯曲的方便性）等，提供了改善的用户便利性。 利用纳米纤维结构，本发明的多层抗粘连屏障有效地阻止了血液和细胞的渗透或迁移，促进了伤口的愈合。 折叠或滚动时不会撕裂或破裂，可以使用小型手术器械轻松处理。 因此，当用于各种外科手术时，可以使异物反应最小化。