公开(公告)号：WO2010093889A2

公开(公告)日：2010-08-19

申请号：PCT/US2010/024053

申请日：2010-02-12

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  HURREY, Michael ,  ALARGOV, Dimitar ,  JOHNSTON, Steven, C. ,  ROEPER, Stefanie ,  SNOONIAN, John, R. ,  COWANS, Brett, A. ,  VLAHOVA, Petinka ,  EBERLIN, Alexander ,  EDDLESTON, Mark ,  FRAMPTON, Chris

Inventor： HURREY, Michael ,  ALARGOV, Dimitar ,  JOHNSTON, Steven, C. ,  ROEPER, Stefanie ,  SNOONIAN, John, R. ,  COWANS, Brett, A. ,  VLAHOVA, Petinka ,  EBERLIN, Alexander ,  EDDLESTON, Mark ,  FRAMPTON, Chris

IPC: C07D213/82 ,  A61K31/4418

CPC classification number: C07D213/82

Abstract: This invention relates to solid forms of 2-(2, 4-difluorophenyl)-6-(l- (2,6-difluorophenyl)ureido)nicotinamide and pharmaceutical compositions thereof, and methods and uses therewith.

Abstract translation: 本发明涉及2-（2,4-二氟苯基）-6-（1-（2,6-二氟苯基）脲基）烟酰胺的固体形式及其药物组合物，及其方法和用途

公开(公告)号：WO2010093889A3

公开(公告)日：2010-10-28

申请号：PCT/US2010024053

申请日：2010-02-12

Applicant: VERTEX PHARMA ,  HURREY MICHAEL ,  ALARGOV DIMITAR ,  JOHNSTON STEVEN C ,  ROEPER STEFANIE ,  SNOONIAN JOHN R ,  COWANS BRETT A ,  VLAHOVA PETINKA ,  EBERLIN ALEXANDER ,  EDDLESTON MARK ,  FRAMPTON CHRIS

Inventor： HURREY MICHAEL ,  ALARGOV DIMITAR ,  JOHNSTON STEVEN C ,  ROEPER STEFANIE ,  SNOONIAN JOHN R ,  COWANS BRETT A ,  VLAHOVA PETINKA ,  EBERLIN ALEXANDER ,  EDDLESTON MARK ,  FRAMPTON CHRIS

IPC: C07D213/82 ,  A61K31/4418

CPC classification number: C07D213/82

Abstract: This invention relates to solid forms of 2-(2, 4-difluorophenyl)-6-(l- (2,6-difluorophenyl)ureido)nicotinamide and pharmaceutical compositions thereof, and methods and uses therewith.

Abstract translation: 本发明涉及2-（2,4-二氟苯基）-6-（1-（2,6-二氟苯基）脲基）烟酰胺及其药物组合物的固体形式及其方法和用途。