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公开(公告)号：WO2010142461A3
公开(公告)日：2011-11-24
申请号：PCT/EP2010003541
申请日：2010-06-14
Applicant: PAION DEUTSCHLAND GMBH , PETERSEN KARL-UWE , NESHEIM MICHAEL ERNEST , FOLEY JONATHAN HERBERT
Inventor： PETERSEN KARL-UWE , NESHEIM MICHAEL ERNEST , FOLEY JONATHAN HERBERT
IPC: A61K38/36 , A61P7/04 , C07K14/745 , C12Q1/00
CPC classification number: C12Q1/56 , A61K38/366 , C07K14/7455 , C12Q2521/537 , G01N33/86
Abstract: The present invention relates to the use of thrombomodulin analogues for the manufacture of a medicament for the treatment of coagulopathy with hyperfibrinolysis, such as haemophilia disorders. These thrombomodulin analogues exhibit at therapeutically effective dosages an antifibrinolytic effect. Novel protein modifications together with methods for their identification are disclosed.
Abstract translation: 本发明涉及血栓调节素类似物在制备用于治疗具有纤溶亢进的凝血障碍如血友病障碍的药物中的用途。 这些血栓调节蛋白类似物在治疗有效剂量下表现出抗纤维蛋白溶解作用。 公开了新的蛋白质修饰以及它们鉴定的方法。
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公开(公告)号：WO2011157283A1
公开(公告)日：2011-12-22
申请号：PCT/EP2010/007632
申请日：2010-12-15
Applicant: PAION DEUTSCHLAND GMBH , PETERSEN, Karl-Uwe , NESHEIM, Michael Ernest , FOLEY, Jonathan Herbert
Inventor： PETERSEN, Karl-Uwe , NESHEIM, Michael Ernest , FOLEY, Jonathan Herbert
IPC: A61K38/36 , C12Q1/00 , A61P7/04 , C07K14/745
CPC classification number: C07K14/7455
Abstract: The present invention relates to the use of thrombomodulin analogues for the manufacture of a medicament for the treatment of coagulopathy with hyperfibrinolysis, such as haemophilia disorders. These thrombomodulin analogues exhibit at therapeutically effective dosages an antifibrinolytic effect. Novel protein modifications together with methods for their identification are disclosed.
Abstract translation: 本发明涉及血栓调节蛋白类似物在制备用于治疗血纤维蛋白溶解如血友病障碍的凝血病的药物中的用途。 这些血栓调节蛋白类似物以治疗有效剂量表现出抗纤维蛋白溶解作用。 公开了新的蛋白质修饰及其鉴定方法。
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公开(公告)号：WO2010142461A2
公开(公告)日：2010-12-16
申请号：PCT/EP2010/003541
申请日：2010-06-14
Applicant: PAION DEUTSCHLAND GMBH , PETERSEN, Karl-Uwe , NESHEIM, Michael Ernest , FOLEY, Jonathan Herbert
Inventor： PETERSEN, Karl-Uwe , NESHEIM, Michael Ernest , FOLEY, Jonathan Herbert
CPC classification number: C12Q1/56 , A61K38/366 , C07K14/7455 , C12Q2521/537 , G01N33/86
Abstract: The present invention relates to the use of thrombomodulin analogues for the manufacture of a medicament for the treatment of coagulopathy with hyperfibrinolysis, such as haemophilia disorders. These thrombomodulin analogues exhibit at therapeutically effective dosages an antifibrinolytic effect. Novel protein modifications together with methods for their identification are disclosed.
Abstract translation: 本发明涉及血栓调节蛋白类似物在制备用于治疗血纤维蛋白溶解如血友病障碍的凝血病的药物中的用途。 这些血栓调节蛋白类似物以治疗有效剂量表现出抗纤维蛋白溶解作用。 公开了新的蛋白质修饰及其鉴定方法。
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公开(公告)号：WO2010142309A1
公开(公告)日：2010-12-16
申请号：PCT/EP2009/004218
申请日：2009-06-12
Applicant: PAION DEUTSCHLAND GMBH , PETERSEN, Karl-Uwe , NESHEIM, Michael, Ernest , FOLEY, Jonathan, Herbert
CPC classification number: C12Q1/56 , A61K38/366 , C07K14/7455 , C12Q2521/537 , G01N33/86
Abstract: The present invention relates to the use of thrombomodulin analogues for the manufacture of a medicament for the treatment of coagulopathy with hyperfibrinolysis, such as haemophilia disorders. These thrombomodulin analogs exhibit at therapeutically effective dosages an antifibrinolytic effect. Novel protein modifications together with methods for their identification are disclosed.
Abstract translation: 本发明涉及血栓调节蛋白类似物在制备用于治疗血纤维蛋白溶解如血友病障碍的凝血病的药物中的用途。 这些血栓调节蛋白类似物以治疗有效剂量表现出抗纤维蛋白溶解作用。 公开了新的蛋白质修饰及其鉴定方法。
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