公开(公告)号：WO2016054295A1

公开(公告)日：2016-04-07

申请号：PCT/US2015/053370

申请日：2015-09-30

Applicant: DXNOW INC. ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  KLEVAN, Leonard ,  DEMIRCI, Utkan ,  INCI, Fatih

Inventor： KLEVAN, Leonard ,  DEMIRCI, Utkan ,  INCI, Fatih

IPC: C12M1/34 ,  C12M3/00 ,  C12Q1/68

CPC classification number: B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0816 ,  C12N15/1003 ,  C12Q1/24 ,  G01N1/405

Abstract: Embodiments of the present disclosure relate to a platform for at least one of capturing, identifying and studying biological materials, and more particularly, to microfluidic channel platforms (for example) for detecting and/or identifying samples containing sperm cells, and isolating and analyzing captured sperm cells for DNA analysis (for example). In some embodiments, such microfluidic platforms integrate imaging technology. Such embodiments provide the ability to at least one of rapidly isolate and quantitate sperm cells from biological mixtures as occur in sexual assault evidence, for example, thereby enhancing identification of suspects in these cases and contributing to the safety of society.

Abstract translation: 本公开的实施方案涉及用于捕获，鉴定和研究生物材料，更具体地，涉及用于检测和/或识别含有精子细胞的样品的微流体通道平台（例如）的至少一个的平台，以及分离和分析捕获的 用于DNA分析的精子细胞（例如）。 在一些实施例中，这种微流体平台集成成像技术。 这样的实施例提供了在性攻击证据中发生的从生物混合物中快速分离和定量精子细胞中的至少一种的能力，从而增强了在这些情况下的嫌疑人的识别并有助于社会的安全。