公开(公告)号：WO2019246119A1

公开(公告)日：2019-12-26

申请号：PCT/US2019/037761

申请日：2019-06-18

申请人： THE GEORGE WASHINGTON UNIVERSITY A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION ,  WASHINGTON UNIVERSITY

发明人： DOWD, Cynthia ,  ODOM JOHN, Audrey ,  EDWARDS, Rachel ,  HEIDEL, Kenneth M. ,  WANG, Xu ,  CHOFOR, Rene

IPC分类号： A61P31/04 ,  C07C239/08 ,  C07C239/18

摘要： The present disclosure provides method of treating or preventing a microbial infection caused by a prokaryotic pathogen in a subject, the method comprising administering a compound of Formula (I) as set forth in the specification. In one embodiment, the prokaryotic pathogen belongs to the genus Staphyloccoccus .

公开(公告)号：WO2019005982A1

公开(公告)日：2019-01-03

申请号：PCT/US2018/039777

申请日：2018-06-27

申请人： THE GEORGE WASHINGTON UNIVERSITY ,  WASHINGTON UNIVERSITY IN ST. LOUIS ,  GEORGE MASON UNIVERSITY ,  SAINT LOUIS UNIVERSITY

发明人： DOWD, Cynthia ,  WANG, Xu ,  BROTHERS, Robert Carl ,  JOHN, Audrey Ragan Odom ,  EDWARDS, Rachel ,  MEYERS, Marvin ,  ARNETT, Stacy ,  COUCH, Robin ,  HEIDEL, Kenneth

IPC分类号： A61K31/66 ,  A61K31/662 ,  A61K33/42 ,  C07F9/28 ,  C07F9/38 ,  C07F9/40

摘要： The present disclosure relates to novel compounds, pharmaceutical compositions, and methods for treating or preventing microbial infection caused by parasites or bacteria, such as Plasmodium falciparum or related Plasmodium parasite species and Mycobacterium tuberculosis or related Mycobacterium bacteria species. The compounds are α,β-unsaturated analogs of fosmidomycin and can inhibit deoxyxylulose phosphate reductoisomerase (Dxr) in many microbes, such as P. falciparum .

公开(公告)号：WO2017127805A1

公开(公告)日：2017-07-27

申请号：PCT/US2017/014564

申请日：2017-01-23

申请人： THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION ,  WASHINGTON UNIVERSITY IN ST. LOUIS

发明人： DOWD, Cynthia ,  ODOM, Audrey ,  EDWARDS, Rachel ,  BROTHERS, Robert

IPC分类号： A61K31/66 ,  A61K31/357 ,  A61K31/65

CPC分类号： A61K31/357 ,  A61K31/122 ,  A61K31/137 ,  A61K31/155 ,  A61K31/366 ,  A61K31/437 ,  A61K31/4706 ,  A61K31/49 ,  A61K31/496 ,  A61K31/519 ,  A61K31/65 ,  A61K31/683 ,  A61K31/7056 ,  A61K45/06 ,  Y02A50/411 ,  A61K2300/00

摘要： A pharmaceutical composition includes a small molecule and a pharmaceutically acceptable excipient. The small molecule interacts with a deoxyxylulose phosphate reductoisomerase (Dxr). A method for treating or preventing a microbial infection in a subject in need thereof includes administering the pharmaceutical composition. A method for inhibiting the growth of a eukaryotic pathogen includes contacting the eukaryotic pathogen with an effective amount of the pharmaceutical composition.

摘要翻译： 药物组合物包含小分子和药学上可接受的赋形剂。 小分子与脱氧木酮糖磷酸还原异构酶（Dxr）相互作用。 用于治疗或预防有需要的受试者中的微生物感染的方法包括施用所述药物组合物。 用于抑制真核病原体生长的方法包括使真核病原体与有效量的药物组合物接触。

公开(公告)号：WO2023092144A1

公开(公告)日：2023-05-25

申请号：PCT/US2022/080337

申请日：2022-11-22

申请人： THE GEORGE WASHINGTON UNIVERSITY ,  MISSISSIPPI STATE UNIVERSITY

发明人： MILLAR, Richard Clive ,  MLSNA, Todd ,  WARREN, Sita

IPC分类号： B01J20/30 ,  C05B17/00 ,  C05D9/00 ,  C05F11/08 ,  C05G3/80

摘要： The present disclosure relates to improved processes for preparing modified lignite by reacting raw lignite with a source of magnesium (Mg2+) ions and a source of calcium (Ca2+) ions, washing the modified lignite (e.g., with water), drying, and pyrolyzing the treated lignite, and to the use of such products for phosphorous remediation.

公开(公告)号：WO2023081733A1

公开(公告)日：2023-05-11

申请号：PCT/US2022/079187

申请日：2022-11-02

申请人： WASHINGTON UNIVERSITY

发明人： DESELM, Carl ,  NAMEN, Shelby

IPC分类号： C07K14/705 ,  A61K35/17 ,  A61P35/00 ,  C07K16/28 ,  C12N5/0783

摘要： Among the various aspects of the present disclosure is the provision of compositions and methods of making modified chimeric antigen receptor dendritic cells (CAR-DCs) and methods of use thereof. CAR-DCs can be used for the treatment of tumors and cancers, particularly solid tumors (as well as liquid tumors, blood cancer, and metastatic cancer).

公开(公告)号：WO2023049762A1

公开(公告)日：2023-03-30

申请号：PCT/US2022/076800

申请日：2022-09-21

申请人： WASHINGTON UNIVERSITY ,  UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： AMARASINGHE, Gaya ,  GANAIE, Safder ,  LEUNG, Daisy ,  VIRGIN, Herbert ,  HARTMAN, Amy

IPC分类号： A61K38/17 ,  A61P31/14 ,  C07K14/705

摘要： The present disclosure relates to compositions and methods for treating or preventing a viral infection. The present disclosure also provide compositions and method for improving transfer of a therapeutic or imaging agent transfer across the blood-brain-barrier. In addition the present disclosure provides compositions and methods for treating various central nervous system disease and disorders including, for example, tauopathies.

公开(公告)号：WO2023039526A2

公开(公告)日：2023-03-16

申请号：PCT/US2022/076205

申请日：2022-09-09

申请人： THE GEORGE WASHINGTON UNIVERSITY

发明人： MCCAFREY, Timothy, A.

IPC分类号： C12Q1/00

摘要： The present technology detects immune cell activation. In certain embodiments, the system has a polymer block with a reaction chamber having an optically clear light path and fluidic connections to a device having a microcontroller in communication with electromagnets, air pumps, valves, an LED light source, and a photosensor. The polymer block is able to receive a blood sample in media comprising antibody coated beads. With the block placed in the device, the electromagnets facilitate magnetic capture of a complex between specific cells in the blood sample and the antibody coated beads. The pump and valves are coordinated with the electromagnet such that the captured cells can be retained in the block while unwanted cells and proteins are washed away. After capture of the cells, the cells are lysed in the presence of a cleavable substrate. The LED transmits light through the reaction chamber in the polymer block, and the photosensor detects light transmittance through the fluid containing the lysed cells and the cleavable substrate. The cleavage of an elastase substrate by the lysed cells generates a reaction product that absorbs light of specific wavelengths, and thus the decrease in light transmittance over time is indicative of elevated elastase activity and immune cell activation in the blood sample.

公开(公告)号：WO2022236182A1

公开(公告)日：2022-11-10

申请号：PCT/US2022/028372

申请日：2022-05-09

申请人： FIMBRION THERAPEUTICS, INC. ,  WASHINGTON UNIVERSITY ,  SAINT LOUIS UNIVERSITY

发明人： JANETKA, James ,  MYDOCK-MCGRANE, Laurel ,  HAYES, Keith ,  MEYERS J., Marvin

IPC分类号： C07D495/04 ,  A61K31/505 ,  A61K31/519 ,  C07D495/02

摘要： The present disclosure relates to various compounds and compositions which are useful for the treatment of tuberculosis and other diseases such as infections caused by Mycobacterium tuberculosis. The present disclosure also relates to various methods of using these compounds and compositions to treat tuberculosis and other diseases such as infections caused by Mycobacterium tuberculosis. Further, the present disclosure relates to processes of preparing these compounds and compositions.

公开(公告)号：WO2022226038A1

公开(公告)日：2022-10-27

申请号：PCT/US2022/025501

申请日：2022-04-20

申请人： THE GEORGE WASHINGTON UNIVERSITY

发明人： CHUNG, Inhee

IPC分类号： G01N33/574 ,  G01N33/68 ,  C12Q1/6886 ,  A61B5/00

摘要： Embodiments of the instant disclosure relate to novel methods and compositions for distinguishing high-grade ductal carcinoma in situ (DCIS) from low-grade DCIS in a breast tissue. Other embodiments of the instant disclosure provide for methods of administering one or more appropriate breast cancer treatment regimens to a subject diagnosed with high-risk DCIS.

公开(公告)号：WO2022212769A1

公开(公告)日：2022-10-06

申请号：PCT/US2022/022926

申请日：2022-03-31

申请人： WASHINGTON UNIVERSITY

发明人： TU, Zhude ,  QIU, Lin ,  GU, Jiwei ,  YU, Yanbo ,  GROPLER, Robert

IPC分类号： A61K31/395 ,  A61K31/41 ,  A61K31/4245 ,  C07D271/00 ,  C07D271/02 ,  C07D271/06

摘要： The present disclosure generally relates to compounds and compositions for use in imaging agents, methods of use for monitoring and/or treating conditions or diseases related to sphingosine-1-phosphate (S1P) signaling, and processes for preparing these compositions and compounds.