公开(公告)号：WO2004041830A2

公开(公告)日：2004-05-21

申请号：PCT/IB2003/004974

申请日：2003-11-06

Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LTD ,  DESHPANDE, Pandurang, Balwant ,  HOLKAR, Anil, Ganpat ,  KARALE, Sanjay, Nivrutti ,  JAFRI, Wajid, Sajjad ,  DAS, Gautam, Kumar

Inventor： DESHPANDE, Pandurang, Balwant ,  HOLKAR, Anil, Ganpat ,  KARALE, Sanjay, Nivrutti ,  JAFRI, Wajid, Sajjad ,  DAS, Gautam, Kumar

IPC: C07D495/04

CPC classification number: C07D495/04

Abstract: The present invention relates to an improved process for the preparation of optically active (+) biotin of formula (I) in pure form.

Abstract translation: 本发明涉及以纯形式制备式（I）的光学活性（+）生物素的改进方法。

公开(公告)号：WO2004050663A2

公开(公告)日：2004-06-17

申请号：PCT/IB2003/005563

申请日：2003-12-03

Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LTD ,  DESHPANDE, Pandurang, Balwant ,  DESHPANDE, Pramod, Narayan ,  KHADANGALE, Bhausaheb, Pandharinath ,  DAS, Gautam, Kumar ,  JEYAKUMAR, John Muthiah, Raja

Inventor： DESHPANDE, Pandurang, Balwant ,  DESHPANDE, Pramod, Narayan ,  KHADANGALE, Bhausaheb, Pandharinath ,  DAS, Gautam, Kumar ,  JEYAKUMAR, John Muthiah, Raja

IPC: C07D501/04

CPC classification number: C07D501/00

Abstract: The present invention relates to an improved process for the preparation of the sterile cefuroxime sodium of formula (I).

Abstract translation: 本发明涉及制备式（I）的无菌头孢呋辛钠的改进方法。

公开(公告)号：WO2004037833A1

公开(公告)日：2004-05-06

申请号：PCT/IB2003/004628

申请日：2003-10-21

Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LTD ,  DESHPANDE, Pramod, Narayan ,  DESHPANDE, Pandurang, Balwant ,  DAS, Gautam, Kumar ,  JOHN, MUTHIAH, Raja, Jeyakumar ,  KHADANGALE, Bhausaheb, Pandharinath

Inventor： DESHPANDE, Pramod, Narayan ,  DESHPANDE, Pandurang, Balwant ,  DAS, Gautam, Kumar ,  JOHN, MUTHIAH, Raja, Jeyakumar ,  KHADANGALE, Bhausaheb, Pandharinath

IPC: C07D501/06

CPC classification number: C07D501/00

Abstract: The present invention more particularly relates to a process for the preparation of cephalosporin antibiotics of the formula (I) wherein R 1 represents hydrogen, trityl, CH 3 , CR a R b COORY c where R a and R b independently represent hydrogen or methyl and R c represents hydrogen or (C 1 -C 6 )alkyl; R 2 is carboxylate ion or COOR d , where R d represents hydrogen, ester or a counter ion which forms a salt; R 3 represents hydrogen, CH 3 , CH 2 OCOCH 3 , CH=CH 2 .

Abstract translation: 本发明更具体地涉及一种制备式（I）的头孢菌素抗生素的方法，其中R 1表示氢，三苯甲基，CH 3，CR a R b COOR cc，其中R a和R b独立地表示氢或甲基，R c表示氢或（C 1 -C 6） 烷基; R2是羧酸根离子或COORd，其中Rd表示氢，酯或形成盐的抗衡离子; R3表示氢，CH3，CH2OCOCH3，CH = CH2。

公开(公告)号：WO2012160576A3

公开(公告)日：2013-03-28

申请号：PCT/IN2012000369

申请日：2012-05-25

Applicant: SEQUENT ANTI BIOTICS PRIVATE LTD ,  ANDREW GNANAPRAKASAM ,  GANAPATHY VEERAMANI ,  SYED IBRAHIM SHAHUL HAMEED ,  KARTHIKEYAN MURUGESAN ,  SIVASAMY THANGAVEL ,  MICHAEL SEKAR JEYARAJ ,  ARULMOLI THANGAVEL ,  DAS GAUTAM KUMAR

Inventor： ANDREW GNANAPRAKASAM ,  GANAPATHY VEERAMANI ,  SYED IBRAHIM SHAHUL HAMEED ,  KARTHIKEYAN MURUGESAN ,  SIVASAMY THANGAVEL ,  MICHAEL SEKAR JEYARAJ ,  ARULMOLI THANGAVEL ,  DAS GAUTAM KUMAR

IPC: C07D487/04 ,  A61K31/40

CPC classification number: A61K31/407

Abstract: The present invention relates to a novel, cost-effective process for the preparation of Sterile Meropenem Trihydrate, which is prepared by a) condensation of l-Azabicyclo[3.2.0]hepta-2-ene-2-carboxylic acid, 3- [(diphenoxyphosphinyl)oxy]-6-(l-hydroxyethyl)-4-methyl-7-oxo-(4-nitrobenzyl) methyl ester,[4R-[4a,5b,6b(R*)]] with (2S,4S)-2-(Dimethylaminqcarbonyl)-4- mercapto-l -(p-nitrobenzyloxycarbonyl)-l -pyrrolidine to obtain diprotected Meropenem; b) deprotection and hydrogenation of diprotected Meropenem to obtain non-sterile Meropenem Trihydrate; c) conversion of NS Meropenem Trihydrate into Sterile Meropenem Trihydrate by using water, methanolic ammonia solution and purging carbon dioxide gas.

Abstract translation: 本发明涉及一种用于制备无菌美罗培南三水合物的新型成本有效的方法，其通过以下步骤制备：a）将1-氮杂双环[3.2.0]庚-2-烯-2-羧酸3- [ （二苯氧基氧膦基）氧基] -6-（1-羟乙基）-4-甲基-7-氧代 - （4-硝基苄基）甲酯[4R- [4a，5b，6b（R *）]]与（2S，4S ）-2-（二甲基氨基羰基）-4-巯基-1-（对硝基苄氧基羰基）-1-吡咯烷，得到双重保护的美罗培南; b）去保护和加氢二倍体美罗培南以获得非消毒的美罗培南三水合物; c）通过使用水，甲醇氨溶液和吹扫二氧化碳气体，将NS美罗培南三水合物转化成无菌美罗培南三水合物。

公开(公告)号：WO2013021398A2

公开(公告)日：2013-02-14

申请号：PCT/IN2012/000540

申请日：2012-08-03

Applicant: SEQUENT SCIENTIFIC LIMITED ,  MANJATHURU, Mahalinga ,  MAYEKAR, Anil Narayan ,  DERAMBALA, Yogeesh ,  VASUDEVA, Pejakala Kakrannaya ,  ARULMOLI, Thangavel ,  DAS, Gautam Kumar

Inventor： MANJATHURU, Mahalinga ,  MAYEKAR, Anil Narayan ,  DERAMBALA, Yogeesh ,  VASUDEVA, Pejakala Kakrannaya ,  ARULMOLI, Thangavel ,  DAS, Gautam Kumar

IPC: C07D401/02

CPC classification number: C07D217/20

Abstract: The present invention discloses a novel, cost-effective process for preparation of [R-[R*,R*-(E)]]-2,2'-(l,8-dioxo-4-octene-l,8-diyl) bis(oxy- 3, 1-propanediyl) bis(l,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-l-[(3,4,5- trimethoxyphenyl)- methyl] isoquinolinium) dichloride, commonly known as mivacurium chloride, which avoids the conversion of (E)-4-octene-l,8-dioic acid to its acid chloride and use of non-ionic polymeric adsorbent resin to get a highly pure product.

Abstract translation: 本发明公开了一种用于制备[R- [R *，R * - （E）] - 2,2' - （1,8-二氧代 - （氧代-3,1-丙二基）二（1,2,3,4-四氢-6,7-二甲氧基-2-甲基-1 - [（3,4-辛烯-1,8-二基） （三甲氧基苯基） - 甲基]异喹啉鎓）二氯化物，通常称为氯化米库氯铵，其避免（E）-4-辛烯-1,8-二酸转化为其酰基氯并且使用非离子聚合物吸附树脂 得到一个高度纯净的产品。

公开(公告)号：WO2004041830A3

公开(公告)日：2005-05-26

申请号：PCT/IB0304974

申请日：2003-11-06

Applicant: ORCHID CHEMICALS & PHARM LTD ,  DESHPANDE PANDURANG BALWANT ,  HOLKAR ANIL GANPAT ,  KARALE SANJAY NIVRUTTI ,  JAFRI WAJID SAJJAD ,  DAS GAUTAM KUMAR

Inventor： DESHPANDE PANDURANG BALWANT ,  HOLKAR ANIL GANPAT ,  KARALE SANJAY NIVRUTTI ,  JAFRI WAJID SAJJAD ,  DAS GAUTAM KUMAR

IPC: C07D495/04

CPC classification number: C07D495/04

Abstract: The present invention relates to an improved process for the preparation of optically active (+) biotin of formula (I) in pure form.

Abstract translation: 本发明涉及以纯形式制备式（I）的光学活性（+）生物素的改进方法。

公开(公告)号：WO2004037832A1

公开(公告)日：2004-05-06

申请号：PCT/IB2002/005313

申请日：2002-12-10

Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED ,  DESHPANDE, Pandurang, Balwant ,  DAS, Gautam, Kumar ,  DESHPANDE, Pramod, Narayan ,  CHANDRASEKARAN, Ramasubbu ,  RAMAR, Padmanabhan ,  JEYAKUMAR, John, Muthiah, Raja

Inventor： DESHPANDE, Pandurang, Balwant ,  DAS, Gautam, Kumar ,  DESHPANDE, Pramod, Narayan ,  CHANDRASEKARAN, Ramasubbu ,  RAMAR, Padmanabhan ,  JEYAKUMAR, John, Muthiah, Raja

IPC: C07D501/00

CPC classification number: C07D501/00

Abstract: The present invention provides an improved process for the preparation of cefixime of formula (I) from the corresponding alkyl ester, with an improved quality having/possessing better color and solubility. The ester hydrolysis is carried out in a biphasic system by using sodium bicarbonate and sodium hydroxide.

Abstract translation: 本发明提供了从相应的烷基酯制备式（I）头孢克肟的改进方法，具有/具有更好的颜色和溶解度的改进的质量。 酯水解通过使用碳酸氢钠和氢氧化钠在双相体系中进行。

公开(公告)号：WO2004035593A1

公开(公告)日：2004-04-29

申请号：PCT/IB2002/005335

申请日：2002-12-10

Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED ,  DESHPANDE, Pramod, Narayan ,  DAS, Gautam, Kumar ,  SARANGDHAR, Rajendra, Janardan ,  THARIAL, Peter, Xavier

Inventor： DESHPANDE, Pramod, Narayan ,  DAS, Gautam, Kumar ,  SARANGDHAR, Rajendra, Janardan ,  THARIAL, Peter, Xavier

IPC: C07D501/06

CPC classification number: C07D501/00

Abstract: The present invention relates to an improved process for the preparation of cefadroxil of the Formula (I), more particularly, the present invention relates to an improved process for the preparation of cefadroxil having water content in the range of 4-5 %.

Abstract translation: 本发明涉及一种制备式（I）头孢羟氨苄的改进方法，更具体地说，本发明涉及一种制备水含量在4-5％范围内的头孢羟氨苄的改进方法。

公开(公告)号：WO2003059914A1

公开(公告)日：2003-07-24

申请号：PCT/IB2002/000125

申请日：2002-01-15

Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED ,  DESHPANDE, Pramod, Narayan ,  KHADANGALE, Bhausaheb, Pandharinath ,  KUMAR, Surulichamy, Senthil ,  DAS, Gautam, Kumar

Inventor： DESHPANDE, Pramod, Narayan ,  KHADANGALE, Bhausaheb, Pandharinath ,  KUMAR, Surulichamy, Senthil ,  DAS, Gautam, Kumar

IPC: C07D501/04

CPC classification number: C07D501/00

Abstract: The present invention provides an improved process for the preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxylic acid represented by formula (I) (I)by the condensation of 7-amino cephalosporanic acid (7-ACA) represented by formula (II) with furyl-2-carbonylthiol represented by formula (III) using borontrifluoride as condensing agent in an organic solvent at a temperature range of 20 °-50 °C.

Abstract translation: 本发明提供了一种改进的制备由式（I）（I）表示的7-氨基-3- [2-（呋喃基）硫代甲基] -3-头孢烯-4-羧酸通过7-氨基 由式（II）表示的头孢菌酸（7-ACA）与式（III）所示的呋喃-2-羰基硫醇在有机溶剂中，在温度范围为20-50℃下，使用三氟化硼作为缩合剂。

公开(公告)号：WO2012160576A2

公开(公告)日：2012-11-29

申请号：PCT/IN2012/000369

申请日：2012-05-25

Applicant: SEQUENT ANTI BIOTICS PRIVATE LIMITED ,  ANDREW, Gnanaprakasam ,  GANAPATHY, Veeramani ,  SYED IBRAHIM, Shahul Hameed ,  KARTHIKEYAN, Murugesan ,  SIVASAMY, Thangavel ,  MICHAEL, Sekar Jeyaraj ,  ARULMOLI, Thangavel ,  DAS, Gautam Kumar

Inventor： ANDREW, Gnanaprakasam ,  GANAPATHY, Veeramani ,  SYED IBRAHIM, Shahul Hameed ,  KARTHIKEYAN, Murugesan ,  SIVASAMY, Thangavel ,  MICHAEL, Sekar Jeyaraj ,  ARULMOLI, Thangavel ,  DAS, Gautam Kumar

IPC: A61K31/407

CPC classification number: A61K31/407

Abstract: The present invention relates to a novel, cost-effective process for the preparation of Sterile Meropenem Trihydrate, which is prepared by a) condensation of l-Azabicyclo[3.2.0]hepta-2-ene-2-carboxylic acid, 3- [(diphenoxyphosphinyl)oxy]-6-(l-hydroxyethyl)-4-methyl-7-oxo-(4-nitrobenzyl) methyl ester,[4R-[4a,5b,6b(R*)]] with (2S,4S)-2-(Dimethylaminqcarbonyl)-4- mercapto-l -(p-nitrobenzyloxycarbonyl)-l -pyrrolidine to obtain diprotected Meropenem; b) deprotection and hydrogenation of diprotected Meropenem to obtain non-sterile Meropenem Trihydrate; c) conversion of NS Meropenem Trihydrate into Sterile Meropenem Trihydrate by using water, methanolic ammonia solution and purging carbon dioxide gas.

Abstract translation: 本发明涉及一种用于制备无菌美罗培南三水合物的新型成本有效的方法，其通过以下步骤制备：a）将1-氮杂双环[3.2.0]庚-2-烯-2-羧酸3- [ （二苯氧基氧膦基）氧基] -6-（1-羟乙基）-4-甲基-7-氧代 - （4-硝基苄基）甲酯[4R- [4a，5b，6b（R *）]]与（2S，4S ）-2-（二甲基氨基羰基）-4-巯基-1-（对硝基苄氧基羰基）-1-吡咯烷，得到双重保护的美罗培南; b）去保护和加氢二倍体美罗培南以获得非消毒的美罗培南三水合物; c）通过使用水，甲醇氨溶液和吹扫二氧化碳气体，将NS美罗培南三水合物转化成无菌美罗培南三水合物。