公开(公告)号：WO2009058331A3

公开(公告)日：2009-07-16

申请号：PCT/US2008012323

申请日：2008-10-29

Applicant: VERMILLLION INC ,  UNIV TEXAS ,  FUNG ERIC THOMAS ,  CLARKE CHARLOTTE ,  BAST ROBERT ,  COOMBES KEVIN

Inventor： FUNG ERIC THOMAS ,  CLARKE CHARLOTTE ,  BAST ROBERT ,  COOMBES KEVIN

IPC: G01N33/574 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68

CPC classification number: G01N33/57449 ,  G01N33/6848 ,  G01N2800/56

Abstract: The present invention provides methods and compositions for detecting early stage ovarian cancer in a patient. Also, methods for evaluating the ovarian cancer state of a patient are described herein. These methods involve the detection, analysis, and classification of biomarkers in biological samples.

Abstract translation: 本发明提供了用于检测患者早期卵巢癌的方法和组合物。 此外，本文描述了用于评估患者的卵巢癌状态的方法。 这些方法涉及生物样品中生物标志物的检测，分析和分类。

公开(公告)号：WO2009058331A2

公开(公告)日：2009-05-07

申请号：PCT/US2008/012323

申请日：2008-10-29

Applicant: VERMILLLION, INC. ,  THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  FUNG, Eric, Thomas ,  CLARKE, Charlotte ,  BAST, Robert ,  COOMBES, Kevin

Inventor： FUNG, Eric, Thomas ,  CLARKE, Charlotte ,  BAST, Robert ,  COOMBES, Kevin

IPC: G01N33/574 ,  G01N33/68 ,  G01N33/53 ,  G01N33/48 ,  G01N33/50

CPC classification number: G01N33/57449 ,  G01N33/6848 ,  G01N2800/56

Abstract: The present invention provides methods and compositions for detecting early stage ovarian cancer in a patient. Also, methods for evaluating the ovarian cancer state of a patient are described herein. These methods involve the detection, analysis, and classification of biomarkers in biological samples.

Abstract translation: 本发明提供了用于检测患者的早期卵巢癌的方法和组合物。 此外，本文描述了用于评估患者的卵巢癌状态的方法。 这些方法涉及生物样本中生物标志物的检测，分析和分类。

公开(公告)号：WO2008123948A1

公开(公告)日：2008-10-16

申请号：PCT/US2008/004088

申请日：2008-03-27

Applicant: VERMILLION, INC. ,  MD ANDERSON CANCER RESEARCH CENTER ,  FUNG, Eric, Thomas ,  BAST, Robert ,  PODUST, Vladimir ,  CLARKE, Charlotte

Inventor： FUNG, Eric, Thomas ,  BAST, Robert ,  PODUST, Vladimir ,  CLARKE, Charlotte

IPC: G01N33/53 ,  C07K16/00

CPC classification number: G01N33/57449 ,  G01N33/5091 ,  G01N2800/56 ,  G01N2800/60

Abstract: The present invention provides protein-based biomarkers andjbiomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, it has been found that the biomarkers set forth in Table 1 are biomarkers for ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.

Abstract translation: 本发明提供了可用于评估患者卵巢癌状态的基于蛋白质的生物标志物和生物标志物组合。 特别地，已经发现表1中列出的生物标志物是卵巢癌的生物标志物。 生物标志物可以通过SELDI质谱检测。