摘要:
본 발명은 전자동 유전자 판별 통합설비에 관한 것으로, 보다 상세하게는 전자동으로 검출대상균의 유전자를 신속하게 판별할 수 있도록 하기 위한 전자동 유전자 판별 통합설비에 관한 것이다. 본 발명의 구성은 상부에 전자동 유전자 판별 통합칩이 장착되며, 외형을 형성하는 본체모듈; 상기 본체모듈의 상부에 마련되며, 전방으로 회동시 상기 전자동 유전자 판별 통합칩의 상부를 덮도록 마련되는 상부모듈; 상기 상부모듈에 결합되며, 상기 전자동 유전자 판별 통합칩 내 유체의 흐름을 제어하도록 마련되는 유동모듈; 상기 본체모듈에 마련되며, 상기 전자동 유전자 판별 통합칩의 증폭기의 하측에 마련되는 증폭모듈; 상기 본체모듈의 상부에 마련되며, 상기 전자동 유전자 판별 통합칩의 전극유닛과 연결되도록 마련되는 판별모듈; 및 상기 본체모듈에 마련되는 제어모듈을 포함하며, 상기 판별모듈은 혼합물질의 전류량을 측정하여 유전자를 판별하는 것을 특징으로 하는 전자동 유전자 판별 통합설비를 제공한다.
摘要:
A sensor system includes an array of conductive elements, an electrode proximate to the array, column selection circuitry, a plurality of readout circuits and a plurality of analog-to-digital converters. The electrode and the array of conductive elements define a cavity configured to receive a fluid sample. The electrode is configured to transmit at least one electrical signal through the fluid sample. The column selection circuitry is configured to select a column of conductive elements from the array. The readout circuits are coupled to respective ones of M rows of conductive elements in the array and are configured to receive signals from respective conductive elements of a selected column of conductive elements. The readout circuits are further configured to generate readout signals based on the signals received from the respective conductive elements. The analog-to-digital converters are configured to convert the readout signals into digital signals.
摘要:
An integrated technological platform enabling real-time quantitative multiparameter metabolic profiling, utilizing either or both of extra and intracellular optical sensors, individually or simultaneously. A scalable embedded micropocket array structure, generally fabricated on fused silica substrates, facilitates the integration of multiple, spatially separated extracellular sensors for multiparameter analysis in a container formed with the use of an activation mechanism forming part of a device configured to hold the container during the measurements. The creation of hermetically sealed microchambers is carried out with a pneumatically and/or mechanically and/or electromechanically driven device that is "floating" within the holding device and that is optionally equipped with a vacuum/suction mechanism to hold a component of the container at its surface.
摘要:
A point-of-care medical testing system integrated with a patient monitor is disclosed. The system may include a microfluidic cartridge configured to receive a blood sample and generate a sensory signal dependent on a concentration of a biomarker in the blood sample. A cartridge reading assembly receives the microfluidic cartridge. The cartridge reading assembly includes a processing unit and a memory coupled with the processing unit. The memory stores executable instructions to cause the processing unit to receive the sensory signal, correlate the received sensory signal with the concentration of the biomarker in the blood sample, and produce an output representative of the concentration of the biomarker in the blood sample. The cartridge reading assembly is coupled to the patient monitor and configured to send the output to the patient monitor.
摘要:
A cartridge for sample handling and sensing includes a sample port connected to a sample reservoir having a proximal end, a proximal region adjacent the proximal end, and a distal end opposite of the proximal end. The cartridge also includes a first fluid port connected to the sample reservoir in the distal region via a first fluid channel; and a second fluid port connected to the sample reservoir in the proximal region via a second fluid channel. In addition, the cartridge includes a sensor platform comprising a bulk acoustic wave (BAW) resonator and a fluid flow path comprising a sensing region extending across a sensing surface of the BAW resonator. The cartridge further includes a fluid valve between the distal end of the sample reservoir and the sensing region. A sample may be applied to the sample port; first volume of fluid may be injected through the first fluid port; and then a second volume of fluid may be injected through the second fluid port to drive the sample into the sensing region of the fluid flow path.
摘要:
A sequencing instrument including a sequencing stage and a microscope. The sequencing stage has a reference plate with a flat reference surface. The microscope optical axis is perpendicular to the reference surface. The sequencing stage is configured to receive a flexible film having a plurality of DNA templates immobilized on a first side of the film, and to hold the flexible film against the flat reference surface with at least some of the plurality of DNA templates in an object plane that is perpendicular to the microscope's optical axis.
摘要:
A fluidic device (100) is described for locally coating an inner surface of a fluidic channel. The fluidic device (100) comprises a first (101), a second (102) and a third (103) fluidic channel intersecting at a common junction (105). The first fluidic channel is connectable to a coating fluid reservoir and the third fluidic channel is connectable to a sample fluid reservoir. The fluidic device (100) further comprises a fluid control means (111) configured for creating a fluidic flow path for a coating fluid at the common junction (105) such that, when coating, a coating fluid propagates from the first (101) to the second (102) fluidic channel via the common junction (105) without propagating into the third (103) fluidic channel. A corresponding method for coating and for sensing also has been disclosed.
摘要:
The present disclosure relates to, inter alia, an easy-to- operate, fully closed component, which can be part of an instrument, for purification of biomolecules from biological samples, and subsequent transfer, and testing of the biomolecules, as well as an instrument comprising the component, and a method for using the component.