公开(公告)号：WO2021155612A

公开(公告)日：2021-08-12

申请号：PCT/CN2020/074569

申请日：2020-02-09

申请人： MERCK SHARP & DOHME CORP. [US]/[US] ,  THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH [AU]/[AU] ,  MSD R&D (CHINA) CO., LTD. [CN]/[CN] ,  De Lera Ruiz, Manuel [US]/[US] (US) ,  FAVUZZA, Paola [IT]/[AU] (US) ,  GUO, Zhuyan [US]/[US] (US) ,  HU, Bin [CN]/[CN] (US) ,  LEI, Zhiyu [CN]/[CN] (US) ,  MCCAULEY, John A. [US]/[US] (US) ,  OLSEN, David B. [US]/[US] (US) ,  SLEEBS, Brad [AU]/[AU] (US) ,  TRIGLIA, Tony [AU]/[AU] (US) ,  ZHAN, Dongmei [CN]/[CN] (US) ,  ZHAO, Lianyun [US]/[CN] (US) ,  Kelly III, Michael J. (US)

发明人： De Lera Ruiz, Manuel ,  FAVUZZA, Paola ,  GUO, Zhuyan ,  HU, Bin ,  LEI, Zhiyu ,  MCCAULEY, John A. ,  OLSEN, David B. ,  SLEEBS, Brad ,  TRIGLIA, Tony ,  ZHAN, Dongmei ,  ZHAO, Lianyun ,  Kelly III, Michael J.

IPC分类号： C07D401/10 ,  C07D403/10 ,  C07D417/10 ,  C07D471/04 ,  A61K31/513 ,  A61P33/06

摘要： Provided are methods of treating malaria comprising administration of compounds of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. Privided are uses of the compounds of Formula (I), as defined herein, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.

公开(公告)号：WO2021155791A1

公开(公告)日：2021-08-12

申请号：PCT/CN2021/074928

申请日：2021-02-02

申请人： MERCK SHARP & DOHME CORP. ,  THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH ,  MSD R&D (CHINA) CO., LTD. ,  DE LERA RUIZ, Manuel ,  FAVUZZA, Paola ,  GUO, Zhuyan ,  HU, Bin ,  KELLY III, Michael J. ,  LEI, Zhiyu ,  MCCAULEY, John A. ,  OLSEN, David B. ,  SLEEBS, Brad ,  TRIGLIA, Tony ,  ZHAN, Dongmei ,  ZHAO, Lianyun

发明人： DE LERA RUIZ, Manuel ,  FAVUZZA, Paola ,  GUO, Zhuyan ,  HU, Bin ,  KELLY III, Michael J. ,  LEI, Zhiyu ,  MCCAULEY, John A. ,  OLSEN, David B. ,  SLEEBS, Brad ,  TRIGLIA, Tony ,  ZHAN, Dongmei ,  ZHAO, Lianyun

IPC分类号： C07D401/10 ,  C07D403/10 ,  C07D417/10 ,  C07D471/04 ,  A61K31/513 ,  A61P33/06

摘要： Provided are methods of treating malaria comprising administration of compounds of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. Also provided are uses of the compounds of Formula (I), as defined herein, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.