公开(公告)号：WO2005070930A2

公开(公告)日：2005-08-04

申请号：PCT/US2005/002270

申请日：2005-01-24

Applicant: CHIRON CORPORATION ,  WANG, Weibo ,  NI, Zhi-Jie ,  BARSANTI, Paul ,  PECCHI, Sabina ,  XIA, Yi ,  BRAMMEIER, Nathan ,  TREUTLE, Megan ,  JAZAN, Elisa ,  WAYMAN, Kelly ,  DIBBLE, David ,  CHENG, Jie-Kai

Inventor： WANG, Weibo ,  NI, Zhi-Jie ,  BARSANTI, Paul ,  PECCHI, Sabina ,  XIA, Yi ,  BRAMMEIER, Nathan ,  TREUTLE, Megan ,  JAZAN, Elisa ,  WAYMAN, Kelly ,  DIBBLE, David ,  CHENG, Jie-Kai

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Tetrahydrocarboline compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.

Abstract translation: 四氢咔啉化合物，其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种四氢咔啉化合物的组合物，单独或与至少一种另外的治疗剂组合。 单独使用四氢咔啉化合物或与至少一种另外的治疗剂组合使用的方法可用于预防或治疗增殖性疾病。

公开(公告)号：WO2005070930A3

公开(公告)日：2006-01-19

申请号：PCT/US2005002270

申请日：2005-01-24

Applicant: CHIRON CORP ,  WANG WEIBO ,  NI ZHI-JIE ,  BARSANTI PAUL ,  PECCHI SABINA ,  XIA YI ,  BRAMMEIER NATHAN ,  TREUTLE MEGAN ,  JAZAN ELISA ,  WAYMAN KELLY ,  DIBBLE DAVID ,  CHENG JIE-KAI

Inventor： WANG WEIBO ,  NI ZHI-JIE ,  BARSANTI PAUL ,  PECCHI SABINA ,  XIA YI ,  BRAMMEIER NATHAN ,  TREUTLE MEGAN ,  JAZAN ELISA ,  WAYMAN KELLY ,  DIBBLE DAVID ,  CHENG JIE-KAI

IPC: A61K31/4745 ,  C07D471/02 ,  C07D471/04 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: Tetrahydrocarboline compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.

Abstract translation: 四氢咔啉化合物，其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种四氢咔啉化合物的组合物，单独或与至少一种其它治疗剂组合。 单独使用四氢咔啉化合物或与至少一种另外的治疗剂组合使用的方法可用于预防或治疗增殖性疾病。