公开(公告)号：WO2017165619A1

公开(公告)日：2017-09-28

申请号：PCT/US2017/023764

申请日：2017-03-23

申请人： FIMBRION THERAPEUTICS, INC.

发明人： JANETKA, James, W. ,  MYDOCK-MCGRANE, Laurel

IPC分类号： A61K31/7034 ,  C07H15/26 ,  C07H15/203

摘要： The present invention relates to mannoside derivative compounds useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract infection.

摘要翻译： 本发明涉及可用作FimH抑制剂的甘露糖苷衍生物化合物和用于治疗或预防尿路感染的方法。

公开(公告)号：WO2022236182A1

公开(公告)日：2022-11-10

申请号：PCT/US2022/028372

申请日：2022-05-09

申请人： FIMBRION THERAPEUTICS, INC. ,  WASHINGTON UNIVERSITY ,  SAINT LOUIS UNIVERSITY

发明人： JANETKA, James ,  MYDOCK-MCGRANE, Laurel ,  HAYES, Keith ,  MEYERS J., Marvin

IPC分类号： C07D495/04 ,  A61K31/505 ,  A61K31/519 ,  C07D495/02

摘要： The present disclosure relates to various compounds and compositions which are useful for the treatment of tuberculosis and other diseases such as infections caused by Mycobacterium tuberculosis. The present disclosure also relates to various methods of using these compounds and compositions to treat tuberculosis and other diseases such as infections caused by Mycobacterium tuberculosis. Further, the present disclosure relates to processes of preparing these compounds and compositions.

公开(公告)号：WO2020012336A1

公开(公告)日：2020-01-16

申请号：PCT/IB2019/055806

申请日：2019-07-08

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED ,  FIMBRION THERAPEUTICS, INC.

发明人： BISHOP, Michael Joseph ,  COLANDREA, Vincent J. ,  LI, Yuehu ,  STEWART, Eugene L. ,  STRAMBEANU, Iulia ,  WIDDOWSON, Katherine Louisa ,  JANETKA, James Walter ,  MCGRANE, Laurel Kathryn

IPC分类号： C07D309/10 ,  A61P31/04 ,  A61K31/7034

摘要： Disclosed herein are new C-mannoside compounds and compositions and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment diseases such as urinary tract infection.

公开(公告)号：WO2020254369A1

公开(公告)日：2020-12-24

申请号：PCT/EP2020/066707

申请日：2020-06-17

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED ,  FIMBRION THERAPEUTICS INC

发明人： BISHOP, Michael Joseph ,  JANETKA, James Walter ,  MCGRANE, Laurel Kathryn ,  WIDDOWSON, Katherine Louisa

IPC分类号： C07H15/203 ,  C07H15/26 ,  A61K31/7034 ,  A61K31/706 ,  A61P13/02 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00

摘要： Disclosed herein are new O-biphenyl- and O-phenylheteroaryl- mannoside compounds and compositions and their application as pharmaceuticals for use in the treatment of human disease. Methods of inhibition of FimH activity in human subjects are also provided for the treatment of diseases such as urinary tract infection.

公开(公告)号：WO2017156508A1

公开(公告)日：2017-09-14

申请号：PCT/US2017/021983

申请日：2017-03-11

申请人： FIMBRION THERAPEUTICS, INC.

发明人： JANETKA, James, W. ,  MYDOCK-MCGRANE, Laurel

IPC分类号： A61K31/7034 ,  A61K31/7048 ,  A61K31/7056

摘要： The present invention relates to mannoside derivative compounds useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract infection.

摘要翻译： 本发明涉及可用作FimH抑制剂的甘露糖苷衍生物化合物和用于治疗或预防尿路感染的方法。