公开(公告)号：WO2012178064A3

公开(公告)日：2013-02-28

申请号：PCT/US2012043820

申请日：2012-06-22

Applicant: MAYO FOUNDATION ,  CLENDENEN STEVEN R ,  HAIDER CLIFTON R ,  GILBERT BARRY K ,  SPEES OLIVER WILLIAM

Inventor： CLENDENEN STEVEN R ,  HAIDER CLIFTON R ,  GILBERT BARRY K ,  SPEES OLIVER WILLIAM

IPC: A61B5/1455 ,  A61N1/34

CPC classification number: A61B5/14556 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4821 ,  A61B5/6826 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/746 ,  A61K49/0017

Abstract: A system and method for detecting vascular contamination by surgical anesthetic using non-invasive IR spectrophotometry. One embodiment is a method for operating an instrument such as an enhanced pulse oximeter to monitor a patient receiving local anesthetic marked with dye that absorbs infrared light. Light is applied to and detected from tissue of the patient. A signal representative of the detected light is processed to derive patient oxygenation information. The detected light is also processed to derive information representative of the presence of the dye-marked anesthetic. The oxygenation information and the information representative of the presence of anesthetic are displayed. The oxygenation monitoring and display and the anesthetic monitoring and display can occur separately or concurrently. Fluorescing dyes and fluorescence detection approaches are used for anesthetic detection in some embodiments. Other embodiments apply a sequence of light pulses and correlate the applied light pulse sequence to the detected signal to identify the presence of the dye-marked anesthetic.

Abstract translation: 一种使用非侵入式红外分光光度法检测外科麻醉药物血管污染的系统和方法。 一个实施例是用于操作诸如增强型脉搏血氧计的仪器的方法，以监测接收用吸收红外光的染料标记的局部麻醉剂的患者。 将光施加到患者的组织并从其检测。 处理表示检测到的光的信号以得到患者氧合信息。 检测到的光也被处理以得到表示染料标记的麻醉剂的存在的信息。 显示氧合信息和代表麻醉剂存在的信息。 氧合监测和显示以及麻醉监测和显示可以单独或同时发生。 在一些实施方案中，荧光染料和荧光检测方法用于麻醉检测。 其他实施例应用光脉冲序列并将所施加的光脉冲序列与检测到的信号相关联，以识别染料标记的麻醉剂的存在。

公开(公告)号：WO2012178064A2

公开(公告)日：2012-12-27

申请号：PCT/US2012/043820

申请日：2012-06-22

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ,  CLENDENEN, Steven R. ,  HAIDER, Clifton R. ,  GILBERT, Barry K. ,  SPEES, Oliver William

Inventor： CLENDENEN, Steven R. ,  HAIDER, Clifton R. ,  GILBERT, Barry K. ,  SPEES, Oliver William

IPC: A61B5/1455 ,  A61N1/34

CPC classification number: A61B5/14556 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4821 ,  A61B5/6826 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/746 ,  A61K49/0017 ,  G06F19/00

Abstract: A system and method for detecting vascular contamination by surgical anesthetic using non-invasive IR spectrophotometry. One embodiment is a method for operating an instrument such as an enhanced pulse oximeter to monitor a patient receiving local anesthetic marked with dye that absorbs infrared light. Light is applied to and detected from tissue of the patient. A signal representative of the detected light is processed to derive patient oxygenation information. The detected light is also processed to derive information representative of the presence of the dye-marked anesthetic. The oxygenation information and the information representative of the presence of anesthetic are displayed. The oxygenation monitoring and display and the anesthetic monitoring and display can occur separately or concurrently. Fluorescing dyes and fluorescence detection approaches are used for anesthetic detection in some embodiments. Other embodiments apply a sequence of light pulses and correlate the applied light pulse sequence to the detected signal to identify the presence of the dye-marked anesthetic.

Abstract translation: 一种使用非侵入式红外分光光度法检测外科麻醉药物血管污染的系统和方法。 一个实施例是用于操作诸如增强型脉搏血氧计的仪器的方法，以监测接收用吸收红外光的染料标记的局部麻醉剂的患者。 将光施加到患者的组织并从其检测。 处理表示检测到的光的信号以得到患者氧合信息。 检测到的光也被处理以得到表示染料标记的麻醉剂的存在的信息。 显示氧合信息和代表麻醉剂存在的信息。 氧合监测和显示以及麻醉监测和显示可以单独或同时发生。 在一些实施方案中，荧光染料和荧光检测方法用于麻醉检测。 其他实施例应用光脉冲序列并将所施加的光脉冲序列与检测到的信号相关联，以识别染料标记的麻醉剂的存在。