公开(公告)号：WO2017112678A1

公开(公告)日：2017-06-29

申请号：PCT/US2016/067795

申请日：2016-12-20

Applicant: MCLEOD, Rima ,  MCPHILLIE, Martin ,  FISHWICK, Colin, W.g. ,  LORENZI, Hernan, Alejandro ,  WANG, Kai ,  KIM, Taek-kyun ,  ZHOU, Yong ,  HOOD, Leroy, E. ,  ZHOU, Ying ,  EL BISSATI, Kamal ,  GORDON, James ,  HICKMAN, Mark ,  LI, QiGui ,  ROBERTS, Craig

Inventor： MCLEOD, Rima ,  MCPHILLIE, Martin ,  FISHWICK, Colin, W.g. ,  LORENZI, Hernan, Alejandro ,  WANG, Kai ,  KIM, Taek-kyun ,  ZHOU, Yong ,  HOOD, Leroy, E. ,  ZHOU, Ying ,  EL BISSATI, Kamal ,  GORDON, James ,  HICKMAN, Mark ,  LI, QiGui ,  ROBERTS, Craig

IPC: C07D215/233 ,  C07D401/04 ,  C07D401/10 ,  C07D487/04 ,  C07D239/96 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/517 ,  A61K31/519 ,  A61P33/02

CPC classification number: A61K31/47 ,  A61K31/4709 ,  A61K31/517 ,  A61K31/519 ,  C07D215/233 ,  C07D217/02 ,  C07D239/96 ,  C07D401/04 ,  C07D401/10 ,  C07D487/04

Abstract: Disclosed herein; are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to teat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.

Abstract translation:

在此公开; 是用于治疗apicomplexan寄生虫相关病症的新化合物，它们的使用方法; 休眠寄生虫表型的细胞系和非人动物模型以及它们用于鉴定用于乳头状复合寄生虫相关病症的新药物的方法，以及鉴定由于寄生虫及其对治疗的响应而引起的疾病的生物标记。

公开(公告)号：WO2017184456A1

公开(公告)日：2017-10-26

申请号：PCT/US2017/027675

申请日：2017-04-14

Applicant: MCLEOD, Rima ,  EL BISSATI, Kamal ,  ZHOU, Ying ,  ALEXANDER, Jeff ,  VANG, Lo ,  REED, Steve ,  PAULILLO, Sara, M. ,  RAMAN, Senthil, K. ,  BURKHARD, Peter ,  MELO, Mariane ,  IRVINE, Darrel ,  WEISS, Ron ,  ZHANG, Yuan ,  SETTE, Alessandro ,  SIDNEY, John ,  LIVINGSTON, Brian, D. ,  LORENZI, Hernan

Inventor： MCLEOD, Rima ,  EL BISSATI, Kamal ,  ZHOU, Ying ,  ALEXANDER, Jeff ,  VANG, Lo ,  REED, Steve ,  PAULILLO, Sara, M. ,  RAMAN, Senthil, K. ,  BURKHARD, Peter ,  MELO, Mariane ,  IRVINE, Darrel ,  WEISS, Ron ,  ZHANG, Yuan ,  SETTE, Alessandro ,  SIDNEY, John ,  LIVINGSTON, Brian, D. ,  LORENZI, Hernan

IPC: A61K31/7088 ,  A61K38/17 ,  A61K39/012 ,  A61P33/02 ,  A61P37/04 ,  C12N15/11 ,  C12N15/12 ,  C12N15/63

Abstract: Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.

Abstract translation: 本文公开了编码多表位多肽及其组装体的多核苷酸，以及它们用于治疗或限制弓形虫感染的用途。