公开(公告)号：WO2005115105A3

公开(公告)日：2005-12-08

申请号：PCT/US2005/016301

申请日：2005-05-10

Applicant: NORTHWESTERN UNIVERSITY ,  DUIMSTRA, Joseph, A. ,  MEADE, Thomas, J.

Inventor： DUIMSTRA, Joseph, A. ,  MEADE, Thomas, J.

IPC: A61K49/00

Abstract: The present invention relates to magnetic resonance imaging (MRI) contrast agent. In particular, the present invention provides MRI contrast agents that are sensitive to the enzyme beta-glucoronidase. The MRI contrast agents provide compositions and methods for non-invasive diagnostic imaging of tissues, including necrotic tumors.

公开(公告)号：WO2005115105A2

公开(公告)日：2005-12-08

申请号：PCT/US2005016301

申请日：2005-05-10

Applicant: UNIV NORTHWESTERN ,  DUIMSTRA JOSEPH A ,  MEADE THOMAS J

Inventor： DUIMSTRA JOSEPH A ,  MEADE THOMAS J

IPC: A61K47/48 ,  A61K49/10

CPC classification number: A61K49/085 ,  A61K47/555 ,  A61K49/10

Abstract: The present invention relates to magnetic resonance imaging (MRI) contrast agent. In particular, the present invention provides MRI contrast agents that are sensitive to the enzyme beta-glucoronidase. The MRI contrast agents provide compositions and methods for non-invasive diagnostic imaging of tissues, including necrotic tumors.

Abstract translation: 本发明涉及磁共振成像（MRI）造影剂。 特别地，本发明提供对β-葡萄糖醛酸酶敏感的MRI造影剂。 MRI造影剂提供用于组织非侵入性诊断成像（包括坏死性肿瘤）的组合物和方法。

公开(公告)号：WO2010111531A3

公开(公告)日：2011-01-20

申请号：PCT/US2010028726

申请日：2010-03-25

Applicant: SENOVA SYSTEMS INC ,  LEONARD LEE ,  DUIMSTRA JOSEPH A ,  LEE ERIC ,  MICKLATCHER MARK ,  SIMONYI VICTOR ,  WILDGOOSE GREG ,  KETO JOSEPH I ,  SEIDEL ANTON

Inventor： LEONARD LEE ,  DUIMSTRA JOSEPH A ,  LEE ERIC ,  MICKLATCHER MARK ,  SIMONYI VICTOR ,  WILDGOOSE GREG ,  KETO JOSEPH I ,  SEIDEL ANTON

IPC: G01N27/30 ,  G01N27/26 ,  G01N27/416 ,  G01N33/18

CPC classification number: G01N27/4166 ,  G01N27/302 ,  G01N27/4167

Abstract: Devices for detecting an analyte comprising a redox active analyte sensitive material on a working electrode and computer assisted signal acquisition and processing.

Abstract translation: 用于在工作电极上检测包含氧化还原活性分析物敏感材料的分析物的设备以及计算机辅助信号采集和处理。

公开(公告)号：WO2010111531A9

公开(公告)日：2010-09-30

申请号：PCT/US2010/028726

申请日：2010-03-25

Applicant: SENOVA SYSTEMS, INC. ,  LEONARD, Lee ,  DUIMSTRA, Joseph A. ,  LEE, Eric ,  MICKLATCHER, Mark ,  SIMONYI, Victor ,  WILDGOOSE, Greg ,  KETO, Joseph I. ,  SEIDEL, Anton

Inventor： LEONARD, Lee ,  DUIMSTRA, Joseph A. ,  LEE, Eric ,  MICKLATCHER, Mark ,  SIMONYI, Victor ,  WILDGOOSE, Greg ,  KETO, Joseph I. ,  SEIDEL, Anton

IPC: G01N27/30 ,  G01N27/416 ,  G01N33/18 ,  G01N27/26

Abstract: Devices for detecting an analyte comprising a redox active analyte sensitive material on a working electrode and computer assisted signal acquisition and processing.

公开(公告)号：WO2010111531A2

公开(公告)日：2010-09-30

申请号：PCT/US2010028726

申请日：2010-03-25

Applicant: SENOVA SYSTEMS INC ,  LEONARD LEE ,  DUIMSTRA JOSEPH A ,  LEE ERIC ,  MICKLATCHER MARK ,  SIMONYI VICTOR ,  WILDGOOSE GREG ,  KETO JOSEPH I ,  SEIDEL ANTON

Inventor： LEONARD LEE ,  DUIMSTRA JOSEPH A ,  LEE ERIC ,  MICKLATCHER MARK ,  SIMONYI VICTOR ,  WILDGOOSE GREG ,  KETO JOSEPH I ,  SEIDEL ANTON

IPC: G01N27/30 ,  G01N27/26 ,  G01N27/416 ,  G01N33/18

CPC classification number: G01N27/4166 ,  G01N27/302 ,  G01N27/4167

Abstract: Devices for detecting an analyte comprising a redox active analyte sensitive material on a working electrode and computer assisted signal acquisition and processing.

Abstract translation: 用于检测包括在工作电极上的氧化还原活性分析物敏感材料的分析物和计算机辅助信号采集和处理的装置。

公开(公告)号：WO2010104962A1

公开(公告)日：2010-09-16

申请号：PCT/US2010/026842

申请日：2010-03-10

Applicant: SENOVA SYSTEMS, INC. ,  DUIMSTRA, Joseph, A. ,  LEONARD, Lee ,  WILDGOOSE, Gregory, G. ,  LEE, Eric

Inventor： DUIMSTRA, Joseph, A. ,  LEONARD, Lee ,  WILDGOOSE, Gregory, G. ,  LEE, Eric

IPC: G01N27/30 ,  G01N27/26

CPC classification number: G01N27/302 ,  B82Y30/00 ,  C25B11/00 ,  G01N27/301 ,  G01N27/333 ,  G01N27/36 ,  Y10S977/742

Abstract: Internally calibrated pH and other analyte sensors based on redox agents provide more accurate results when the redox active reference agent is in a constant chemical environment, yet separated from the solution being analyzed in such a way as to maintain electrical contact with the sample. Room temperature ionic liquids (RTIL) can be used to achieve these results when used as a salt bridge between the reference material and the sample being analyzed. The RTIL provides the constant chemical environment and ionic strength for the redox active material (RAM) and provides an electrolytic layer that limits or eliminates direct chemical interaction with the sample. A broad range of RAMs can be employed in a variety of configurations in such "Analyte Insensitive Electrode" devices.

Abstract translation: 当氧化还原活性参考试剂处于恒定的化学环境中时，内部校准的pH值和其它基于氧化还原剂的分析物传感器可提供更精确的结果，但与被分析的溶液分离，以保持与样品的电接触。 当用作参考物质和正在分析的样品之间的盐桥时，室温离子液体（RTIL）可用于实现这些结果。 RTIL为氧化还原活性材料（RAM）提供恒定的化学环境和离子强度，并提供限制或消除与样品的直接化学相互作用的电解质层。 在这种“分析物不敏感电极”装置中，可以采用各种各样的配置的宽范围的RAM。