公开(公告)号：WO2011069472A1

公开(公告)日：2011-06-16

申请号：PCT/CZ2010/000123

申请日：2010-12-06

Applicant: USTAV ORGANICKÉ CHEMIE A BIOCHEMIE AKADEMIE VĚD ČESKÉ REPUBLIKY, V.V.I. ,  ZENTIVA, K.S. ,  BÁRTA, Jaroslav ,  MUDRA, Petr ,  PEŠEK, Václav ,  PONCAR, Pavel ,  DOHNAL, Jiří ,  JAMPÍLEK, Josef ,  KRÁL. Vladimír ,  POKORNÝ, Vít ,  ŘEZÁČOVÁ, Anna

Inventor： BÁRTA, Jaroslav ,  MUDRA, Petr ,  PEŠEK, Václav ,  PONCAR, Pavel ,  DOHNAL, Jiří ,  JAMPÍLEK, Josef ,  KRÁL. Vladimír ,  POKORNÝ, Vít ,  ŘEZÁČOVÁ, Anna

IPC: G09B23/30 ,  G09B23/32 ,  B01F11/00

CPC classification number: G09B23/30 ,  B01F11/0065 ,  G09B23/32

Abstract: A digestive tract simulator, comprising hydraulically interconnected at least two elastic bags (12) kept at the constant temperature and a controllable heating source, wherein a heating source is represented by a heated temperating plate (2) over whose working surface intended for placing of elastic bags (12) two levers (7) are arranged in an axial distance, swinging around a common axis; to these levers (7) a deflected wing (3) placed in parallel with the temperating plate (2) and having working arms opened in a wide angle in direction from the temperating plate (2) is mounted on the lever's side near to the temperating plate (2); at least one of levers (7) is connected to a pendulum engine (4) having an adjustable motion so that elastic bags (12) are in operating state situated between the working surface of the temperating plate (2) and the deflected wing (3); each of bags (12) is equipped by an air cock (127) and an input and output pipe channel (126) for working medium, connecting bags (12) together via tubing coupled through a peristaltic pump (5).

Abstract translation: 一种消化道模拟器，包括保持在恒定温度下的液压互连的至少两个弹性袋（12）和可控加热源，其中加热源由加热的温度盘（2）表示，其工作表面用于放置弹性 袋（12）两个杆（7）以轴向方式布置，围绕公共轴线摆动; 在这些杠杆（7）上，与温化板（2）平行放置并且具有沿着与温化板（2）的方向广角的打开的工作臂的偏转翼（3）安装在靠近温度的杆的一侧 板（2）; 杠杆（7）中的至少一个连接到具有可调节运动的摆锤发动机（4），使得弹性袋（12）处于位于调温板（2）的工作表面和偏转翼（3）之间的操作状态 ）; 每个袋（12）由用于工作介质的空气旋塞（127）和输入和输出管道（126）配备，通过经由蠕动泵（5）连接的管通过连接袋（12）在一起。

公开(公告)号：WO2013020527A1

公开(公告)日：2013-02-14

申请号：PCT/CZ2012/000073

申请日：2012-08-02

Applicant: UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES BRNO FACULTY OF PHARMACY ,  JAMPÍLEK, Josef ,  OPATŘILOVÁ, Radka ,  COUFALOVÁ, Lenka ,  ČERNÍKOVÁ, Aneta ,  DOHNAL, Jiří

Inventor： JAMPÍLEK, Josef ,  OPATŘILOVÁ, Radka ,  COUFALOVÁ, Lenka ,  ČERNÍKOVÁ, Aneta ,  DOHNAL, Jiří

IPC: A61K9/06 ,  A61K9/14 ,  A61K47/10 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38 ,  A61K9/00

CPC classification number: A61K9/0014 ,  A61K9/06 ,  A61K9/5138 ,  A61K47/22

Abstract: The invention deals with the way of utilization of micronized, nanonized and/or surface-modified alaptide, which affects penetration of other pharmaceutically active compounds through the skin as a pharmaceutical adjuvant (excipient). These pharmaceutical compositions composed of alaptide as the excipient, pharmaceutical active ingredients (non-steroidal anti-inflammatory drugs and/or antipyretics/non-opiate analgesics and/or glucocorticoids and/or antimicrobial chemotherapeutics, i.e. antibacterials, antimycotics, antivirotics) and other pharmaceutical excipients can be used for preparation of drug formulations, which can influence the drug level in the body in time and can be used for both local and systemic administration.

Abstract translation: 本发明涉及利用微粉化，纳米化和/或表面改性的洗涤剂的方式，其影响其它药物活性化合物作为药物佐剂（赋形剂）穿过皮肤的渗透。 作为赋形剂的组合物，药物活性成分（非甾体抗炎药和/或解热药/非阿片类镇痛药和/或糖皮质激素和/或抗微生物化学治疗剂，即抗细菌剂，抗真菌剂，抗真菌剂）和其它药物 赋形剂可用于制备药物制剂，其可以及时影响身体的药物水平，并且可用于局部和全身给药。