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公开(公告)号：WO2015189588A1
公开(公告)日：2015-12-17
申请号：PCT/GB2015/051674
申请日：2015-06-09
Applicant: ILLUMINA CAMBRIDGE LIMITED
Inventor： FRASER, Louise , KOKKO-GONZALES, Paula , SLATTER, Andrew
CPC classification number: C12Q1/6806 , C12N15/1003 , C12P19/34 , C12Q1/6846 , C12Q2521/537 , C12Q2527/125 , C12Q2527/137 , C12Q2535/122 , C12Q2565/518
Abstract: The present invention relates to methods for preparing samples for subsequent nucleic acid (e.g. DNA) amplification, which methods are simpler to perform than existing methods.
Abstract translation: 本发明涉及用于制备后续核酸（例如DNA）扩增的样品的方法，该方法比现有方法更简单。
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公开(公告)号：WO2010142461A2
公开(公告)日：2010-12-16
申请号：PCT/EP2010/003541
申请日：2010-06-14
Applicant: PAION DEUTSCHLAND GMBH , PETERSEN, Karl-Uwe , NESHEIM, Michael Ernest , FOLEY, Jonathan Herbert
Inventor： PETERSEN, Karl-Uwe , NESHEIM, Michael Ernest , FOLEY, Jonathan Herbert
CPC classification number: C12Q1/56 , A61K38/366 , C07K14/7455 , C12Q2521/537 , G01N33/86
Abstract: The present invention relates to the use of thrombomodulin analogues for the manufacture of a medicament for the treatment of coagulopathy with hyperfibrinolysis, such as haemophilia disorders. These thrombomodulin analogues exhibit at therapeutically effective dosages an antifibrinolytic effect. Novel protein modifications together with methods for their identification are disclosed.
Abstract translation: 本发明涉及血栓调节蛋白类似物在制备用于治疗血纤维蛋白溶解如血友病障碍的凝血病的药物中的用途。 这些血栓调节蛋白类似物以治疗有效剂量表现出抗纤维蛋白溶解作用。 公开了新的蛋白质修饰及其鉴定方法。
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公开(公告)号：WO2010142309A1
公开(公告)日：2010-12-16
申请号：PCT/EP2009/004218
申请日：2009-06-12
Applicant: PAION DEUTSCHLAND GMBH , PETERSEN, Karl-Uwe , NESHEIM, Michael, Ernest , FOLEY, Jonathan, Herbert
CPC classification number: C12Q1/56 , A61K38/366 , C07K14/7455 , C12Q2521/537 , G01N33/86
Abstract: The present invention relates to the use of thrombomodulin analogues for the manufacture of a medicament for the treatment of coagulopathy with hyperfibrinolysis, such as haemophilia disorders. These thrombomodulin analogs exhibit at therapeutically effective dosages an antifibrinolytic effect. Novel protein modifications together with methods for their identification are disclosed.
Abstract translation: 本发明涉及血栓调节蛋白类似物在制备用于治疗血纤维蛋白溶解如血友病障碍的凝血病的药物中的用途。 这些血栓调节蛋白类似物以治疗有效剂量表现出抗纤维蛋白溶解作用。 公开了新的蛋白质修饰及其鉴定方法。
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公开(公告)号：WO2008146259A3
公开(公告)日：2009-02-05
申请号：PCT/IB2008052122
申请日：2008-05-30
Applicant: UNIV LAUSANNE , THOME MARGOT , REBEAUD FABIEN , HAILFINGER STEPHAN
Inventor： THOME MARGOT , REBEAUD FABIEN , HAILFINGER STEPHAN
IPC: G01N33/573 , C12Q1/37
CPC classification number: C12Q1/37 , C12Q2521/537 , G01N2500/02
Abstract: The present invention is based on the surprising finding of a proteolytic cleavage function of human Malt1. More particularly, the present invention relates to enzyme and screening assays, methods for assessing cleaving activity, methods for screening, isolated polypeptides, antibodies and inhibitors of Malt1. The present invention also relates to the use of Malt1 as a proteolytic enzyme and the use of compounds comprising a peptide comprising an amino acid sequence according to any one of SEQ ID NO: 1-47 as substrates susceptible for specific proteolytic cleavage.
Abstract translation: 本发明基于人类Malt1的蛋白水解切割功能的惊人发现。 更具体地，本发明涉及酶和筛选测定法，评估切割活性的方法，筛选方法，分离的多肽，抗体和Malt1抑制剂。 本发明还涉及Malt1作为蛋白水解酶的用途，以及包含含有根据SEQ ID NO：1-47中任一项所述的氨基酸序列的肽的化合物作为易于特异性蛋白水解切割的底物的用途。
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公开(公告)号：WO2004046305A8
公开(公告)日：2005-06-30
申请号：PCT/SG0300261
申请日：2003-11-10
Applicant: AGENCY SCIENCE TECH & RES , XU GUOLIN , MAO PEI-LIN , YU YUAN HONG , LAO YUANZHI , ZHANG CHUNYANG , KWAN MENG HUI , SAW LIN KIAT , TING DOR NGI , POLLA DENNIS LEE
Inventor： XU GUOLIN , MAO PEI-LIN , YU YUAN HONG , LAO YUANZHI , ZHANG CHUNYANG , KWAN MENG HUI , SAW LIN KIAT , TING DOR NGI , POLLA DENNIS LEE
CPC classification number: C12N15/1003 , C12Q1/6806 , C12Q2521/537
Abstract: The present invention relates to methods and system for tissue cell and/or nucleic acid molecule isolation. In particular, to a method for isolating nucleic acid molecules from tissue samples comprising: i) treating a tissue sample with at least one enzyme for tissue dissociation; ii) adding a lytic solution; and iii) isolating nucleic acid molecules. The method further comprises a step of applying hydrodynamic shear force to the product of step (i). The methods and/or system according to the invention are adaptable for use with micromechanical and/or automated processes.
Abstract translation: 本发明涉及用于组织细胞和/或核酸分子分离的方法和系统。 具体地，涉及从组织样品分离核酸分子的方法，包括：i）用至少一种酶处理组织样品用于组织解离; ii）加入溶解液; 和iii）分离核酸分子。 该方法还包括向步骤（i）的产物施加流体力学剪切力的步骤。 根据本发明的方法和/或系统适用于微机械和/或自动化过程。
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Patent Agency Ranking6.发明申请A METHOD FOR IDENTIFICATION, ISOLATION AND PRODUCTION OF ANTIGENS TO A SPECIFIC PATHOGEN 审中-公开用于鉴定，分离和产生抗特异性病原体的方法
公开(公告)号：WO02059148A9
公开(公告)日：2002-10-31
申请号：PCT/EP0200546
申请日：2002-01-21
Applicant: CISTEM BIOTECHNOLOGIES GMBH , MEINKE ANDREAS , NAGY ESZTER , AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
Inventor： MEINKE ANDREAS , NAGY ESZTER , VON AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
IPC: G01N33/50 , A61K39/00 , A61K39/39 , A61K39/395 , A61P31/10 , B64C9/02 , C07K14/195 , C07K14/31 , C07K16/12 , C12N15/02 , C12N15/09 , C12N15/10 , C12P21/02 , C12P21/08 , C12Q1/68 , C40B40/02 , G01N33/15 , G01N33/53
CPC classification number: C40B40/02 , A61K39/00 , C07K14/195 , C07K14/31 , C07K16/1271 , C12N15/1037 , C12N15/1041 , C12Q1/6806 , C12Q2527/125 , C12Q2521/537
Abstract: Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps: - providing an antibody preparation from a plasma pool of said given type of animal or from a human plasma pool or individual sera with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - providing at least one expression library of said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - screening said at least one expression library with said antibody preparation, - identifying antigens which bind in said screening to antibodies in said antibody preparation, - screening the identified antigens with individual antibody preparations from individual sera from individuals with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - identifying the hyperimmune serum-reactive antigen portion of said identified antigens and which hyperimmune serum-reactive antigens bind to a relevant portion of said individual antibody preparations from said individual sera and - optionally isolating said hyperimmune serum-reactive antigens and producing said hyperimmune serum-reactive antigens by chemical or recombinant methods.
Abstract translation: 描述了用于鉴定，分离和产生来自特异性病原体，肿瘤，变应原或易于自身免疫的组织或宿主的超免疫血清反应性抗原的方法，所述抗原适用于给定类型动物的疫苗 其特征在于以下步骤： - 提供来自所述给定类型动物的血浆池或来自人血浆池或个体血清的抗体制剂，其具有抗所述特定病原体，肿瘤，变应原或组织或宿主的抗体 易于自身免疫， - 提供至少一种易于自身免疫的所述特异性病原体，肿瘤，变应原或组织或宿主的表达文库， - 用所述抗体制剂筛选所述至少一种表达文库， - 鉴定结合于 对所述抗体制剂中的抗体进行筛选， - 从具有抗体的个体的个体血清中筛选鉴别的抗原 针对所述特异性病原体，肿瘤，变应原或易于自身免疫的组织或宿主， - 鉴定所述鉴定的抗原的超免疫血清反应性抗原部分，以及哪些超免疫血清反应性抗原与所述单个抗体制剂的相关部分结合 所述个体血清和 - 任选地分离所述超免疫血清反应性抗原并通过化学或重组方法产生所述超免疫血清反应性抗原。
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公开(公告)号：WO1992008807A1
公开(公告)日：1992-05-29
申请号：PCT/US1991008492
申请日：1991-11-13
Applicant: HRI RESEARCH, INC.
Inventor： HRI RESEARCH, INC. , LIN, Lily , ISAACS, Stephen, T. , HEARST, John, E.
IPC: C12Q01/68
CPC classification number: C12Q1/703 , C07K16/44 , C12N15/1003 , C12Q1/6806 , C12Q1/6848 , C12Q2531/113 , C12Q2527/125 , C12Q2521/537
Abstract: Methods and compounds for the preparation of nucleic acid samples. Polymerase inhibitors are treated so as to allow for amplification of nucleic acid from biological sources, including whole blood.
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公开(公告)号：WO2017190834A1
公开(公告)日：2017-11-09
申请号：PCT/EP2017/000549
申请日：2017-05-03
Applicant: EUROIMMUN MEDIZINISCHE LABORDIAGNOSTIKA AG
Inventor： ADx NeuroSciences NV , VANMECHELEN, Eugeen , DE VOS, Ann , ENGELBORGHS, Sebastiaan , PETERS, Oliver , SCHIPKE, Carola
IPC: G01N33/68
CPC classification number: G01N33/6896 , C12Q2521/537 , G01N2333/4703 , G01N2333/4709 , G01N2333/96472 , G01N2800/2821 , G01N2800/304 , G01N2800/54 , G01N2800/56
Abstract: The present invention relates to a diagnostically useful carrier comprising a means for capturing Neurogranin, a means for capturing BACE1 and preferably a means for capturing one or more additional biomarkers; a kit comprising the diagnostically useful carrier, optionally further comprising a means for detecting Neurogranin, a means for detecting BACE1 and preferably a means for detecting the one or more additional biomarkers; and a method comprising the steps contacting a sample from a subject with a means for capturing Neurogranin, isolating the means for capturing Neurogranin from the sample and contacting a sample from a subject with a means for capturing BACE1 and isolating the means for capturing BACE1 from the sample. The diagnosis aims to distinguish a neurodegenerative disease, preferably mild Alzheimer's disease, and depression with or without cognitive impairment.
Abstract translation: 本发明涉及诊断上有用的载体，其包含用于捕获神经颗粒素的工具，用于捕获BACE1的工具并且优选用于捕获一种或多种另外的生物标志物的工具; 包含诊断有用载体的试剂盒，任选地进一步包含用于检测神经颗粒素的工具，用于检测BACE1的工具并且优选地用于检测所述一种或多种另外的生物标志物的工具; 以及包括以下步骤的方法：将来自受试者的样品与用于捕获神经颗粒素的工具接触，从样品中分离用于捕获神经颗粒素的工具，并用来自受试者的样品与用于捕获BACE1的工具接触并从用于捕获BACE1的工具 样品。 诊断旨在区分神经退行性疾病，优选轻度阿尔茨海默病和具有或不具有认知障碍的抑郁症。
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公开(公告)号：WO2016145416A3
公开(公告)日：2016-10-13
申请号：PCT/US2016022211
申请日：2016-03-11
Applicant: BROAD INST INC , MASSACHUSETTS INST TECHNOLOGY
Inventor： GORDON DAVID BENJAMIN , NICOL ROBERT , VOIGT CHRISTOPHER , PARK YONGJIN , ROCKWELL GRAHAM N , DWIVEDI RITIKA
CPC classification number: C12N15/1086 , C07K2319/40 , C07K2319/50 , C12N15/1075 , C12Q1/6809 , C12Q1/6897 , C12Q2521/537 , C12Q2563/159 , C12Q2563/179
Abstract: Disclosed are methods and compositions for labeling target molecules or associated target molecule tags with origin-specific nucleic acid barcodes. The identity, quantity, and/or activity of target molecules originating from particular discrete volumes, such as droplets, for example water-in-oil emulsions, can be determined by determining the sequence of the origin-specific nucleic acid barcodes (optionally in combination with additional barcodes, such as one or more additional nucleic acid and/or peptide barcode).
Abstract translation: 公开了用原产地特异性核酸条形码标记靶分子或相关靶分子标签的方法和组合物。 可以通过确定原核特异性核酸条形码序列（任选组合）来确定源于特定离散体积的靶分子（如小滴，例如油包水乳剂）的身份，数量和/或活性 具有另外的条形码，例如一个或多个另外的核酸和/或肽条形码）。
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10.发明申请VERFAHREN ZUM NACHWEIS VON NUKLEINSÄUREN IN PROBEN MIT BIOLOGISCHEM MATERIAL 审中-公开方法对于核酸的带有生物材料样品检测
公开(公告)号：WO2016046168A1
公开(公告)日：2016-03-31
申请号：PCT/EP2015/071662
申请日：2015-09-22
Applicant: GLYCOTOPE GMBH
Inventor： GOLETZ, Steffen , JAHN, Doreen
CPC classification number: C12Q1/6888 , C12N15/101 , C12N15/1017 , C12Q1/6806 , C12Q2521/537 , C12Q2523/32 , C12Q2545/114
Abstract: Die vorliegende Erfindung betrifft ein Nachweisverfahren für Nukleinsäuren in Proben, die biologisches Material enthalten, sowie ein Kit, mit dessen Bestandteilen das Nachweisverfahren durchgeführt werden kann. Beispielsweise ist das Nachweisverfahren geeignet, um in solchen Proben, die biotechnologisch hergestelltes biologisches Material enthalten, Nukleinsäuren von Wirtszellen, die für die Herstellung des Material verwendet wurden, nachzuweisen.
Abstract translation: 本发明涉及的核酸在含有生物材料，以及作为试剂盒的样品的检测方法，该检测方法可以与它的组件来进行。 例如，该检测方法适合于，核酸，宿主细胞，其被用于材料的制备证明其含有生物技术生物材料这样的样品英寸
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