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公开(公告)号：WO2013149111A2
公开(公告)日：2013-10-03
申请号：PCT/US2013/034543
申请日：2013-03-29
Applicant: NOVIMMUNE S.A. , ROUSSEAU, Francois , LOYAU, Jérémy , FISCHER, Nicolas , ELSON, Greg , KOSCO-VILBOIS, Marie
Inventor： ROUSSEAU, Francois , LOYAU, Jérémy , FISCHER, Nicolas , ELSON, Greg , KOSCO-VILBOIS, Marie
IPC: C07K16/28
CPC classification number: C07K16/2896 , C07K16/2866 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92
Abstract: Disclosed are antibodies that specifically bind Toll-like Receptor 4 (TLR-4), and to methods of using the anti-TLR4 antibodies as therapeutics and diagnostic agents.
Abstract translation: 公开了特异性结合Toll样受体4（TLR-4）的抗体，以及使用抗TLR4抗体作为治疗剂和诊断剂的方法。
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2.发明申请SYNTHETIC POLYPEPTIDE LIBRARIES AND METHODS FOR GENERATING NATURALLY DIVERSIFIED POLYPEPTIDE VARIANTS 审中-公开合成多肽图书馆和产生自然多样性多肽变体的方法
公开(公告)号：WO2011084255A2
公开(公告)日：2011-07-14
申请号：PCT/US2010/057780
申请日：2010-11-23
Applicant: NOVIMMUNE S.A. , FISCHER, Nicolas , KOSCO-VILBOIS, Marie , RAVN, Ulla , GUENEAU, Franck , VENET-BONNOT, Sophie
Inventor： FISCHER, Nicolas , KOSCO-VILBOIS, Marie , RAVN, Ulla , GUENEAU, Franck , VENET-BONNOT, Sophie
CPC classification number: C12N15/70 , C07K16/005 , C07K16/249 , C07K16/42 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N15/1034
Abstract: The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence.
Abstract translation: 本发明提供了用于产生编码同源多肽的DNA序列文库的组合物和方法，以及文库鉴定天然多样化多肽变体的用途。 本发明还提供用于产生合成抗体片段的组合物的组合物和方法，其中一个或几个互补决定区域（CDR）由从天然来源捕获的相应CDR的集合代替。 本发明还提供了通过插入合成或天然来源的多样化序列来多样化多肽的组合物和方法，而不需要修饰原始多肽编码序列。
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公开(公告)号：WO2005118635A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/019922
申请日：2005-06-03
Applicant: NOVIMMUNE S.A. , MACH, Bernard , DEAN, Yann , KOSCO-VILBOIS, Marie , ELSON, Greg, Christopher, Andrew , FISCHER, Nicolas , LEGER, Olivier
Inventor： MACH, Bernard , DEAN, Yann , KOSCO-VILBOIS, Marie , ELSON, Greg, Christopher, Andrew , FISCHER, Nicolas , LEGER, Olivier
IPC: C07K14/47
CPC classification number: C07K16/2809 , A61K39/3955 , A61K45/06 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/74
Abstract: The present invention is related to antibodies directed to the antigen CD3 and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies directed to CD3. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR’s), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
Abstract translation: 本发明涉及针对抗原CD3的抗体和这种抗体的用途。 特别地，本发明提供了完全针对CD3的人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是包含重链和轻链免疫球蛋白分子的序列，特别是对应于跨越框架区和/或互补决定区的连续重链和轻链序列的序列（CDR ），特别是FR1至FR4或CDR1至CDR3。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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4.发明申请
公开(公告)号：WO2013136186A3
公开(公告)日：2014-01-23
申请号：PCT/IB2013000902
申请日：2013-03-13
Applicant: NOVIMMUNE SA , FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANCOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
Inventor： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANCOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
CPC classification number: C07K16/468 , C07K16/244 , C07K16/2809 , C07K2317/31
Abstract: The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).
Abstract translation: 本发明涉及具有重链异源二聚体的抗原结合蛋白或抗体，即两条免疫球蛋白重链之间有差异的至少一个或两个氨基酸，其允许基于差异亲和力分离抗原结合蛋白 的免疫球蛋白重链和修饰/突变的免疫球蛋白重链朝向亲和试剂。 本发明还涉及包含双特异性抗体的抗原结合蛋白，其具有相对于亲和试剂具有不同亲和力的IgG CH1区域，其允许通过IgG区域与亲和试剂的差异结合快速分离。
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公开(公告)号：WO2013088259A2
公开(公告)日：2013-06-20
申请号：PCT/IB2012/003028
申请日：2012-10-19
Applicant: NOVIMMUNE S.A. , ELSON, Greg , FOUQUE, Nicolas , DEPOISIER, Jean-François , FISCHER, Nicolas , MAGISTRELLI, Giovanni
Inventor： ELSON, Greg , FOUQUE, Nicolas , DEPOISIER, Jean-François , FISCHER, Nicolas , MAGISTRELLI, Giovanni
IPC: A61K39/00
CPC classification number: C07K16/00 , C07K16/248 , C07K16/249 , C07K16/2866 , C07K16/468 , C07K2317/32 , C07K2317/52
Abstract: The invention provides methods of purifying antibodies using various antibody- specific purification media to rapidly and efficiently separate mixtures of antibodies, antibody fragments and/or antibody components to isolate a desired antibody product from the mixture. The invention relates to the purification of bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, e.g., antibodies composed of a single heavy chain and two different light chains, one containing Kappa constant domain and the other a Lambda constant domain, including antibodies of different specificities that share a common heavy chain. The invention also provides the methods of efficiently purifying intact antibodies by separating the intact antibody from non-intact antibodies including free light chains.
Abstract translation: 本发明提供使用各种抗体特异性纯化介质纯化抗体的方法，以快速且有效地分离抗体，抗体片段和/或抗体组分的混合物，以从混合物中分离所需的抗体产物。 本发明涉及对免疫球蛋白分子的每个结合位点具有不同特异性的双特异性单克隆抗体的纯化，例如由单个重链和两个不同轻链组成的抗体，一个含有κ恒定结构域，另一个包含λ恒定结构域 ，包括具有共同重链的不同特异性的抗体。 本发明还提供了通过将完整抗体与包括游离轻链在内的不完整抗体分离来有效纯化完整抗体的方法。
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Patent Agency Ranking
公开(公告)号：WO2012023053A3
公开(公告)日：2012-05-24
申请号：PCT/IB2011002664
申请日：2011-08-16
Applicant: NOVIMMUNE SA , FISCHER NICOLAS , MAGISTRELLI GIOVANNI , GUENEAU FRANCK , RAVN ULLA , ELSON GREG
Inventor： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , GUENEAU FRANCK , RAVN ULLA , ELSON GREG
CPC classification number: C07K16/468 , C07K16/005 , C07K16/248 , C07K16/249 , C07K16/2866 , C07K2317/31 , C07K2317/32 , C07K2317/622 , C07K2317/92 , C12N15/1037 , C12N15/1075
Abstract: The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other of a Lambda constant domain. The invention provides methods for the isolation of antibodies of different specificities but sharing a common heavy chain. The invention also provides methods for the controlled co-expression of two light chains and a single heavy chain leading to the assembly of monospecific and bispecific antibodies. The invention provides a mean of producing a fully human bispecific and bivalent antibody that is unaltered in sequence and does not involve the use of linkers or other non-human sequences, as well as antibody mixtures of two monospecific antibodies and one bispecific antibody. The invention also provides the means of efficiently purifying the bispecific antibody.
Abstract translation: 本发明提供对免疫球蛋白分子的每个结合位点携带不同特异性的新型双特异性单克隆抗体以及用于产生对免疫球蛋白分子的每个结合位点具有不同特异性的新型双特异性单克隆抗体的方法。 抗体由单个重链和两个不同的轻链组成，一个含有κ恒定结构域，另一个是λ恒定结构域。 本发明提供了分离不同特异性但共享共同重链的抗体的方法。 本发明还提供了两个轻链和单个重链的受控共表达的方法，导致单特异性和双特异性抗体的组装。 本发明提供了产生完全人双特异性和二价抗体的平均值，其依次不变，不涉及使用接头或其它非人序列，以及两种单特异性抗体和一种双特异性抗体的抗体混合物。 本发明还提供有效纯化双特异性抗体的方法。
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公开(公告)号：WO2009054873A2
公开(公告)日：2009-04-30
申请号：PCT/US2008/009382
申请日：2008-08-04
Applicant: NOVIMMUNE S.A. , FISCHER, Nicolas , KOSCO-VILBOIS, Marie , MACH, Francois
Inventor： FISCHER, Nicolas , KOSCO-VILBOIS, Marie , MACH, Francois
IPC: C07K2/00 , C07H21/00 , C07K16/18 , A61K39/395
CPC classification number: C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The invention relates to fully human monoclonal antibodies, and fragments thereof, that bind to the chemokine Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES, CCL5), thereby modulating the interaction between RANTES and one of more of its receptors, such as, e.g., CCR1, CCR3, CCR4 and CCR5, and/or modulating the biological activities of RANTES. The invention also relates to the use of these or any anti-RANTES antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder.
Abstract translation: 本发明涉及完全人单克隆抗体及其片段，其结合活化时调节的趋化因子，表达正常T细胞和分泌型（RANTES，CCL5），从而调节RANTES与其多个受体之一的相互作用， 例如CCR1，CCR3，CCR4和CCR5，和/或调节RANTES的生物学活性。 本发明还涉及这些或任何抗RANTES抗体在预防或治疗免疫相关疾病以及改善与免疫相关病症相关的一种或多种症状中的用途。
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公开(公告)号：WO2005118635A3
公开(公告)日：2006-06-15
申请号：PCT/US2005019922
申请日：2005-06-03
Applicant: NOVIMMUNE SA , MACH BERNARD , DEAN YANN , KOSCO-VILBOIS MARIE , ELSON GREG CHRISTOPHER ANDREW , FISCHER NICOLAS , LEGER OLIVIER
Inventor： MACH BERNARD , DEAN YANN , KOSCO-VILBOIS MARIE , ELSON GREG CHRISTOPHER ANDREW , FISCHER NICOLAS , LEGER OLIVIER
CPC classification number: C07K16/2809 , A61K39/3955 , A61K45/06 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/74
Abstract: The present invention is related to antibodies directed to the antigen CD3 and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies directed to CD3. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
Abstract translation: 本发明涉及针对抗原CD3的抗体和这种抗体的用途。 特别地，本发明提供了完全针对CD3的人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是包含重链和轻链免疫球蛋白分子的序列，特别是对应于跨越框架区和/或互补决定区的连续重链和轻链序列的序列（CDR ），特别是FR1至FR4或CDR1至CDR3。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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公开(公告)号：WO2013088259A3
公开(公告)日：2013-11-14
申请号：PCT/IB2012003028
申请日：2012-10-19
Applicant: NOVIMMUNE SA , ELSON GREG , FOUQUE NICOLAS , DEPOISIER JEAN-FRANCOIS , FISCHER NICOLAS , MAGISTRELLI GIOVANNI
Inventor： ELSON GREG , FOUQUE NICOLAS , DEPOISIER JEAN-FRANCOIS , FISCHER NICOLAS , MAGISTRELLI GIOVANNI
CPC classification number: C07K16/00 , C07K16/248 , C07K16/249 , C07K16/2866 , C07K16/468 , C07K2317/32 , C07K2317/52
Abstract: The invention provides methods of purifying antibodies using various antibody- specific purification media to rapidly and efficiently separate mixtures of antibodies, antibody fragments and/or antibody components to isolate a desired antibody product from the mixture. The invention relates to the purification of bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, e.g., antibodies composed of a single heavy chain and two different light chains, one containing Kappa constant domain and the other a Lambda constant domain, including antibodies of different specificities that share a common heavy chain. The invention also provides the methods of efficiently purifying intact antibodies by separating the intact antibody from non-intact antibodies including free light chains.
Abstract translation: 本发明提供了使用各种抗体特异性纯化介质来纯化抗体以快速且有效地分离抗体，抗体片段和/或抗体组分的混合物以从混合物中分离出所需抗体产物的方法。 本发明涉及纯化对免疫球蛋白分子的每个结合位点具有不同特异性的双特异性单克隆抗体，例如由单一重链和两个不同轻链组成的抗体，一个含有κ恒定结构域，另一个含有λ恒定结构域 包括具有共同重链的不同特异性的抗体。 本发明还提供了通过将完整抗体与包括游离轻链的非完整抗体分开来有效纯化完整抗体的方法。
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10.发明申请
公开(公告)号：WO2010135558A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035619
申请日：2010-05-20
Applicant: NOVIMMUNE S.A. , FISCHER, Nicolas , KOSCO-VILBOIS, Marie , RAVN, Ulla , GUENEAU, Franck , VENET-BONNOT, Sophie
Inventor： FISCHER, Nicolas , KOSCO-VILBOIS, Marie , RAVN, Ulla , GUENEAU, Franck , VENET-BONNOT, Sophie
IPC: C12N15/10
CPC classification number: C12N15/1037 , C07K16/005 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C12N15/66 , C40B40/08 , C40B50/06
Abstract: The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence.
Abstract translation: 本发明提供用于产生编码同源多肽的DNA序列文库的组合物和方法，以及文库用于鉴定天然多样化多肽变体的用途。 本发明还提供用于产生合成抗体片段的组合物的组合物和方法，其中一个或几个互补决定区域（CDR）被从天然来源捕获的相应CDR的集合代替。 本发明还提供了通过插入合成或天然来源的多样化序列多样化多肽的组合物和方法，而不需要修饰原始多肽编码序列。
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