公开(公告)号：WO2023091118A1

公开(公告)日：2023-05-25

申请号：PCT/TR2022/051313

申请日：2022-11-18

申请人： EGE ÜNİVERSİTESİ

发明人： ERDEM GÜRSAN, Kadriye Arzum ,  ŞENTÜRK, Muhammed Hüseyin ,  YILDIZ, Esma ,  MARAL, Meltem

IPC分类号： G01N27/327

摘要： The invention relates to an enzymatic-based method by using amperometry technique for sensitive and selective determination of the SARS-CoV-2 S1 protein for the diagnosis of COVID-19 disease, an immunosensor, and a method of preparation thereof.

公开(公告)号：WO2022146314A1

公开(公告)日：2022-07-07

申请号：PCT/TR2021/051028

申请日：2021-10-08

申请人： EGE ÜNİVERSİTESİ

发明人： DÖŞKAYA, Mert ,  ELALDI, Nazif ,  İZ, Sultan Gülçe ,  CAN, Hüseyin ,  KARAKAVUK, Muhammet ,  DEĞİRMENCİ DÖŞKAYA, Aysu ,  GÜRÜZ, Adnan Yüksel ,  ÖZDARENDELİ, Aykut ,  FELGNER, Philip Louis ,  DAVIES, Huw ,  GÜL, Aytül

IPC分类号： C12N15/00 ,  C12N15/09 ,  G01N33/53 ,  G01N33/569

摘要： The present invention relates to methods of diagnosis or detection of Crimean Congo Hemorrhagic Fever virus comprising determining the presence of at least one nucleic acid or protein of said virus or antibodies thereto, in a biological sample. The invention also relates to the various diagnostic agents or compositions derived from the viral nucleic acids or proteins, in particular nucleic acid primers and probes, antigens and antibodies, and their use for the diagnosis of Crimean Congo Hemorrhagic Fever virus infection and associated disease. The final product is a "a novel ELISA" (Rec-ELISA) using recombinant full-length S-segment and Mucin-like domain of M-segment of CCHFV that detects anti-CCHFV IgG antibody with high sensitivity and specificity.

公开(公告)号：WO2020112066A1

公开(公告)日：2020-06-04

申请号：PCT/TR2019/051000

申请日：2019-11-26

申请人： EGE ÜNİVERSİTESİ REKTÖRLÜĞÜ

发明人： KÖYLÜ, Murat ,  BİLGE, Metin ,  ÖZKAN, Ertuğrul

IPC分类号： A61B8/08 ,  A61B5/00 ,  A61B5/11 ,  G16H50/30

摘要： The invention is related to a radiotherapy respiration tracking system.

公开(公告)号：WO2023091119A1

公开(公告)日：2023-05-25

申请号：PCT/TR2022/051315

申请日：2022-11-18

申请人： EGE ÜNİVERSİTESİ

发明人： ERDEM GÜRSAN, Kadriye Arzum ,  ŞENTÜRK, Muhammed Hüseyin ,  YILDIZ, Esma ,  MARAL, Meltem

IPC分类号： G01N27/02

摘要： The invention relates to a method based on the electrochemical impedance spectroscopy method for the sensitive and selective determination of SARS-CoV-2 S1 protein for the diagnosis of COVID-19 disease, an impedimetric immunosensor, and a method for preparation thereof.

公开(公告)号：WO2022186807A2

公开(公告)日：2022-09-09

申请号：PCT/TR2022/050190

申请日：2022-03-03

申请人： İZMİR YÜKSEK TEKNOLOJİ ENSTİTÜSÜ ,  EGE ÜNİVERSİTESİ

发明人： YILDIZ, Ahu Arslan ,  SÖZMEN, Alper Baran ,  SÖZMEN, Eser Yildirim

IPC分类号： G01N21/78 ,  G01N33/68 ,  C12Q1/527

摘要： The invention is based on a UV-Vis spectrophotometric method, which is developed to diagnose phenylketonuria (PKU). The method is able to measure the amount of phenylalanine in blood samples in short periods of time with ease to follow-up. In the method of the invention, a yellow colored complex is formed with trans-cinnamic acid and FeCl3 solution, and the absorbance value of this complex is measured with a spectrophotometric device.

公开(公告)号：WO2022119539A1

公开(公告)日：2022-06-09

申请号：PCT/TR2021/051321

申请日：2021-12-01

申请人： EGE ÜNİVERSİTESİ

发明人： ŞANLIER, Şenay ,  AK DEMİROZ, Güliz ,  KARADAĞ, Belgüzar ,  KARAKAYALI, Tuğba

IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K31/12 ,  A61P35/00

摘要： The invention relates to liposomes containing doxorubicin (DOX), carmustine (BCNU), and curcumin (CUR) developed for use in the treatment of glioblastoma.

公开(公告)号：WO2020072019A2

公开(公告)日：2020-04-09

申请号：PCT/TR2019/050810

申请日：2019-09-30

申请人： EGE ÜNİVERSİTESİ

发明人： BAYRAKTAR, Oğuz ,  YAHŞI, Yasemin ,  KÖSE, Merve Deniz

摘要： The invention relates to a dual layer biopolymer-based nano/micro carrier system comprising a core layer which can protect at a maximum level the stable structure of the natural compound formed of an eggshell membrane protein prepared under certain conditions and a shell layer formed of silk protein, that allows the stable and controlled release of a natural compound in the core portion and a method of production by changing and optimizing some physical features of the compound of this system.

公开(公告)号：WO2022132102A1

公开(公告)日：2022-06-23

申请号：PCT/TR2021/051411

申请日：2021-12-15

申请人： EGE ÜNİVERSİTESİ

发明人： YILDIRIM, Yeliz ,  VARDAR, Özge

IPC分类号： A61K9/51 ,  A61K31/722 ,  A61K31/734

摘要： The invention relates to the synthesis of cafestol -loaded chitosan and alginate biopolymer nanoparticles that have been synthesized for use in diabetes and cancer diseases and in-vitro release studies of which have been conducted.

公开(公告)号：WO2022125031A1

公开(公告)日：2022-06-16

申请号：PCT/TR2021/051205

申请日：2021-11-15

申请人： EGE ÜNİVERSİTESİ [TR]/[TR]

发明人： ŞANLIER, Şenay ,  AK DEMİROZ, Güliz ,  ÜNAL, Ayşe

IPC分类号： A61K47/36 ,  A61P35/00 ,  A61K31/7068 ,  C07H19/06

摘要： The invention relates to trimethyl chitosan nanoparticles containing magnetic -targeted gemcitabine developed for use in the treatment of lung cancer.

公开(公告)号：WO2022115080A1

公开(公告)日：2022-06-02

申请号：PCT/TR2021/051236

申请日：2021-11-19

申请人： EGE ÜNİVERSİTESİ

发明人： ERDEM GÜRSAN, Kadriye Arzum ,  YILDIZ, Esma

IPC分类号： G01N27/30 ,  C01B32/20 ,  C01B33/40

摘要： The invention is related to a disposable carbon-based electrode developed by modifying the surface with nanocomposite formed by halloysite nanoclay (HNT) and ionic liquid (IL).